Xianhua Fu

ORCID: 0000-0003-1676-5932
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About
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Research Areas
  • Synthesis and biological activity
  • Gastric Cancer Management and Outcomes
  • Click Chemistry and Applications
  • HER2/EGFR in Cancer Research
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Lung Cancer Treatments and Mutations
  • Cancer Research and Treatments
  • Cancer Mechanisms and Therapy
  • Quinazolinone synthesis and applications
  • Cancer therapeutics and mechanisms
  • Monoclonal and Polyclonal Antibodies Research
  • Cancer, Hypoxia, and Metabolism
  • Employment and Welfare Studies
  • Workplace Health and Well-being
  • Glioma Diagnosis and Treatment
  • Anesthesia and Neurotoxicity Research
  • Cancer Risks and Factors
  • PI3K/AKT/mTOR signaling in cancer
  • Clinical Nutrition and Gastroenterology
  • RNA modifications and cancer
  • Health, psychology, and well-being
  • Lipid metabolism and disorders
  • Nanoplatforms for cancer theranostics
  • Synthesis of heterocyclic compounds
  • Hops Chemistry and Applications

Nanjing Medical University
2013-2025

Hangzhou Medical College
2024

Zhejiang Provincial People's Hospital
2024

Zhejiang University
2011-2024

Xuzhou Medical College
2013-2024

Jiangsu University
2022

Second Affiliated Hospital of Zhejiang University
2018-2021

Chengdu Normal University
2021

Guangzhou Medical University
2011-2015

Shantou University
2015

Tubulin, the major structural component of microtubules, is a target for development anticancer agents. Two series 1,5-diaryl substituted 1,2,3,4-tetrazoles were concisely synthesized, using palladium-catalyzed cross-coupling reaction, and identified as potent antiproliferative agents novel tubulin polymerization inhibitors that act at colchicine site. SAR analysis indicated compounds with 4-ethoxyphenyl group N-1 or C-5 position 1,2,3,4-tetrazole ring exhibited maximal activity. Several...

10.1021/jm2013979 article EN Journal of Medicinal Chemistry 2011-12-02

Traumatic brain injury (TBI) is accompanied by the overload of reactive oxygen species (ROS), which can result in secondary injury. Although procyanidins (PCs) have a powerful free radical scavenging capability and been widely studied treatment TBI, conventional systemic drug therapy cannot make reach targeted area early stage TBI will cause side effects because presence blood–brain barrier (BBB). To address this tissue, we designed fabricated ROS-scavenging functional hydrogel loaded PC...

10.1021/acsami.2c04930 article EN ACS Applied Materials & Interfaces 2022-07-14

In managing severe traumatic brain injury (TBI), emergency surgery involving the removal of damaged tissue and intracerebral hemorrhage is a priority. Secondary caused by oxidative stress energy metabolic disorders, triggered both primary mechanical damage surgical insult, also determining factor in prognosis TBI. Unfortunately, effectiveness traditional postoperative intravenous neuroprotective agents therapy often limited lack targeting, timeliness, side effects when systemically...

10.1016/j.biomaterials.2024.122495 article EN cc-by-nc Biomaterials 2024-01-31

A new series of tubulin polymerization inhibitors based on the 2-aryl/heteroaryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole scaffold was synthesized and evaluated for growth inhibition activity a panel cancer cell lines, cycle effects, in vivo potency. Structure-activity relationships were elucidated with various substitutions at 2-position thiazole skeleton. Hydrophobic moieties, such as phenyl 3-thienyl, well tolerated this position, variation substituents had remarkable effects The...

10.1021/jm300388h article EN Journal of Medicinal Chemistry 2012-05-14

The biological importance of microtubules make them an interesting target for the synthesis antitumor agents. 2-(3',4',5'-trimethoxybenzoyl)-5-aminobenzo[b]thiophene moiety was identified as a novel scaffold preparation potent inhibitors microtubule polymerization acting through colchicine site tubulin. position methoxy group on benzo[b]thiophene important maximal antiproliferative activity. Structure-activity relationship analysis established that best activities were obtained with amino...

10.1021/jm4013938 article EN Journal of Medicinal Chemistry 2013-10-28

Abstract This trial was initiated to evaluate the efficacy and safety of pyrotinib in combination with trastuzumab patients human epidermal growth factor receptor 2 (HER2)‐positive recurrent/metastatic colorectal cancer (CRC). In this single‐arm, open‐label, multicenter, phase HER2‐positive CRC were enrolled received oral 400 mg once a day plus intravenous 8 mg/kg loading dose followed by 6 every 3 weeks. The primary endpoint objective response rate (ORR). Disease control (DCR),...

10.1111/cas.15660 article EN cc-by-nc Cancer Science 2022-11-16

Abstract Background Rural-to-urban female migrant workers have a lower quality of life compared to the general population. Improving these conditions remains highly challenging. This paper reports health-related (HRQoL) in an educational project. Methods In this before-and-after study, community-based health education intervention was developed improve workers’ HRQoL and job satisfaction. A factory selected as location implement trial, using design. The included distribution free access...

