Background: Modification of some crude extracts have improved the stability, functional properties and process ability their bioactive. Objective: To fabricate bioactive from Securidaca longipedunculata root bark compare its activities with extract. Methods: Modified extract was fabricated using microencapsulation freeze-drying technique, evaluated. Results: Fourier Transform Infrared Spectroscopy evaluation showed similar leading peaks in extracts, indicating absence chemical alteration...

Charcoal-tree, Trema orientale (L.) Blume (Cannabaceae) (syn. T. orientalis) has a range of uses in African traditional medicine such as the treatment respiratory ailments, gonorrhea, yellow fever, and toothache, while root bark is used traditionally to induce labour. This study evaluated possible contractile effect methanol (MeOH) crude extract on isolated uterus oestrogenised non-pregnant female rats suspended physiological salt solution (PSS). The MeOH (0.2-4.0 mg/mL) spontaneous uterine...

Hymenocardia acida (H. acida) is an African well-known shrub recognized for numerous medicinal properties, including its cancer management potential. The advent of nanotechnology in delivering bioactive plant extract with poor solubility has improved the drug delivery system, a better therapeutic value several drugs from natural origins. This study aimed to evaluate anticancer properties H. using human lung (H460), breast (MCF-7), and colon (HCT 116) cell lines as well production,...

Cassia siamea (SB) is a common medicinal plant in Southwestern Nigeria, known for its usage the management of cancer among locals. The study aimed to unveil claimed anticancer property SB using cytotoxic bench-top bioassays. Cytotoxicity potential was investigated Raniceps raninus and Saccharomyces cerevisiae bioassay models, radical scavenging strength against DPPH stable also unfolded. fractionation resulted three bulked column fractions (SB1 – 3). SB1 observed induce severe DNA damage...

Male infertility has been associated with oxidative stress-induced and/or microbial induced in some men. The use of medicinal plants to overcome cannot be over emphasized. Hence, the aim this research was isolate antilipid peroxidation (an index usage for treating male infertility) bioactive principle from Momordica charantia using bioactivity-guided isolation.n-Hexane fraction crude ethanol extract obtained by Soxhlet extraction aerial parts (without fruit) bitter melon, M. charantia,...

Abstract Milicia excelsa (Moraceae) plant is used as an antidiarrheal agent in ethnomedicine but there no scientific rationale for its claim. Hence, this study examined the acute toxicity (LD50) and anti-diarrheal effect of methanol root bark extract per oral rats well probable phytoconstituents responsible effect. The LD50 was>5000 mg/kg, suggesting safety. significantly (p<0.05) reduced total number feces wet castor oil-induced diarrhea with percentage inhibitions 41.36 50.88% at 200...

Waltheria indica has been claimed to be used in managing several diseases traditional medicine, although substantial scientific data are not available as regards its safety despite pronounced efficacy management of some ailments. Therefore, methanol leaf extract W. was evaluated for effects on toxicological parameters using experimental animals. However, acute and sub-acute toxicity were carried out animals described by standard methods. Absence death reported after 24 hours single oral...

Drug development begins with medicinal plants as valuable materials. Euphorbia hirta (EH) andNauclea latifolia (NL) are important having applications in the management ofinfectious diseases. This research aimed at evaluating EH and NL leaves for their anthelminticproperty establishment of probable dauer diapause effect induced via interaction daf-12nuclear receptor worms using standard procedures. Powdered plant samples were extractedusing cold maceration 72h. Qualitative, quantitative...

Introduction: Drug development in many countriesbegins with medicinal plants usage as valuable materials. Euphorbia hirta (EH)and Nauclea latifolia (NL)are important having applications the management of infectious diseases, pathogens and various other disorders.Aim: This research aimed at evaluating leaves these for their anthelmintic property establishment probable dauer diapause effect induced via interaction daf-12 nuclear receptor worms (probable mechanism action) using standard...

Spondia mombin stems are traditionally used for managing benign prostatic hyperplasia (BPH). This study examines the impact of microencapsulation on S. mombin’s anti-BPH properties, comparing crude and encapsulated extracts. Microencapsulated particles (S-Mp) were prepared using acacia gum characterized through Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), Fourier Transform Infrared Spectroscopy (FTIR), micromeritic analysis, dissolution studies. The activity S-Mp, blank...

