A5006495466- Textile materials and evaluations
- Dendrimers and Hyperbranched Polymers
- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Dyeing and Modifying Textile Fibers
- Nanoplatforms for cancer theranostics
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Industrial Vision Systems and Defect Detection
- Carbon dioxide utilization in catalysis
- Advanced biosensing and bioanalysis techniques
- Wound Healing and Treatments
- Hydrogels: synthesis, properties, applications
- Advanced Nanomaterials in Catalysis
- Skin Protection and Aging
- CRISPR and Genetic Engineering
- Radiopharmaceutical Chemistry and Applications
- Surface Modification and Superhydrophobicity
- Bone health and treatments
- Polymer composites and self-healing
- Pressure Ulcer Prevention and Management
- Free Radicals and Antioxidants
Vanderbilt University
2020-2024
Arizona State University
2024
Italian Institute of Technology
2017-2023
University of Manchester
2013-2023
Nashville Oncology Associates
2021
Commonwealth Scientific and Industrial Research Organisation
1965-1988
Woolmark (Australia)
1965-1966
Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds. Synthetic are less expensive to manufacture than biologic dressings achieve a broader range physiochemical properties, but opportunities remain tailor these materials for ideal host immune regenerative responses. Polyesters well-established class synthetic biomaterials; however, acidic degradation products released by their hydrolysis...
A theoretical isotherm to predict sorption from the vapour phase for heterogeneous sorbents has been derived thermodynamic considerations. The predicted isotherms is a composite curve comprised of component arising three separate processes : (a) monolayer adsorption by strongly binding sites, (b) weakly and (c) formation multilayer extent which limited properties substrate. Components have form Langmuir at surfaces while describing yields modified Langmuir-type equation. In general, can be...
Sustainable biocomposites have been developed by solvent mixing of poly(lactic acid) (PLA) with a fine powder cocoa bean shells (CBS) and subsequent solution casting, using different concentrations CBS. The inclusion CBS recovers the crystallinity initially amorphous PLA films improves physical properties composites. Young's modulus increases 80% 75 wt % inclusion; however, composites maintain plasticity. barrier hydrophobic were characterized, water vapor permeability is found to be ca. 3.5...
Abstract Ischemic stroke is a leading cause of death and long‐term disability worldwide, yet availability current treatments limited. The downstream events resulting from cerebral ischemia lead to an imbalance in the production harmful reactive oxygen species (ROS) over endogenous antioxidant mechanisms. Thus, that can reduce this limit extent injury ischemic stroke. In work, potential novel ROS‐scavenging PEGylated polymeric nanoparticles (NPs) composed poly(propylene sulfide) (PPS)...
Breast cancer patients are at high risk for bone metastasis. Metastatic disease is a major clinical problem that leads to reduction in mobility, increased of pathologic fracture, severe pain, and other skeletal-related events. The transcription factor Gli2 drives expression parathyroid hormone-related protein (PTHrP), which activates osteoclast-mediated destruction, previous studies showed genetic repression bone-metastatic tumor cells significantly reduces tumor-induced destruction. Small...
The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo therapeutic gene editing. Here, we demonstrate that proteins, regardless size or charge, efficiently load into porous silicon nanoparticles (PSiNPs). Optimizing the loading strategy yields formulations are ultrahigh loading─>40% cargo by volume─and highly active. Further tuning polymeric coating on loaded PSiNPs nanocomposites achieve colloidal stability under cryopreservation, endosome escape, and...
REDOX responsive (nano)materials typically exhibit chemical changes in response to the presence and concentration of oxidants/reductants. Due complexity biological environments, it is critical ascertain whether may depend on details stimulus, addition its potential, chemically different responses can determine a overall performance material. Here, we have used oxidation-sensitive materials, although these considerations be extended also reducible ones. In particular, poly(propylene sulfide)...
This study addresses well-known shortcomings of poly(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common method employed to overcome immunogenicity and suboptimal pharmacokinetics of, for example, therapeutic proteins but has significant drawbacks. First, PEG offers no protection from denaturation during lyophilization, storage, or oxidation (e.g., biological oxidants, reactive oxygen species); second, PEG's inherent immunogenicity, leading hypersensitivity...
