A5075476806- Electrospun Nanofibers in Biomedical Applications
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- Congenital Anomalies and Fetal Surgery
- Parasitic infections in humans and animals
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- Photopolymerization techniques and applications
- Mesenchymal stem cell research
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Urological Disorders and Treatments
- Renal and Vascular Pathologies
- Hepatitis Viruses Studies and Epidemiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Forest ecology and management
- Vaccine Coverage and Hesitancy
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Obesity, Physical Activity, Diet
- Polymer composites and self-healing
Vanderbilt University
2015-2025
Bombay Hospital
2024
B.P. Koirala Institute of Health Sciences
2012-2023
Vivekananda Global University
2022
Gyan Vihar University
2022
Bundelkhand University
2021
National Institute of Technology Rourkela
2020-2021
Post Graduate Institute of Medical Education and Research
2007-2020
Christie's
2020
Indian Institute of Technology BHU
2020
A family of pH-responsive diblock polymers composed poly[(ethylene glycol)-b-[(2-(dimethylamino)ethyl methacrylate)-co-(butyl methacrylate)], PEG-(DMAEMA-co-BMA), was reversible addition-fragmentation chain transfer (RAFT) synthesized with 0-75 mol % BMA in the second polymer block. The relative mole DMAEMA and varied order to identify a that can be used formulate PEGylated, siRNA-loaded polyplex nanoparticles (NPs) an optimized balance cationic hydrophobic content NP core based on siRNA...
A combination of anionic and RAFT polymerization was used to synthesize an ABC triblock polymer poly[(propylenesulfide)-block-(N,N-dimethylacrylamide)-block-(N-isopropylacrylamide)] (PPS-b-PDMA-b-PNIPAAM) that forms physically cross-linked hydrogels when transitioned from ambient physiologic temperature incorporates mechanisms for reactive oxygen species (ROS) triggered degradation drug release. At (25 °C), PPS-b-PDMA-b-PNIPAAM assembled into 66 ± 32 nm micelles comprising a hydrophobic PPS...
Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds. Synthetic are less expensive to manufacture than biologic dressings achieve a broader range physiochemical properties, but opportunities remain tailor these materials for ideal host immune regenerative responses. Polyesters well-established class synthetic biomaterials; however, acidic degradation products released by their hydrolysis...
A system is engineered for temporally controlled delivery of siRNA from biodegradable tissue regenerative scaffolds. Therapeutic application this approach to silence PHD2 promotes expression pro-angiogenic genes by HIF1α and enhanced scaffold vascularization in vivo. This technology provides a new standard efficient controllable gene silencing modulate host response within biomaterials. As service our authors readers, journal supporting information supplied the authors. Such materials are...
Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) implanted wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing progrowth genes and vasculature, proliferating cells, development wounds.
Background. Japanese encephalitis (JE) is a vaccine-preventable acute disease. We report the results of phase 2/3 trial JENVAC, Vero cell–derived vaccine developed using an Indian strain JE virus (JEV).
Breast cancer patients are at high risk for bone metastasis. Metastatic disease is a major clinical problem that leads to reduction in mobility, increased of pathologic fracture, severe pain, and other skeletal-related events. The transcription factor Gli2 drives expression parathyroid hormone-related protein (PTHrP), which activates osteoclast-mediated destruction, previous studies showed genetic repression bone-metastatic tumor cells significantly reduces tumor-induced destruction. Small...
Post-traumatic osteoarthritis (PTOA) associated with joint injury triggers a degenerative cycle of matrix destruction and inflammatory signaling, leading to pain loss function. Here, prolonged RNA interference (RNAi) metalloproteinase 13 (MMP13) is tested as PTOA disease modifying therapy. MMP13 upregulated in degrades the key cartilage structural protein type II collagen. Short interfering (siRNA) loaded nanoparticles (siNPs) were encapsulated shape-defined poly(lactic-
Abstract Nanoparticle (NP) supra‐assembly offers unique opportunities to tune macroscopic hydrogels’ mechanical strength, material degradation, and drug delivery properties. Here, synthetic, reactive oxygen species (ROS)‐responsive NPs are physically cross‐linked with hyaluronic acid (HA) through guest‐host chemistry create shear‐thinning NP/HA hydrogels. A library of triblock copolymers composed poly(propylene sulfide)‐ b ‐poly(N, N ‐dimethylacrylamide)‐ ‐dimethylacrylamide‐ co...
