A5066672079- Infant Nutrition and Health
- Gut microbiota and health
- Digestive system and related health
- Viral gastroenteritis research and epidemiology
- Probiotics and Fermented Foods
- Growth Hormone and Insulin-like Growth Factors
- Clinical Nutrition and Gastroenterology
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Animal Behavior and Welfare Studies
- Birth, Development, and Health
- Animal Nutrition and Physiology
- Animal Genetics and Reproduction
- Bone and Dental Protein Studies
- Clostridium difficile and Clostridium perfringens research
- Infant Health and Development
- Immune Cell Function and Interaction
- Child Nutrition and Water Access
- Immune Response and Inflammation
- Nutrition, Genetics, and Disease
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Neonatal and Maternal Infections
- Regulation of Appetite and Obesity
- Effects and risks of endocrine disrupting chemicals
University of Illinois Urbana-Champaign
2015-2024
Urbana University
2009-2021
University of Illinois System
2015
Goodwin College
2013
Food and Nutrition Service
2011
University of California, Davis
1999
Human milk (HM) is rich in oligosaccharides (HMO) that exert prebiotic and anti-infective activities. HM feeding reduces the incidence of rotavirus (RV) infection infants. Herein, anti-RV activity was tested an established vitro system for assessing cellular binding viral infectivity/replication, also a newly developed, acute RV infection, situ piglet model. For work, crude HMO isolated from pooled HM, neutral (lacto- N -neotetraose, LNnT; 2′-fucosyllactose) acidic (aHMO, 3′-sialyllactose,...
Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than developing countries. We compared nutritional status, immune response microbiota composition mestizo children with ASD matched controls Ecuador. Twenty-five cases 35 were by age, sex school location. The prevalence of under- overweight was higher ASD. Nutritional differences accompanied abnormal food habits more frequent gastrointestinal...
This study tested the hypothesis that addition of prebiotics and 2 functional milk ingredients to infant formula would maintain normal growth gut development, modify microbiota composition neurotransmitter gene expression in neonatal piglets.Two-day-old male piglets (n = 24) were fed (CONT) or with polydextrose (1.2 g/100 g diet), galactooligosaccharides (3.5 bovine lactoferrin (0.3 fat globule membrane-10 (2.5 diet) (TEST) for 30 days. On day 31, intestinal samples, ileal colonic contents,...
We have developed a novel molecular methodology that utilizes stool samples containing intact sloughed epithelial cells to quantify intestinal gene expression profiles in the developing human neonate. Since nutrition exerts major role regulating neonatal development and function, our goal was identify sets (combinations) are differentially regulated response infant feeding. For this purpose, fecal mRNA isolated from exclusively breast-fed (n = 12) formula-fed 10) infants at 3 mo of age....
Abstract This study investigates the relationship between serum hormone levels and morphometrics during ontogeny in olive baboons ( Papio hamadryas anubis ) sooty mangabeys Cercocebus atys ), to test hypotheses about endocrine regulation of species size differences. First, we expect that hormones binding proteins predict change both species. Second, a high level integration among analyzed is expected, with implication they act combination influence development body shape. Utilizing mixed...
Milk oligosaccharides (OS) shape microbiome structure and function, but their relative abundances differ between species. Herein, the impact of human milk (HMO) (2′-fucosyllactose [2′FL] lacto-N-neotetraose [LNnT]) OS isolated from bovine (BMOS) on microbiota composition volatile fatty acid (VFA) concentrations in ascending colon (AC) contents feces was assessed. Intact male piglets received diets either containing 6.5 g/L BMOS (n = 12), 1.0 2′FL + 0.5 LNnT (HMO; n both (HMO BMOS; 10), or...
Sialyllactose (SL) is a highly abundant oligosaccharide in human milk that has been shown to influence intestinal maturation and cognitive development exert bifidogenic effects on the gut microbiota. The SL content of infant formula significantly less than milk, therefore there interest determining effect supplementing at levels neonatal outcomes. aim this study was investigate varying doses dietary compared with replacer weight gain, gastrointestinal development, microbiota composition...
Young male rats subjected to a dietary manganese (Mn) deficiency respond the by reducing their growth rate. The hormone (GH)/insulin-like factor (IGF) axis is critical for linear growth; this system exquisitely sensitive nutritional state of animal. In study, we examined circulating GH, IGF-1, and insulin levels in Mn-deficient (-Mn; fed 0.5 μg Mn/g diet) sufficient (+Mn; 45 Sprague-Dawley rats. Additionally, distribution IGF binding proteins (IGFBPs) animals both groups as these modulate...
Sialyllactose (SL) is an abundant oligosaccharide in human milk with health benefits that include intestinal maturation, gut microbiota modulation, and cognitive development. Recent technological advances support large scale production of different forms sialyllactose, which will enable their use as a food ingredient. The objective the study was to investigate dose-dependent effects novel enzymatically-synthesized 3'-sialyllactose (3'SL) sodium salt supplemented swine replacer on growth,...
ABSTRACT Infants are susceptible to infections in early life and must rely on their innate immune system for protection. β-Glucans potentiate responses. Therefore, we evaluated the influence of purified yeast (1,3/1,6)-β- d -glucan (Wellmune WGP, here referred as WGP) development gastrointestinal tract intestinal systemic systems neonatal piglets. Piglets were fed formula containing 0 (control), 1.8, 18, or 90 mg WGP/kg body weight (BW) vaccinated against human influenza. euthanized at 7 21...
The aim of the study was to determine effect polydextrose (PDX) and galactooligosaccharide (GOS) on bacterial translocation (BT) in neonatal piglets.Piglets (n = 36) were randomized 12 hours after birth receive total enteral nutrition (TEN) as formula; TEN + GOS (4 g/L), PDX or (2 g/L each) for 7 days supported by parenteral (TPN) a positive control BT 8). Blood, spleen, liver, mesenteric lymph node (MLN) samples cultured aerobic anaerobic bacteria. Colon microbiota 16S rDNA measured...
Oligosaccharides are complex, non-digestible glycans found in large abundance human milk. The and the profile of bovine milk oligosaccharides based infant formula differ from those Recently, some (HMOs) have been supplemented to formula, however, not all forms available scale. objective study was investigate dose-dependent effects an enzymatically-synthesized 6′-sialyllactose (6′-SL) sodium salt swine replacer on growth, hematological parameters, organ microscopic assessment our pre-clinical...
Human milk is rich in oligosaccharides that influence intestinal development and serve as prebiotics for the infant gut microbiota. Probiotics 2'-fucosyllactose (2'-FL) added individually to formula have been shown development, but less known about effects of their synbiotic administration. Herein, impact supplementation with Bifidobacterium longum subsp. infantis Bi-26 (Bi-26), or 2'-FL + on weight gain, organ weights, piglets was investigated. Two-day-old (n = 53) were randomized a 2 ×...
The objectives of this study were to use transgenic sows that overexpress IGF-I in milk investigate the effect a short-term fast on piglet intestinal morphology and disaccharidase activity determine how milk-borne influences response fasting. After farrowing, litters normalized 10 piglets. On d 6, piglets (n = 30) suckling (TG) nontransgenic (control) assigned randomly three treatments: fed (0 h), which remained with sow until euthanized 7, or fasted piglets, removed from at either 6 12 h...