A5077769217- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Intracerebral and Subarachnoid Hemorrhage Research
- Heme Oxygenase-1 and Carbon Monoxide
- S100 Proteins and Annexins
- Topic Modeling
- Cardiac Arrest and Resuscitation
- Glioma Diagnosis and Treatment
- Fuel Cells and Related Materials
- Machine Learning in Healthcare
- Cancer Research and Treatments
- Thermal Regulation in Medicine
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Advanced battery technologies research
- Advanced Nanomaterials in Catalysis
- Curcumin's Biomedical Applications
- Traumatic Brain Injury Research
- Bone Tissue Engineering Materials
- Respiratory Support and Mechanisms
- Advanced Battery Technologies Research
- Optical Imaging and Spectroscopy Techniques
- Anesthesia and Neurotoxicity Research
- Radiation Therapy and Dosimetry
Shanghai Jiao Tong University
2024-2025
Nanjing Medical University
2023-2025
Shanghai Fire Research Institute
2024
Southern University of Science and Technology
2024
Sunchon National University
2024
China Agricultural University
2023
Xuzhou Medical College
2020-2022
Jiangsu University
2022
Xuzhou University of Technology
2020-2021
Traumatic brain injury (TBI) is accompanied by the overload of reactive oxygen species (ROS), which can result in secondary injury. Although procyanidins (PCs) have a powerful free radical scavenging capability and been widely studied treatment TBI, conventional systemic drug therapy cannot make reach targeted area early stage TBI will cause side effects because presence blood–brain barrier (BBB). To address this tissue, we designed fabricated ROS-scavenging functional hydrogel loaded PC...
Abstract Survival after severe traumatic brain injury (TBI) depends on minimizing or avoiding secondary insults to the brain. Overproduction of reactive oxygen species (ROS) and Ca 2+ influx at damaged site are key factors that cause upon TBI. Herein, a TBI‐targeted lipid covered radical scavenger nanoparticle is developed deliver nimodipine (Np) (CL‐PPS/Np), in order inhibit neurons by Np scavenge ROS trauma microenvironment poly(propylene sulfide) 60 (PPS ) thus prevent TBI‐associated...
In managing severe traumatic brain injury (TBI), emergency surgery involving the removal of damaged tissue and intracerebral hemorrhage is a priority. Secondary caused by oxidative stress energy metabolic disorders, triggered both primary mechanical damage surgical insult, also determining factor in prognosis TBI. Unfortunately, effectiveness traditional postoperative intravenous neuroprotective agents therapy often limited lack targeting, timeliness, side effects when systemically...
Glioma is the most aggressive primary malignant brain tumor.
Glioma is the most prevalent type of malignant brain tumor and usually very aggressive. Because high invasiveness aggressive proliferative growth glioma, it difficult to resect completely or cure with surgery. Residual glioma cells are a primary cause postoperative recurrence. Herein, we describe hypoxia-responsive lipid polymer nanoparticle (LN) for fluorescence-guided surgery, chemotherapy, photodynamic therapy (PDT), photothermal (PTT) combination multitherapy strategies targeting glioma....
Correction for ‘Injectable postoperative enzyme-responsive hydrogels reversing temozolomide resistance and reducing local recurrence after glioma operation’ by Zongren Zhao <italic>et al.</italic>, <italic>Biomater. Sci.</italic>, 2020, <bold>8</bold>, 5306–5316, DOI: 10.1039/D0BM00338G.
Abstract Background Hypothermia is a promising therapy for traumatic brain injury (TBI) in the clinic. However, neuroprotective outcomes of hypothermia-treated TBI patients clinical studies are inconsistent due to several severe side effects. Here, an injectable refrigerated hydrogel was designed deliver 3-iodothyronamine (T1AM) achieve longer period local hypothermia treatment. Hydrogel has four advantages: (1) It can be injected into injured sites after TBI, where it forms and avoids...
Background Cerebral hemorrhage is a critical medical condition that necessitates rapid and precise diagnosis for timely intervention, including emergency operation. Computed tomography (CT) essential identifying cerebral hemorrhage, but its effectiveness limited by the availability of experienced radiologists, especially in resource-constrained regions or when shorthanded during holidays at night. Despite advancements artificial intelligence–driven diagnostic tools, most require technical...
Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive species (ROS) production and dysregulated antioxidant mechanisms, which fail clear excess ROS. This ROS overload promotes expression of pro-inflammatory genes, releasing cytokines chemokines creating a vicious "ROS-neuroinflammation" cycle, making it essential break this cycle for effective TBI treatment. In study, we developed cysteine-alanine-glutamine-lysine (CAQK) peptide-modified...
Radiotherapy (RT) has become one of the most effective treatments for malignant tumor. Intra-tumoral hypoxia is recognized as a chief reason that induces resistance to radiation. Moreover, toxicities RT normal tissues limits usage high doses radiation eliminate cancer cells. Therefore, developing an radiosensitizer critical improving curative effects RT. In present study, we developed angiopep-2 (A2) modified hypoxic lipid (HLR) coated gold nanoparticles (GNPs) (referred A2-HRGNPs) increase...
<title>Abstract</title> In polymer electrolyte membrane fuel cell (PEMFC), the cost and durability are main challenges to commercialization. To achieve long-term target, of PEMFC materials should be further improved. this paper, we investigated chemical electrochemical degradation expanded polytetrafluoroethylene (e-PTFE) support examined how it influences mechanical properties e-PTFE support. We conducted Fenton test open circuit voltage (OCV) holding analyzed physical structural changes by...
<sec> <title>BACKGROUND</title> Cerebral hemorrhage is a critical medical condition which necessitates rapid and precise diagnosis for timely intervention including emergency operation. Computed Tomography (CT) essential identifying cerebral hemorrhage, while its effectiveness limited by the availability of experienced radiologists, especially in resource-constrained regions or when shorthanded during holidays night. Despite advancements artificial intelligence (AI)-driven diagnostic tools,...
Abstract Hypothermia is a promising therapy for Traumatic brain injury (TBI) in the clinic. However, neuroprotective outcomes of hypothermia-treated TBI are not consistent clinical studies due to several severe side effects. Here, an injectable refrigerated hydrogel designed deliver 3-iodothyronamine (T1AM) achieve longer period local hypothermia treatment. The has four advantages: (1) It can be injected into injured site after TBI, where it forms and avoids effects whole-body cooling. (2)...
The pathogenesis of delayed cerebral edema after intracerebral hemorrhage is still unclear. In this case report, we speculate that the formation subdural effusion or associated with edema. By referring to treatment plan chronic hematoma, adding dexamethasone routine medication, certain therapeutic effect has been achieved. Dexamethasone may maintain stability blood-brain barrier by directly increasing expression ZO-1, and reduce neuroinflammatory response caused NF-κB pathway upregulating...
Targeted Drug Delivery As shown in the cover picture, after brain injury, two groups of engineers (representing Np and PPS) are quickly sent to injury area under targeted transportation a vehicle (CL-PPS/Np), effectively prevent by blocking Ca2+ influx decreasing ROS level through combination properties PPS. This work is found article number 2102256 Shanshan Li, Rutong Yu, Hongmei Liu, co-workers.