Although angiotensin converting enzyme (ACE) inhibitors have been reported to increase coronary blood flow, the effect of selective II (AT1)-receptor antagonism on circulation has not defined.We examined effects AT1-receptor antagonist Losartan (DuP 753, 0.2-3.2 mg/kg) arteries in vivo 11 dogs, using a combination intravascular two-dimensional and Doppler ultrasound. In six 30-MHz, 4.3F ultrasound imaging catheter was placed midsegment circumflex artery measure cross-sectional area (CSA),...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid-vapor equilibriums for the N2 + CH4 C2H6 system from 260 to 280 KMukesh K. Gupta, Glenn C. Gardner, Michael J. Hegarty, and Arthur KidnayCite this: Chem. Eng. Data 1980, 25, 4, 313–318Publication Date (Print):October 1, 1980Publication History Published online1 May 2002Published inissue 1 October 1980https://pubs.acs.org/doi/10.1021/je60087a016https://doi.org/10.1021/je60087a016research-articleACS PublicationsRequest reuse permissionsArticle...
A dual-targeted siRNA nanocarrier has been synthesized and validated that is selectively activated in environments where there colocalization of two breast cancer hallmarks, elevated matrix metalloproteinase (MMP) activity folate receptor overexpression. This self-assembled from polymers containing the same pH-responsive, endosomolytic core-forming block but varying hydrophilic, corona-forming blocks. The corona one polymer consists a 2 kDa PEG attached to terminal folic acid (FA); second...
Abstract Clinical application of injectable, thermoresponsive hydrogels is hindered by lack degradability and controlled drug release. To overcome these challenges, a family thermoresponsive, ABC triblock polymer‐based has been engineered to degrade release cargo through either oxidative or hydrolytic/enzymatic mechanisms dictated the “A” block composition. Three copolymers are synthesized with varying blocks, including oxidation‐sensitive poly(propylene sulfide), slow...
When carboxylated poly(ε-caprolactone) (PCL) is crosslinked with ROS-degradable peptide KP<sub>7</sub>K oligomers and fabricated into porous scaffolds for tissue engineering applications, the exhibit excellent physiological ROS-mediated degradation induction of new blood vessel growth from host.
The inherent antioxidant function of poly(propylene sulfide) (PPS) microspheres (MS) was dissected for different reactive oxygen species (ROS), and therapeutic benefits PPS-MS were explored in models diabetic peripheral arterial disease (PAD) mechanically induced post-traumatic osteoarthritis (PTOA). (∼1 μm diameter) significantly scavenged hydrogen peroxide (H2O2), hypochlorite, peroxynitrite but not superoxide vitro cell-free cell-based assays. Elevated ROS levels (specifically H2O2)...
Myocardial infarction results in extensive cardiomyocyte death which can lead to fatal arrhythmias or congestive heart failure. Delivery of stem cells repopulate damaged cardiac tissue may be an attractive and innovative solution for repairing the heart. Instructive polymer scaffolds with a wide range properties have been used extensively direct differentiation cells. In this study, we optimized chemical mechanical electrospun mesh directed embryonic (ESCs) towards cardiomyogenic lineage. A...
Cell therapies suffer from poor survival post-transplant due to placement into hostile implant sites characterized by host immune response and innate production of high levels reactive oxygen species (ROS). We hypothesized that cellular encapsulation within an injectable, antioxidant hydrogel would improve viability cells exposed oxidative stress. To test this hypothesis, we applied a dual thermo- ROS-responsive comprising the ABC triblock polymer poly[(propylene sulfide)-block-(N,N-dimethyl...