A5100439691- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Brain Metastases and Treatment
- Vascular Tumors and Angiosarcomas
- Urologic and reproductive health conditions
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Cancer, Lipids, and Metabolism
- Drug-Induced Adverse Reactions
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Renal and related cancers
- Brain Tumor Detection and Classification
- Prostate Cancer Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
Sun Yat-sen University
2020-2025
Sun Yat-sen University Cancer Center
2020-2025
Tianjin Medical University
2025
Renji Hospital
2025
Chinese University of Hong Kong
2024
University of Hong Kong
2024
China Medical University
2024
Fourth Affiliated Hospital of China Medical University
2024
Montefiore Medical Center
2022
Guizhou Provincial People's Hospital
2020
Clear cell renal carcinoma (ccRCC) is one of the most common and aggressive malignancies urinary system.Despite being first-line treatment for advanced ccRCC, vascular endothelial growth factor receptor inhibitors (VEGFRis) face significant limitations due to both initial acquired resistance, which impede complete tumor eradication.Using a CRISPR/Cas9 library screening approach, MAP2K2 was identified as resistance-associated gene three prevalent VEGFRis (Sunitinib, Axitinib, Sorafenib).A...
Few studies have focused on the prognosis of patients with hepatocellular carcinoma (HCC) Barcelona Clinic Liver Cancer (BCLC) stage 0‒C in terms early recurrence and 5-years overall survival (OS). We sought to develop nomograms for predicting 5-year OS after curative resection HCC, based a clinicopathological‒radiological model. also investigated whether different treatment methods influenced recurrence.Retrospective data, including clinical pathology, radiology, follow-up were collected...
Purpose: No previous researches have extracted radiomics features from susceptibility weighted imaging (SWI) for biomedical applications. This research aimed to explore the correlation between histopathology of hepatocellular carcinoma (HCC) and SWI.
There are limited treatment options for patients with metastatic nasopharyngeal carcinoma (mNPC) after failure of platinum-based chemotherapy. In this trial, we assessed the efficacy and safety sintilimab plus bevacizumab in mNPC where chemotherapy has been ineffective.This was a single-centre, open-label, single-arm, phase 2 trial Guangzhou, China progressed at least one line systemic therapy. Eligible were between 18 75 years old, histologically confirmed differentiated or undifferentiated...
To explore the value of intravoxel incoherent motion (IVIM) sequences in predicting intra-tumoral tertiary lymphoid structures (TLSs). This prospective study pre-operatively enrolled hepatocellular carcinoma (HCC) patients who underwent magnetic resonance imaging including IVIM sequences, between January 2019 and April 2021. Intra-tumoral TLSs presence was assessed on pathological slide images. Clinical radiological characteristics were collected. quantitative parameters radiomics features...
A significant proportion of breast cancer patients showed receptor discordance between primary cancers and brain metastases (BCBM), which significantly affected therapeutic decision-making. But it was not always feasible to obtain BCBM tissues. The aim the present study analyze status matched establish radiomic signatures predict BCBM.The 80 resected were retrospectively analyzed. Radiomic features extracted using preoperative MRI (contrast-enhanced T1-weighted imaging, T2-weighted T2...
Background: Patients with microvascular invasion (MVI)-positive hepatocellular carcinoma (HCC) have shown promising results adjuvant hepatic arterial infusion chemotherapy (HAIC) FOLFOX after curative resection. We aim to develop an imaging-derived biomarker depict MVI-positive HCC patients more precisely and promote individualized treatment strategies of HAIC. Materials Methods: were identified from five academic centers utilized for model development (n=470). Validation cohorts pooled a...
Abstract Background Errors have seldom been evaluated in computer-aided detection on brain metastases. This study aimed to analyze false negatives (FNs) and positives (FPs) generated by a metastasis system (BMDS) readers. Methods A deep learning-based BMDS was developed prospectively validated multicenter, multireader study. Ad hoc secondary analysis restricted the prospective participants (148 with 1,066 metastases 152 normal controls). Three trainees 3 experienced radiologists read MRI...
Background The metastatic vascular patterns of hepatocellular carcinoma (HCC) are mainly microvascular invasion (MVI) and vessels encapsulating tumor clusters (VETC). However, most existing VETC‐related radiological studies still focus on the prediction VETC status. Purpose This study aimed to build compare VETC‐MVI related models (clinical, radiomics, deep learning) associated with recurrence‐free survival HCC patients. Study Type Retrospective. Population 398 patients (349 male, 49 female;...
The relevance of Epstein-Barr virus (EBV) in gastric carcinoma has been represented by the existence EBV-encoded small RNA (EBER) tumor cells and prognostic significance cancer, while adenocarcinoma represents most frequently occurring malignancy.To observe capacity radiomic features extracted from contrast-enhanced computed tomography (CE-CT) images to differentiate EBER-positive EBER-negative ones.A total 54 patients with (EBER-positive: 27, EBER-negative: 27) were retrospectively...
Bladder cancer is one of the most commonly diagnosed urinary cancers worldwide. Although muscle-invasive bladder (MIBC) accounts for only 25% cases, it has a high recurrence rate and poor prognosis, especially among high-grade cases. Despite existence some molecular markers, there clear clinical need robust prediction model that can assist in patient management therapeutic decision-making. Therefore, we aimed to use public databases develop such an effective assessment model.
Acute eosinophilic pneumonia (AEP) is an acute febrile disease with good prognosis. It often manifested as cough, dyspnea and fever, sometimes may also myalgia. However, there are no reports of AEP sepsis-like symptoms arthralgia, joint stiffness, lymph node enlargement, transient rashes abnormal liver function in the literature. A male patient was admitted to our hospital. He presented arthralgia had rashes, enlargement mild function. The counts white blood cells eosinophils were increased...
The present study aimed to explore the optimal chemotherapy strategy for locoregionally advanced children and adolescent nasopharyngeal carcinoma (LcaNPC), based on level of pretreatment plasma Epstein-Barr virus DNA (pEBV-DNA) in era intensity modulated radiation therapy (IMRT).This real-world, retrospective consecutively reviewed patients younger than 22 years old from 2006 2016 Sun Yat-sen University Cancer Center. Kaplan-Meier method with log-rank test Cox regression model were used...
Objective Developing a follow-up strategy to reduce unnecessary prostate biopsies in patients with specific antigen (PSA) ranging from 4 10 ng/ml based on the new model. Methods In first stage, 436 PSA who had undergone transrectal ultrasound (TRUS)-guided biopsy were evaluated. PSA, free (fPSA), digital rectal examination (DRE) findings, ultrasonic hypoechoic mass, microcalcifications, volume (PV), density (PSAD) and age, regarded as predictive factors. In order select independent...