10.1186/1477-7525-11-123 article EN cc-by Health and Quality of Life Outcomes 2013-07-23

Normal fibroblasts produce extracellular matrix (ECM) components that form the structural framework of tissues. Cancer-associated (CAFs) with an activated phenotype mainly contribute to ECM deposition and construction cancer masses. However, stroma breast tissues has been shown be more complicated, mechanisms through which CAFs influence remain elusive. In this study, we found fibroblast marker α-smooth muscle actin (α-SMA) was only present in tissue, isolated from invasive sample remained...

10.3892/ijo.2014.2562 article EN International Journal of Oncology 2014-07-25

Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive species (ROS) production and dysregulated antioxidant mechanisms, which fail clear excess ROS. This ROS overload promotes expression of pro-inflammatory genes, releasing cytokines chemokines creating a vicious "ROS-neuroinflammation" cycle, making it essential break this cycle for effective TBI treatment. In study, we developed cysteine-alanine-glutamine-lysine (CAQK) peptide-modified...

10.1186/s12951-025-03251-y article EN cc-by Journal of Nanobiotechnology 2025-03-05

Inonotus obliquus Polysaccharide ( IOP ) is a large molecule extracted from obliqus , medicinal fungus, which has wide range of biological activities and been shown to be associated with inflammation. The purpose this study investigate whether can help reduce acute endometritis by regulating intestinal flora. We observed pathological changes in mice following treatment evaluated the levels interleukin-6 (IL-6), interleukin-1β (IL-1β) tumor necrosis factor α (TNF-α), further studied effects...

10.1371/journal.pone.0259570 article EN cc-by PLoS ONE 2021-11-05

Attention dysfunction has been observed among many kinds of nervous system diseases, including glioma. This study aimed to investigate the correlation between glioma localization, malignancy, postoperative recovery time and attention deficit.A total 45 patients with who underwent surgical resection 18 healthy volunteers were enrolled. The network test, digital span color trail test II Stroop used detect characteristics deficit.Orientation was detected in parietal lobe tumor group, execution...

10.1186/1477-7819-12-317 article EN cc-by World Journal of Surgical Oncology 2014-10-15

e15554 Background: HER2 is an emerging treatment target for colorectal cancer (CRC). Previous phase 2 trials have demonstrated the promising antitumor activity of dual inhibition with trastuzumab plus lapatinib or pertuzumab in HER2-positive metastatic CRC. Pyrotinib, a novel irreversible HER2/EGFR tyrosine kinase inhibitor, has been approved breast 2018 China. The effect pyrotinib was also shown other solid tumors, such as lung and gastric cancer. randomized 3 PHOEBE trial proved that...

10.1200/jco.2021.39.15_suppl.e15554 article EN Journal of Clinical Oncology 2021-05-20

Glioma is the most common type of primary brain tumor, which associated with a poor prognosis due to its aggressive growth behavior and highly invasive nature. Research regarding glioma pathogenesis expected provide novel methods adjuvant therapy for treatment glioma. The use bioinformatics identify candidate genes commonly used understand genetic basis disease. present study mine disease‑related using gene expression profiles (GSE50021) dual‑channel DNA methylation data (GSE50022). results...

10.3892/ol.2017.6579 article EN Oncology Letters 2017-07-15

Resistance has been reported to human epidermal growth factor receptor 2 (HER2)-targeted therapy with the tyrosine kinase inhibitor lapatinib and antibody trastuzumab in metastatic gastric cancer. An alternative or complement might be target extracellular domain of HER2 therapy-effective radionuclides. The fraction patients expression primary tumors major sites, e.g., lymph nodes liver, was analyzed evaluate potential for such therapy. Samples from node liver metastases were taken each...

10.1007/s13277-014-1830-3 article EN Tumor Biology 2014-03-18

Lung cancer has the highest incidence and mortality rates among malignant tumor types worldwide. Platinum‑based chemotherapy is main treatment for advanced non‑small‑cell lung (NSCLC), epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) have greatly improved survival of patients with EGFR‑sensitive mutations. However, there no standard therapy treating who are EGFR‑TKI resistant. Combining EGFR‑TKIs platinum‑based most popular strategy in clinical practice. synergistic...

10.3892/ijo.2020.5103 article EN cc-by-nc-nd International Journal of Oncology 2020-07-27

Knowledge concerning concordance of epidermal growth factor receptor 2 (HER2) expression between primary breast cancers and asynchronous local-regional recurrences is sparse. Receptor characteristics could be altered with time may affected by anticancer treatment. It remains uncertain whether have the identical or similar HER2 pattern as cancer. The aim present study was to evaluate stable during process recurrence. Expression investigated immunohistochemically in paired samples...

10.3892/etm.2011.335 article EN Experimental and Therapeutic Medicine 2011-01-01
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