A5103186744- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Plant responses to elevated CO2
- MicroRNA in disease regulation
- Advanced Sensor and Energy Harvesting Materials
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Greenhouse Technology and Climate Control
- Monoclonal and Polyclonal Antibodies Research
- Plant Physiology and Cultivation Studies
- Plant Stress Responses and Tolerance
- Postharvest Quality and Shelf Life Management
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- Cervical Cancer and HPV Research
- Molecular Communication and Nanonetworks
- Agronomic Practices and Intercropping Systems
- Plant Pathogenic Bacteria Studies
- Radioactive element chemistry and processing
- Plant Growth Enhancement Techniques
- Metal Extraction and Bioleaching
- Dielectric materials and actuators
- Molecular Biology Techniques and Applications
- Metastasis and carcinoma case studies
Chongqing Medical University
2023-2025
Xian Yang Central Hospital
2024
Xi'an Technological University
2021-2023
Harbin Medical University
2020-2022
Ministry of Education of the People's Republic of China
2021
Sichuan Agricultural University
2020-2021
MS Technology (United States)
2021
East China Normal University
2021
Fudan University
2018
Sichuan University
2017
Abstract Laryngeal squamous cell carcinoma (LSCC) is a highly malignant tumor originated from respiratory system. Although there have been many improvements in therapy until now, reducing the high mortality remains difficult. Understanding cellular heterogeneity of LSCC could contribute to improve this problem. Single‐cell RNA sequencing was applied dissect composition and molecular characteristics tissues. Immunohistochemistry staining tissues performed identify spatial location cells....
Abstract The role of exogenous methyl jasmonate (MeJA) in alleviating drought stress was investigated on Huangguogan. Except for intercellular CO2 concentration, MeJA had little effect net photosynthetic rate, stomatal conductance, and transpiration rate under stress. Compared with stress, significantly alleviated the decrease chlorophyll content. However, a/b ratio increased. increased proline soluble sugar contents, decreased O2 −· H2O2 levels, SOD POD activities. In addition, MDA content...
Human papillomavirus (HPV) is a significant risk factor for head and neck squamous cell carcinoma (HNSCC). HPV+ HNSCC patients have higher survival rate, which may be related to its unique tumor microenvironment. Exosomes are emerging as communication tool between cells the microenvironment, including cancer-associated fibroblasts (CAFs). In this study, 111 clinical samples tissues public sequencing data were analyzed. Our study found fewer CAFs infiltrated in HNSCC, poor CAF infiltration...
Abstract Human papillomavirus (HPV) is an important etiological factor of head and neck squamous cell carcinoma (HNSCC). HPV + HNSCC patients usually have a better prognosis, which probably results from the higher infiltration B lymphocytes. This study was purposed to detect lymphocyte subsets correlation between prognosis in HPV‐related HNSCC. In this study, 124 513 − samples were obtained Gene Expression Omnibus (GEO) database The Cancer Genome Atlas (TCGA) for transcriptomic analysis....
T cell receptor (TCR)-engineered cells targeting neoantigens originated from mutations in KRAS gene have demonstrated promising outcomes clinical trials against solid tumors. However, the challenge lies developing tumor-specific TCRs that avoid cross-reactivity with self-antigens to minimize possibility of severe toxicities. Current research efforts been put towards strategies eliminate TCR off-target recognition. Naive repertoire was used for screening KRASG12D-reactive TCRs. Specific were...
<title>Abstract</title> <bold>Background</bold> Public neoantigens, including KRAS, TP53, and PIK3CA mutations, which are shared across various tumor types, have demonstrated significant immunogenicity offer great promise for cancer immunotherapy. Clinical trials targeting these public neoantigens yielded encouraging results, regression prolonged relapse-free survival. This study evaluates the HLA binding properties of T cell epitopes derived from to identify optimal target, further develops...
High temperature stress seriously limits the yield and quality of wheat. Trehalose, a non-reducing disaccharide, has been shown involved in regulating plant responses to variety environmental stresses. This study aimed explore molecular regulatory network exogenous trehalose improve wheat heat tolerance through RNA-sequencing technology physiological determination. The data RNA-seq showed that reduced malondialdehyde content relative conductivity roots, affecting phenylpropane biosynthesis,...
Abstract Hotspot driver mutations presented by human leukocyte antigens might be recognized anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mutations, such as PIK3CA H1047L , may serve emerging targets for cancer immunotherapies. NetMHCpan V4.1 was utilized predicting neoepitopes mutation. Using in vitro stimulation, antigen-specific cells targeting the HLA-A*11:01-restricted mutation were isolated healthy donor-derived...
In this study we analysed the influence of drought stress on leaf morphological characteristics, osmotic adjustment substances, antioxidant enzymes, and resistance-related photosynthetic physiological indices Harumi tangor plants grafted onto Poncirus trifoliata (Pt), Citrus junos (Cj), tangerine (Ct). The relative water content area three rootstocks decreased with increasing stress, smallest decrease in Cj. conductivity malondialdehyde increased stress. Proline, total soluble sugar,...
