A5114949771- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemical Synthesis and Reactions
- Cardiac Ischemia and Reperfusion
- Asymmetric Synthesis and Catalysis
- Olfactory and Sensory Function Studies
- Neurological Disorders and Treatments
- Traditional Chinese Medicine Analysis
- Anesthesia and Neurotoxicity Research
- Nicotinic Acetylcholine Receptors Study
- Nerve injury and regeneration
- Hepatitis B Virus Studies
- Barrier Structure and Function Studies
- Vagus Nerve Stimulation Research
- Alzheimer's disease research and treatments
- Blockchain Technology Applications and Security
- Asymmetric Hydrogenation and Catalysis
- Hepatitis C virus research
- Neuroscience and Neuropharmacology Research
- interferon and immune responses
- Flavonoids in Medical Research
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Ginkgo biloba and Cashew Applications
- Ginseng Biological Effects and Applications
Union Hospital
2011-2025
Huazhong University of Science and Technology
2011-2025
Lanzhou University
2024
First Hospital of Jiaxing
2020-2023
Guangdong University of Technology
2023
Hechi University
2023
Jiaxing University
2012-2022
University of Electronic Science and Technology of China
2020-2022
Soochow University
2022
Jinan University
2008-2020
Abstract In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) Western blot. We found that LPS treatment leads to sickness behavior as shown the Morris water maze passive avoidance test, these effects were accompanied microglia activation (labeled ionized calcium binding adaptor molecule-1, IBA-1) neuronal cell loss...
Abstract Background Microglial activation plays an important role in neurodegenerative diseases through production of nitric oxide (NO) and several pro-inflammatory cytokines. Lipoxins (LXs) aspirin-triggered LXs (ATLs) are considered to act as 'braking signals' inflammation. In the present study, we investigated effect LXA 4 (ATL) on infiammatory responses induced by lipopolysaccharide (LPS) murine microglial BV-2 cells. Methods cells were treated with ATL prior LPS exposure, effects such...
Neuronal apoptosis is a regulated intrinsic cell mechanism and common pathological phenomenon after seizures, which involves the protein kinase B/cAMP response element binding / brain derived neurotrophic factor (AKT/CREB/ BDNF) signaling pathway. In this study, we aimed to identify effects of salvianolic acid B (Sal B), major water-soluble component Chinese herb, Danshen, on rats in seizures had been induced by pentylenetetrazole (PTZ) underlying molecular mechanisms mediating these...
Dl-3-N-butylphthalide (NBP) has been used in clinic to treat acute ischemic stroke, however, it not approved stroke patients during the late stage of since effect on functional recovery is confirmed and mechanism clear. In this study, using mice MCAO model, we aim explore two-week NBP treatment after as well underlying mechanism. Our results showed that attenuated improved neurological scores, enhanced performance adhersive remove test, integrity white matter 60-min ischemia 14-day...
Abnormalities in inflammation resolution function are intimately linked to chronic inflammation, and proresolution therapies may offer novel opportunities for IBD treatment. Developmental endothelial locus 1 (DEL-1), a natural modulator of tissue immunity resolution, has not been studied IBD. We aimed investigate the expression functions DEL-1 Assessment patients, murine models, cellular levels. To explore effects acute recovery phases overexpression plasmids, adeno-associated viruses...
Abstract Ischemia–reperfusion (IR) causes oxidative injury and ischemic fiber degeneration due to of the neuron axon. In this study, we explore effect stress on Schwann cells, as a specific peripheral nerve target, using our established rat model for IR injury. Fifty‐six rats were used. Six groups ( N = 8 each) underwent complete hindlimb ischemia 4 h, followed by reperfusion durations 0 3 7 days, 14 28 42 days. One group sham operation 8). We evaluated immunohistochemical labeling...
Autophagy is a lysosome‑mediated cell content‑dependent degradation pathway that leads to enhanced inflammation in an uncontrolled state. This study examined the role of autophagy lipopolysaccharide (LPS)‑induced brain and effects traditional Chinese medicine ligustrazine on LPS‑induced neurocognitive impairment rats. Furthermore, molecular mechanisms by which influences impairments were explored. The production inflammatory mediators interleukin (IL)‑1β tumor necrosis factor (TNF)‑α was...
