A5075317338- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Cancer survivorship and care
- Advanced Breast Cancer Therapies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Biomedical Text Mining and Ontologies
- Cancer Genomics and Diagnostics
- Reproductive Biology and Fertility
- FOXO transcription factor regulation
- PARP inhibition in cancer therapy
- Optical Coherence Tomography Applications
- RNA modifications and cancer
- Cutaneous Melanoma Detection and Management
- Renal and related cancers
- Pluripotent Stem Cells Research
Ospedale L. Bonomo
2024
Istituto Tumori Bari
2016-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2023
Institute of Cell Biology and Neurobiology
2020
Shanghai Cell Therapy Research Institute
2019
University of Bari Aldo Moro
2013-2015
BackgroundGene expression profiling (GEP) studies recognized a prognostic role for tumor microenvironment (TME) in diffuse large B-cell lymphoma (DLBCL), but the routinely adoption of stromal signatures remains limited.Patients and methodsHere, we applied computational method CIBERSORT to generate 1028-gene matrix incorporating 17 immune cytotypes. Then, carried out deconvolution on publicly available GEP data 482 untreated DLBCLs reveal associations between clinical outcomes proportions...
Cancer patients are a population at high risk of contracting COVID-19 and, also developing severe complications due to the infection, which is especially true when they undergoing immunosuppressive treatment. Despite this, had still go hospital receive chemotherapy during lockdown. In this context, we have evaluated psychological status onco-hematological outpatients receiving infusion and not deferrable anti-neoplastic treatment for lymphoproliferative neoplasms, with aim both measuring...
Breast cancer (BC) cells secrete soluble factors that accelerate osteoclast (OC) differentiation, leading to the formation of osteolytic bone metastases. In BOLERO-2 trial, BC patients with involvement who received Everolimus had a delayed tumor progression in skeleton as result direct OC suppression through inhibition mTOR, addition general suppressor effect on cells. Here, we explored Everolimus, mTOR inhibitor, pro-OC paracrine activity Both MDA-MB-231 and MCF-7 cell lines were incubated...
Tumor-infiltrating lymphocytes (TILs) are a valuable indicator of the immune microenvironment that plays central role in new anticancer drugs. TILs have strong prognostic triple negative breast cancer (TNBC). Little is known about interaction with androgen receptor (AR) and forkhead box A1 (FOXA1). We analyzed relationships between TIL levels, AR, FOXA1 expression their clinical significance TNBC patients. Further, we investigated other biomarkers like programmed cell death ligand-1 (PD-L1),...
One of the main problems in analysis real data is often related to presence anomalies. Namely, anomalous cases can both spoil resulting and contain valuable information at same time. In cases, ability detect these occurrences very important. biomedical field, a correct identification outliers could allow development new biological hypotheses that are not considered when looking experimental data. this work, we address problem detecting gene expression data, focusing on microarray analysis....
The role of macrophages (Mo) and their prognostic impact in diffuse large B-cell lymphomas (DLBCL) remain controversial. By regulating the lipid metabolism, Liver-X-Receptors (LXRs) control Mo polarization/inflammatory response, pharmacological modulation is under clinical investigation to treat human cancers, including lymphomas. Herein, we surveyed LXRs DLBCL for purposes. Comparing bulk tumors with purified malignant normal B-cells, found an intriguing association NR1H3, encoding LXR-α...
// Laura Schirosi 1 , Annalisa Mazzotta Giuseppina Opinto Rosamaria Pinto 2 Giusi Graziano 3 Stefania Tommasi Livia Fucci 4 Giovanni Simone and Anita Mangia Functional Biomorphology Laboratory, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy Molecular Genetics Scientific Direction, Pathology Department, Correspondence to: Mangia, email: Keywords : β-catenin, NHERF1, RASSF1A, methylation, metastatic colorectal cancer, Section Received June 30, 2016 Accepted September 21, Published 27,...
It has been recognized that Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) in breast cancer (BC) acts as a tumor suppressor or an oncogenic protein, depending on its subcellular localization. This study aims to correlate NHERF1 expression BRCA1 and PARP1 proteins, investigate their relationship, biological clinical significance. Using immunohistochemistry tissue microarrays, we evaluated NHERF1, 308 BCs including subgroup (n=80) of triple negative (TNBCs). Herein, show nuclear (nNHERF1) was...
In diffuse large B-cell lymphoma (DLBCL), the heterogeneity of response to standard first-line therapy1 largely relies on tremendous biological complexity disease, claiming for an urgent improvement our capacity characterize it at diagnosis guide treatments. Among emerging prognosticators, peculiar cytotypes tumor microenvironment (TME) and relative gene sets were shown predict patients' risk.2–5 We previously recognized prognostic genes reflecting patterns stromal (myofibroblasts [Myo])...
Abstract The unstructured nature of Real-World (RW) data from onco-hematological patients and the scarce accessibility to integrated systems restrain use RW information for research purposes. Natural Language Processing (NLP) might help in transposing reports into standardized electronic health records. We exploited NLP develop an automated tool, named ARGO (Automatic Record Generator Onco-hematology) recognize pathology populate case report forms (eCRFs) pre-implemented by REDCap. was...
Tumor-infiltrating lymphocytes (TILs) are a valuable indicator of the immune microenvironment that plays central role in new anticancer drugs. TILs has strong prognostic triple negative breast cancer (TNBC). Little is known about his interaction with Androgen receptor (AR) and Forkhead box A1 (FOXA1). We analyzed relationships between TIL levels, AR FOXA1 expression their clinical significance TNBC patients. Further, we investigated other biomarkers like programmed cell death ligand-1...
A large percentage of metastatic colorectal cancer (mCRC) patients presents metastasis at the time diagnosis. In last years, great efforts have been made in treatment these with identification different phenotypes playing a key role definition new systemic therapies. Unsupervised hierarchical clustering analysis (HCA) was performed considering clinicopathological characteristics 51 mCRCs. Using immunohistochemistry on tissue microarrays, we assessed expression β-catenin, NHERF1, RASSF1A,...
The metachronic onset of diffuse large B-cell lymphoma (DLBCL) after classic Hodgkin (cHL) is a rare event affecting patients' outcomes. However, although several studies have investigated the prognostic role this event, little known about hypothetical common origin two different neoplastic cells.To investigate possible relationship between DLBCL and cHL, in retrospective study 269 patients with newly diagnosed cHL treated at Bari University Hospital (Italy) 2007 2020, we analyzed data from...
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Background: Diffuse large B cell lymphoma (DLBCL) is a heterogeneous disease with high variability in clinical outcome, genetic features and cells of origin (COO). Gene expression profiling (GEP) studies have identified stromal signatures reflecting extracellular matrix deposition macrophage infiltration as predictive favorable outcome to standard immune‐chemotherapy. However, while reliable gene panel has been recently developed detect compartment, no reproducible biomarkers applicable...
Introduction: Sequencing studies identified mutational drivers in diffuse large B cell lymphoma (DLBCL), capturing outcome difference previously unrecognized patient subsets. However, the lack of routine-applicable genomic approaches limits translation such information to clinic. Currently, molecular prognostication consists origin (COO) determination by Lymph2Cx NanoString assay. We recently developed two independent prognostic signatures incorporating genes reflecting COO, activation...