Pyrolusite leaching slag is a Fe-containing generated from pyrolusite process with SO2. Recovery of iron the not only has economic benefit, but also prevents secondary pollution to environment. A novel lab-scale cyclic for recovering was introduced. The contains two steps: (1) leached oxalic acid and [Fe(C2O4)n](3−2n)+ solution generated; (2) irradiated by ultraviolet ferrous oxalate precipitation were obtained. effect operation parameter on irradiation studied separately. In process,...
To develop efficient biocontrol agents, it is essential to investigate the response of soil-borne plant pathogens such agents. For example, Ralstonia solanacearum, tomato wilt pathogen, antimicrobial metabolites Pseudomonas fluorescens unknown. Thus, we assessed effects P. SN15-2 fermentation broth on R. solanacearum by transmission electron microscopy and transcriptome technology. RNA sequencing identified 109 155 genes that are significantly upregulated downregulated, respectively, in...
Abstract The experimental material in the experiment was citrus seedling of Huangguogan. An conducted to study effects fulvic acid on photosynthetic characteristics seedlings under drought stress. Portable photosynthesis meter (L1-6400) used determine net rate and chlorophyll fluorescence. results showed that P n spraying with 200, 400, 600 mg ·L -1 higher than control group, which increased increase concentration acid. With concentration, F o , m v q P, ’/ ’ PSII NPQ all significantly,...
Driven by the loss of bone calcium, elderly are prone to osteoporosis, and regular routine checks on status necessary, which mainly rely testing equipment. Therefore, wearable real-time healthcare devices have become a research hotspot. Herein, we designed high-performance flexible ultrasonic system using axial transmission technology based quantitative ultrasound theory. First, new rare-earth-element-doped PMN-PZT piezoelectric ceramic was synthesized solid-state reaction, characterized...
Abstract In this experiment, Huangguogan was used as the material. The effects of different planting densities on diurnal variation microenvironment in citrus orchard studied, and thekey research findingsare below. environmental factors, including light, daily average temperature soil moisture, increased with decrease density. Compared density 2×3m, thephotosynthetically active radiation(PAR short), air temperature, moisture 4×5m by 423.7%, 5.5%, 2.18% 4.9%. Air CO 2 concentration humidity...
Gastrointestinal stromal tumors (GISTs) typically occur in the stomach and proximal small intestine but can also be found any other part of digestive tract, including abdominal cavity, albeit rarely. In present case, tumor was resected endoscopically through anterior gastric wall. Computed tomography (CT) scan gastroscopy a 60-year-old woman revealed submucosal lesions body. The possibility considered more likely. endoscopic surgery performed under endotracheal anesthesia. After solution had...
<title>Abstract</title> Background: T cell receptor (TCR)–engineered cells targeting neoantigens originated from mutations in KRAS gene have demonstrated promising outcomes clinical trials against solid tumors. However, the challenge lies developing tumor-specific TCRs that avoid cross-reactivity with self-antigens to minimize possibility of severe toxicities. Current research efforts been put towards strategies eliminate TCR off-target recognition. Methods: Naive repertoire was used for...
Abstract In this study, methyl jasmonate (MeJA) was sprayed on the fruits of Huangguogan in shimian county two different ways (whole tree spraying and fruit spraying) to study effect MeJA postharvest quality Huangguogan. The consequence showed that, compared with check (CK), each treatment could improve quality, 10 μmol·L -1 MeJAspayed Huangguoganperformed best. It significantly increased sugar content, Vc total soluble solid (TSS short) content acid ratio Huangguogan, meanwhile decreased...
Abstract HPV (Human papilloma virus) is a kind of small double-stranded DNA viruses which extremely associated with different cancers. The roles plays in the host were gradually identified through interaction between it (including its early genes) and RNA. In recent years, increasing numbers studies HPV-related cancers have been published showing relationship Here, we present database named HRRD, contains regulatory RNA (mRNA, miRNA lncRNA). information was extracted from 10,761 papers...
As an important content of enterprise management, workflow management is closely related to development and business completion. Through the overall situation, establishing a system suitable for enterprise's production can help enterprises establish good environment. In order solve problems low efficiency, unreasonable resource allocation impossible real-time tracking price cost in manufacturing enterprises, this paper proposes priced timed Petri net based on study time nets nets. According...
In order to study the effect of different planting areas on color Pomelo cv. Huangjinmiyou fruit, Pujiang and Guang’an were used in this experiment. Brightness, red green deviation blue yellow exocarp, mesocarp pulp parts test samples measured, composite index difference was calculated. The results showed that comprehensive exocarp from two changed almost synchronously. But it negative at 90 days after anthesis positive 120 pomelo. It still 150 pomelo until 180 anthesis. reflects fruit...
Abstract This experiment used Huangjinmiyou and Sanhongmiyou as materials to studythe accumulation of phenolic substances during fruit developmentin different parts pomelo (exocarp, mesocarp pulp) via Folin-Ciocalteuassay. The results showed that the total content (TPC) was slightly higher than .The sequence TPC in wasmesocarp> exocarp>pulp. three reached maximum on 60th day. aimed at two popular varieties their normal rules phenols changing development differences, which consummated...