Experiments are described in which wool–water-vapour adsorption isotherms were determined gravimetrically the temperature range 20–100°C by using a quartz helical spring mounted an evacuable apparatus. Major factors affecting measured water content of wool samples identified as previous history sample, amount vapour pressure is changed, and time allowed for equilibrium to be established; influence these becomes more marked at higher temperatures. Careful control variables study reported this...
We present the evaluation of a sulfoxide-based polymer (poly(propylene sulfoxide), PPSO) as potential 'stealth' macromolecule, and at same time pharmacologically active (anti-inflammatory/anti-oxidant) material. The combination these two concepts may first seem peculiar since gold standard in biomaterials drug delivery, poly(ethylene glycol) (PEG), is due to its chemical biological inertness, which makes it hardly biologically active. Polysulfoxides, on contrary, couple substantial inertness...
This study focuses on the comparative evaluation of star (branched) and linear poly(l,d-lactic acid) (PDLLA) as degradable materials employed in controlled release. The polymers were prepared via ring-opening polymerization initiated by decanol (linear), pentaerythritol (4-armed star) dipentaerythritol (6-armed star), processed both form films nanoparticles. Independent length or number their arms, degrade slower than polymers, possibly through a surface (vs bulk) mechanism. Further, release...
Inflammatory pathologies are a growing burden for developed societies, and the tools offered by medicinal chemistry/biotechnology have provided us with an armamentarium of active principles. Unfortunately, most them marred very significant side effects that can be summarized two words: poor targeting (of cells, tissues, etc.). This review provides broad overview approaches materials used to obtain inflammation‐responsive or inflammation‐targeted behavior, which improve anti‐inflammatory...
We show the first example of a synergic approach oxidant (ROS) scavenging carrier and ROS-responsive drug release in context potential therapy against osteoporosis, aiming to inhibit differentiation inflammatory cells into osteoclasts. In our "tandem" approach, branched amphiphilic, PEGylated polysulfide (PPSES-PEG) was preferred over linear analogue, because improved homogeneity aggregates (spherical micelles vs mixture wormlike spherical), increased stability, higher loading (up ∼22 wt %...
Using polymers with a double stimulus responsiveness, we show that primary structure, in addition to chemical composition, can significantly influence the response. This, however, applies of supramolecular nature (temperature) and not molecular one (oxidation). In anionic ring-opening copolymerization ethylene sulfide (ES) propylene (PS), ES polymerizes faster yields polysulfide chains gradient composition; this structure be varied by modifying mode monomer addition. Polysulfides different...
Families of amphiphilic oxidation-responsive polymers (poly(ethylene glycol)-polysulfides) with different architectures (linear, 4, 6, and 8-armed stars 10, 15, 20-armed combs) compositions (variable ethylene sulfide/propylene sulfide ratio) are prepared. In water, all the assemble in spherical micelles, critical micellar concentrations <0.01 mg mL-1 for branched polymers. Triple-detection gel permeation chromatography (GPC) asymmetric field flow fractionation (AFFF) dynamic static light...
This study is about multiple responsiveness in biomedical materials. typically implies "orthogonality" (i.e., one response does not affect the other) or synergy increases efficacy selectivity of other), but an antagonist effect between responses may also occur. Here, we describe a family very well-defined amphiphilic and micelle-forming block copolymers, which show both oxidative temperature responses. They are produced via successive anionic ring-opening polymerization episulfides RAFT...
We have investigated how variations in primary structure (distribution of monomeric units, chain length) and degree branching affect the crystallization behavior polysulfides. In particular, we used copolymers crystallizable (ethylene sulfide, ES) non-crystallizable (propylene PS) prepared via anionic ring-opening mechanism. PS units interrupt ES sequences; therefore, strong differences thermal properties are expected between with a gradient (single addition ES/PS mixtures) or semirandom...
The Mitsunobu reaction can be efficiently used for the transformation of poly(ethylene glycol) (PEG) terminal OH group(s) into a variety functions. In comparison to more classical approaches PEG functionalization, main advantage attains fact that in one step, with no detrimental effect on integrity (e.g., chain cleavage). Here, its quantitative conversion is demonstrated derivatives that, either directly or after deprotection, are amenable (bio)conjugation reactions: azides (Huisgen...