Ogochukwu Ume

ORCID: 0000-0003-1685-9947
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About
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Research Areas
  • Phytochemistry and Biological Activities
  • Helicobacter pylori-related gastroenterology studies
  • Biological Activity of Diterpenoids and Biflavonoids
  • Toxin Mechanisms and Immunotoxins
  • Ziziphus Jujuba Studies and Applications
  • Advances in Cucurbitaceae Research
  • Natural Compound Pharmacology Studies
  • Venomous Animal Envenomation and Studies
  • Cholesterol and Lipid Metabolism
  • Drug Transport and Resistance Mechanisms
  • Biochemical Analysis and Sensing Techniques
  • Agriculture and Biological Studies
  • Natural Antidiabetic Agents Studies
  • Ginger and Zingiberaceae research
  • Phytochemicals and Antioxidant Activities
  • Essential Oils and Antimicrobial Activity
  • Viral Infections and Vectors
  • Nuts composition and effects
  • Phytochemistry and biological activity of medicinal plants
  • Natural product bioactivities and synthesis
  • Diverse Scientific Research Studies

Igbinedion University
2021-2024

Cassia siamea (SB) is a common medicinal plant in Southwestern Nigeria, known for its usage the management of cancer among locals. The study aimed to unveil claimed anticancer property SB using cytotoxic bench-top bioassays. Cytotoxicity potential was investigated Raniceps raninus and Saccharomyces cerevisiae bioassay models, radical scavenging strength against DPPH stable also unfolded. fractionation resulted three bulked column fractions (SB1 – 3). SB1 observed induce severe DNA damage...

10.26538/tjnpr/v8i1.50 article EN cc-by-nc-nd Tropical Journal of Natural Product Research 2024-02-01

Waltheria indica has been claimed to be used in managing several diseases traditional medicine, although substantial scientific data are not available as regards its safety despite pronounced efficacy management of some ailments. Therefore, methanol leaf extract W. was evaluated for effects on toxicological parameters using experimental animals. However, acute and sub-acute toxicity were carried out animals described by standard methods. Absence death reported after 24 hours single oral...

10.30574/gscbps.2021.17.2.0267 article EN GSC Biological and Pharmaceutical Sciences 2021-11-09

Hymenocardia acida (HA) is one of the numerous medicinal plants in Nigeria with ethnomedicinal history usage treatment ulcer. The study aimed at isolating antiulcer principle(s) from stem bark HA as well mechanism action determination.Antiulcer screenings crude extract, aqueous fraction, and bulked VLC fractions were performed using vivo vitro models. Docking was carried out by PyRx.Crude extract (HA; 1 mg/mL) fraction H. (HAA; showed an acid neutralizing capacity (MEq) 0.3948 0.4035,...

10.1055/a-2132-6475 article EN Drug Research 2023-08-25

Tectona grandis L. f. (Lamiaceae) is famous for timber production and has been used in traditional medicine treating bronchitis, liver-related roubles, urinary discharge amongst other diseases. Methanol extract of the stem bark was investigated vivo antiophidian assay against Bitis arietans Naja nigricollis. Also, chromatographic fractions were subjected to cytotoxicity tests using tadpole model antiarthritic by proteinase inhibition. Chromatography crude methanol afforded three highly polar...

10.4314/epj.v35i2.2 article EN Ethiopian Pharmaceutical Journal 2020-11-03
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