A5101572431- Nanoplatforms for cancer theranostics
- Advanced Numerical Methods in Computational Mathematics
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Numerical methods in engineering
- Numerical methods for differential equations
- Differential Equations and Numerical Methods
- Environmental remediation with nanomaterials
- Water Quality Monitoring and Analysis
- Anaerobic Digestion and Biogas Production
- Microbial Metabolic Engineering and Bioproduction
- Immune Cell Function and Interaction
- Advanced Mathematical Modeling in Engineering
- Adsorption and biosorption for pollutant removal
- Microbial Fuel Cells and Bioremediation
- Cardiac Fibrosis and Remodeling
- Nanoparticle-Based Drug Delivery
- Tryptophan and brain disorders
- Biofuel production and bioconversion
- Protease and Inhibitor Mechanisms
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Microbial Metabolites in Food Biotechnology
- Photodynamic Therapy Research Studies
Shandong University
2014-2025
Shandong Provincial Hospital
2007-2024
Shandong First Medical University
2021-2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Donghua University
2024
Children's Hospital of Chongqing Medical University
2023
Army Medical University
2023
Chongqing Medical University
2023
Pearl River Hydraulic Research Institute
2021
Abstract Although immunotherapy has revolutionized cancer therapy by providing efficient tumor growth suppression, long‐term protection from recurrence as well minimized side effects, the low response rate significantly limits clinical application of in board types solid tumors. In order to improve therapeutic efficacy, conventional therapies including radiotherapy, chemotherapy, phototherapy and chemodynamic are employed combine with elicit stronger antitumor immune responses. Polymer...
The antitumor immune response involves a cascade of three phases, namely, antigen presentation (Phase I), lymphocyte activation and proliferation/differentiation II), tumor elimination III). Therefore, an ideal immunotherapy nanoplatform is one that can simultaneously execute these phases. However, it great challenge to develop single which deliver individual immunoagent their on-demand target sites for tailoring phases because the different restricted by Herein, first time we reported...
The short lifetime and easy quick elimination of the near-infrared (NIR) dye new indocyanine green (IR820) in body restrict its practical application as a photothermal agent cancer therapy. Meanwhile, drawback poor water solubility chemotherapeutic drug paclitaxel (PTX) largely restricts clinical applications. Herein, we, for first time, combined IR820 PTX an "all-in-one" fluorescence imaging-guided chemo–photothermal therapy (PTT) platform by rational design novel pH- enzyme-sensitive...
Abstract Current programmed death‐1 ligand (PD‐L1)‐based therapy focuses on local tumors. However, circulating exosomal PD‐L1 possesses inherent anti‐PD‐L1 blockade resistance and dominates tumor metastasis, playing a critical role in systemic immunosuppression. Therefore, the efficacy of immune checkpoint depends simultaneously decreasing tumoral PD‐L1. such therapeutic platforms have never been reported so far. Herein, checkpoint‐regulatable niche created by an injectable hydrogel is to...
Owing to the insidious onset of ovarian cancer, most patients are in advanced stage with extensive peritoneal metastasis when they diagnosed. Treatment from cancer remains a significant challenge. Inspired by massive macrophages environment, here, we reported an artificial exosome-based peritoneal-localized hydrogel domesticate as therapeutic target for realizing potent therapy, where exosomes derived genetically sialic-acid-binding Ig-like lectin 10 (Siglec-10)-engineered M1-type were...
Abstract T cell exhaustion caused by mitochondrial dysfunction is the major obstacle of cells‐based cancer immunotherapy. Besides exhausted cells, insufficient histocompatibility complex class I (MHC I) on tumor cells leads to inefficient recognition compromising therapeutic efficacy. Therapeutic platform regulate and MHC expression for boosting immunotherapy has not been realized up date. Herein, an injectable hydrogel designed simultaneously tune amplified The in situ constructed site...
Potentiating systemic immunity against breast cancer is in the most urgent demand as less sensitive to immune checkpoint blockade. Although phototherapy and some chemotherapy can trigger immunogenic cell death (ICD) for T cell-mediated antitumor response, their immunotherapy efficacy severely restricted by insufficient phototherapeutic capability severe multidrug resistance (MDR). Inspired both hypersensitivity key role of MDR mitochondria, a rationally engineered amplifier via...
In this paper, potato starch wastewater as culture medium was treated by the oleaginous yeast Lipomyces starkeyi to biosynthesize microbial lipid. The result indicated that carbon source types, concentration, nitrogen inoculum size, and cultivation time all had a significant effect on cell growth lipid accumulation in batch cultures. A measure of 120 g/L glucose 3.0 (NH4)2SO4 10% incubation 96 h cultivated shaking flask at 30 °C were found be optimal conditions not only for but also...
A carrier-free nanodrug was designed to amplify photothermal therapy via interfering with the mitochondrial metabolism, demonstrating a promising metabolism-regulating approach for boosting therapy.
The present study was designed to examine the changes of MMP-2/TIMP-2 in hearts streptozotocin-induced diabetic rats and gain insight into their roles extracellular matrix (ECM) remodelling on an experimental animal model cardiomyopathy.Sixteen male Wistar were randomly divided two groups: normal control rats. Diabetes mellitus induced by streptozotocin injection. All fed with standard chow water ad libitum for 4 weeks. At weeks associated a lower body weight (BW) heart (HW) but higher...
Abstract Triple‐negative breast cancer (TNBC) is the most aggressive subtype, which often results in distant metastasis and dismal prognosis. Unfortunately, current treatments for TNBC are not effective due to its resistance immunotherapy. Recent studies indicate that B7‐H4 immune checkpoint overexpression inflammation‐initiated neutrophil extracellular traps (NETs) closely associated with poor immunotherapy outcome of TNBC. This study finds a checkpoint‐based photodynamic nanodrug combined...