A5081797553- Herpesvirus Infections and Treatments
- Drilling and Well Engineering
- Oil and Gas Production Techniques
- Animal Virus Infections Studies
- Polymer crystallization and properties
- Bone Tissue Engineering Materials
- Cytomegalovirus and herpesvirus research
- Electrospun Nanofibers in Biomedical Applications
- Hydraulic Fracturing and Reservoir Analysis
- Polymer Science and PVC
- Astronomy and Astrophysical Research
- biodegradable polymer synthesis and properties
- Offshore Engineering and Technologies
- Stellar, planetary, and galactic studies
- Hydrogen embrittlement and corrosion behaviors in metals
- Hydrogels: synthesis, properties, applications
- Dermatology and Skin Diseases
- Graphene and Nanomaterials Applications
- Microstructure and Mechanical Properties of Steels
- Wound Healing and Treatments
- Engineering Structural Analysis Methods
- Neuropeptides and Animal Physiology
- Toxin Mechanisms and Immunotoxins
- Nerve injury and regeneration
- Pressure Ulcer Prevention and Management
University of Cincinnati
2023-2025
South College
2017-2024
Massachusetts Institute of Technology
1985-2022
Vanderbilt University
2014-2022
GlaxoSmithKline (United States)
2017
Indiana University School of Medicine
2013
Indiana University – Purdue University Indianapolis
2013
Pacific Environment
2003
Victoria University of Wellington
1997-2000
California Polytechnic State University
1999
Abstract This work reviews the literature published over last ten years on polymer mechanical properties as a function of molecular weight and distribution, Thermal properties, stress‐strain impact, fracture, fatigue, creep, stress relaxation cracking crazing are examined for wide variety homopolymers limited number copolymers. In general, increase increases. However, above some limiting property is usually unaffected. Although much has been done to describe effects little quantitative...
A combination of anionic and RAFT polymerization was used to synthesize an ABC triblock polymer poly[(propylenesulfide)-block-(N,N-dimethylacrylamide)-block-(N-isopropylacrylamide)] (PPS-b-PDMA-b-PNIPAAM) that forms physically cross-linked hydrogels when transitioned from ambient physiologic temperature incorporates mechanisms for reactive oxygen species (ROS) triggered degradation drug release. At (25 °C), PPS-b-PDMA-b-PNIPAAM assembled into 66 ± 32 nm micelles comprising a hydrophobic PPS...
Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds. Synthetic are less expensive to manufacture than biologic dressings achieve a broader range physiochemical properties, but opportunities remain tailor these materials for ideal host immune regenerative responses. Polyesters well-established class synthetic biomaterials; however, acidic degradation products released by their hydrolysis...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComprehensive Approach toward Understanding Element Speciation and Leaching Behavior in Municipal Solid Waste Incineration Electrostatic Precipitator AshT. Taylor. Eighmy, J. Dykstra. Eusden, James E. Krzanowski, David S. Domingo, Dominique. Staempfli, John R. Martin, Patricia M. EricksonCite this: Environ. Sci. Technol. 1995, 29, 3, 629–646Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March...
Abstract The molecular weight and distribution of a polymer can markedly affect its mechanical properties. While this has been recognized for long time, quantitative studies have relatively difficult to perform number reasons. A major problem the characterization complete curve by fractionation methods because fraction collection determination various averages polymers is time consuming. Additionally, measurement number-average weight, [Mbar]n, classical osmometry procedure often unreliable.
The utility of layer-by-layer (LbL) coated microneedle (MN) skin patches for transdermal drug delivery has proven to be a promising approach, with advantages over hypodermal injection due painless and easy self-administration. However, the long epidermal application time required implantation by existing LbL MN strategies (15-90 min) can lead potential medication noncompliance. Here, we developed platform shorten in therapies based on synthetic pH-induced charge-invertible polymer...
Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) implanted wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing progrowth genes and vasculature, proliferating cells, development wounds.
Abstract The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery new medicines. We have developed novel method that rapidly screens multiple proteins parallel using DNA-encoded library technology (ELT). Initial efforts were focused on efficient antibacterial leads against 119 from Acinetobacter baumannii Staphylococcus aureus . success this effort led to hypothesis relative number ELT binders alone could be used assess...
Abstract Polycarbonate tensile bars were aged up to 18 months at 0%, 75%, and 100% relative humidity temperatures of 65–93°C. In the humid samples hydrolysis caused progressive reductions in molecular weight. Below a critical weight ( M w = 33,800, n 14,300) strength dropped off rapidly. A transition from ductile brittle failure was also observed that point. Extrapolations indicate ductile–brittle 38°C will be reached after 5 years for polycarbonate studied. Elongation affected even early...
Abstract Clinical application of injectable, thermoresponsive hydrogels is hindered by lack degradability and controlled drug release. To overcome these challenges, a family thermoresponsive, ABC triblock polymer‐based has been engineered to degrade release cargo through either oxidative or hydrolytic/enzymatic mechanisms dictated the “A” block composition. Three copolymers are synthesized with varying blocks, including oxidation‐sensitive poly(propylene sulfide), slow...
Cell therapies suffer from poor survival post-transplant due to placement into hostile implant sites characterized by host immune response and innate production of high levels reactive oxygen species (ROS). We hypothesized that cellular encapsulation within an injectable, antioxidant hydrogel would improve viability cells exposed oxidative stress. To test this hypothesis, we applied a dual thermo- ROS-responsive comprising the ABC triblock polymer poly[(propylene sulfide)-block-(N,N-dimethyl...
Abstract A 77‐year‐old man with T‐cell lymphoma developed an acute fatal meningoradiculitis of cranial nerve roots and cauda equina, pathologically virologically confirmed to be caused by varicella‐zoster virus. This is the first report virus‐induced neurological disease in absence skin lesions. Varicellazoster virus should included differential diagnosis radiculoneuropathy immunocompromised patient, particularly because antiviral treatment for exists.
Abstract Polyelectrolyte multilayer (PEM) coatings, constructed on the surfaces of tissue engineering scaffolds using layer‐by‐layer assembly (LbL), promote sustained release therapeutic molecules and have enabled regeneration large‐scale, pre‐clinical bone defects. However, these systems primarily rely non‐specific hydrolysis PEM components to foster drug release, their pre‐determined delivery schedules potentially limit future translation into innately heterogeneous patient populations. To...
Traditionally used bone substitutes do not yield desired regeneration outcomes in critically-sized defects. Oxidation sensitive are an alternative that produce improved large-scale