Neurological injury, as a major pathogenic mechanism in depression, holds significant importance the research and development of antidepressant drugs. Hemerocallis citrina Baroni ( H. ), referred to “Forgetting Sadness Grass,” has been confirmed possess remarkable neuroprotective effects. Studies have identified that total phenolics leaves (HLTP) consist flavonoids phenolic acids numerous studies substantiated effects them. Based on this, we propose HLTP may properties. To confirm this...
Myocardial dysfunction accompanied by severe sepsis could significantly increase the mortality rate of septic patients. This study investigated effects and potential mechanisms sevoflurane preconditioning on myocardial dysfunction, which was induced lipopolysaccharide (LPS; from Escherichia coli O55:B5; 18 mg/kg) in mice. Results indicated that 1 hour after administration, LPS a significant cell-surface Toll-like receptor 4 (TLR4), cytoplasmic IKKα protein expression, nuclear translocation...
Investigation of the protective effect chrysanthemum extract in ischemic strokes patients is among challenging issues with traditional hospital system general and smart technology-based hospitals particular. In this study, we have evaluated on stroke by detecting severity stroke, neuronal indexes, oxidative stress biomarkers. For purpose, forty-six were randomly divided into control group (n = 30) 30). The received standard treatment, was treated 400 mg/day (200 mg/day, twice/day) basis...
Abstract Dirac cones (DCs) are an important band structure in topological insulators (TIs) for realizing phase transition, and they provide unique ways to artificially regulate wave transport. Herein, we proposed a simple method achieve hierarchy three-dimensional (3D) acoustic TIs with rich controllable transitions. The split of multifold DCs each bulk induced boundary hierarchy, including surface states hinge states. We successfully realized 3D higher-order (HOTIs) that exhibited two-fold...
Abstract Ischemia to nerve can cause fiber degeneration and reperfusion following ischemia [ischemia‐reperfusion (IR)] adds the additional insult of an inflammatory response oxidative injury. Limited information is available on molecular mediators their endoneurial targets. In this study, using a highly reproducible animal model IR injury selective immunolabeling methods [for nuclear factor kappa B (NF‐κB), intercellular adhesion molecule‐1 (ICAM‐1), cytokines, cells] over expanded time...
Abstract As blockchain is increasingly valued, the application of and its security has become a research hotspot. Not only that, more ordinary users are paying attention to beginning trade commodities in cryptocurrencies. The wallet program for manage stores their private keys. Furthermore, key user’s unique credential cryptocurrency blockchain. But now, wallets using passwords authenticate users, which poses potential risk security. To mitigate this risk, paper proposes continuous...
Objective. To assess the association between gene polymorphisms (single nucleotide [SNPs]) of rs8099917 and rs12980602 in IL-28 response to lamivudine treatment naïve Chinese rural patients. Material methods. Three hundred fifty-four chronic hepatitis B (CHB) patients treated with were enrolled this study. Rs8099917 SNPs genotyped using matrix-assisted laser desorption/ionization time flight mass spectrometry. Baseline characteristics genotypes compared 181 173 without response. Results. The...
The global prevalence of inflammatory bowel disease (IBD) is increasing, and mucosal healing the preferred treatment target IBD. Sodium (aS,9 R)- 3-hydroxy-16,17-dimethoxy-15-oxidotricyclo[12.3.1.12,6]nonadeca-1(18),2,4,6(19),14,16-hexene-9-yl sulfate hydrate (SDH) a novel diarylheptane compound, which designed to treat Hence, we investigated potent therapeutic activity SDH against IBD explored underlying mechanisms, determined if safe well-tolerated oral for treatment.We characterized its...
A mild and efficient procedure for the synthesis of α-aminonitriles is achieved by treatment aldimines with trimethylsilyl cyanide catalysed MgI 2 etherate.
Background Peg-Interferon-α treatment is expensive and associated with considerable adverse effects, selection of patients the highest probability response essential for clinical practice. The objective this study was to assess relationship between gene polymorphisms interleukin-28 (IL-28), p21-activated protein kinase 4 (PAK4) interferon in chronic hepatitis B patients. Methods Two hundred forty interferon-naive HBeAg seropositive were enrolled present prospective nested case-control study....
A three-component reaction of aldehydes, amines and allyltributylstannane was efficiently carried out to afford the corresponding homoallylic amine derivatives in presence 20 mol% MgI 2 etherate [(MgI * (OEt ) n ] under mild neutral conditions good excellent yields.