Hymenocardia acida (HA) is one of the numerous medicinal plants in Nigeria with ethnomedicinal history usage treatment ulcer. The study aimed at isolating antiulcer principle(s) from stem bark HA as well mechanism action determination.Antiulcer screenings crude extract, aqueous fraction, and bulked VLC fractions were performed using vivo vitro models. Docking was carried out by PyRx.Crude extract (HA; 1 mg/mL) fraction H. (HAA; showed an acid neutralizing capacity (MEq) 0.3948 0.4035,...

Traditional herbal methods of birth control have been used by many traditions for hundreds years because they offer several benefits over modern like synthetic hormones, intrauterine devices (IUD), and surgery. This literature review set out to determine which African medicinal plants are as contraceptives, with the most emphasis on Nigeria some phytochemical constituents that implicated in anti-fertility. In this research, we an e-library search pertinent books filter published topic...

<title>Abstract</title> Senna siamea/Cassia siamea (SS) has been used by the locals for management of malaria over years. The aim research is to experimentally justify usage different extracts in treatment using both vitro and vivo models unveiling probable mechanism action. Aqueous extract SS (AQ) was observed possess a weak antiplasmodial activity due 10.20 ± 2.52% 1.44 0.52% suppression curation, respectively. Upon subjection confirmatory bioassay, diethyl ether (DeE) showed IC50 0.0650...

Celosia trigyna is a well-known vegetable used in the preparation of many indigenous soups Southwestern Nigeria. The aim this study was to evaluate anticancer property C. crude and solvent fractions using antioxidant, cytotoxic bench-top bioassays, cancer cell line experiments. Cytotoxicity carried out Raniceps ranninus, Saccharomyces cerevisiae, Sorghum bicolor models, as well cytotoxicity studies against human breast (MCF), colon (HCT116), lung (H460) lines; radical scavenging potential...

The cytotoxicity, anti-proliferative and antioxidant effects of leaves Heliconia psittacorum Ficus coronata were studied using standard models. Concentration-dependent activity (P≥0.5) which became maximal at 5mg/ml was observed for the methanol extract, chloroform aqueous fractions both plants every incubation period. Growth inhibition guinea corn seeds (anti-proliferative activity) 48 72h. was: extract &gt; fraction H. psittacorum, F. coronata. Their fraction: (LC50, 5.0 mg/ml) 6.5 more...

The use of traditional medicines has been observed to increase globally. search for new antimicrobial agents increased as a result in microbial infections well resistance. phytochemical and antibacterial activities ethanolic methanolic extract leaves stem Eucalyptus torelliana was investigated detect the presence secondary metabolites also evaluate their potential. constituents powdered were determined using standard methods. susceptibility bacteria from different sources agar diffusion...

Background: Biomaterials exhibit different functional properties. The aim of this study is to formulate direct compressible diclofenac sodium tablet using modified pseudostem cellulose and starch complex. Methods: Cellulose was extracted from Musa paradisiaca acid-hydrolysis fermentation techniques. evaluated FT-IR analysis. Avicel pH-101 used as control cellulose. Micromeritic properties the were tapped consolidation technique. Co-milling heat technique produce polymer-alloy 21.7, 43.4 or...

Tectona grandis L. f. (Lamiaceae) is famous for timber production and has been used in traditional medicine treating bronchitis, liver-related roubles, urinary discharge amongst other diseases. Methanol extract of the stem bark was investigated vivo antiophidian assay against Bitis arietans Naja nigricollis. Also, chromatographic fractions were subjected to cytotoxicity tests using tadpole model antiarthritic by proteinase inhibition. Chromatography crude methanol afforded three highly polar...

Experimental paralysis was induced intramuscularly (i.m) in rats , using Suxa(1.08mg/kg ) Deca (1.08mg/kg normotensive weighing150-180g±2.5g (n=8).Various concentrations of these drugs ranging from (0.36—1.08mg/kg) were used order to assess at what will spastic sustained without death. Similarly, dose response effect examined and the onset action( ie time taken observe manifestation pain death recorded. In some experiments, equimolar Suxa(1.08mg/kg) Deca(1.08mg/kg) reaction time(RT) potency...