A5074282477- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Head and Neck Cancer Studies
- Vestibular and auditory disorders
- Reconstructive Surgery and Microvascular Techniques
- Infectious Diseases and Mycology
- Oral and Maxillofacial Pathology
- Allergic Rhinitis and Sensitization
- Breast Implant and Reconstruction
- Visual perception and processing mechanisms
- Ear and Head Tumors
- Lung Cancer Treatments and Mutations
- Ophthalmology and Eye Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Reconstructive Facial Surgery Techniques
- Bone Tumor Diagnosis and Treatments
- Dental Radiography and Imaging
- Complementary and Alternative Medicine Studies
- Tracheal and airway disorders
- Facial Trauma and Fracture Management
- Retinal Development and Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
New York University
2005-2023
University Medical Center
2008-2023
Case Western Reserve University
2001-2022
Cleveland Clinic
2022
Louis Stokes Cleveland VA Medical Center
2003-2022
University Hospitals of Cleveland
1998-2022
Icahn School of Medicine at Mount Sinai
2019-2021
Technische Universität Dresden
2020
Advanced Technology Group (Czechia)
2020
Alcoa (United States)
2020
Despite the use of resection and postoperative radiotherapy, high-risk squamous-cell carcinoma head neck frequently recurs in original tumor bed. We tested hypothesis that concurrent administration cisplatin radiotherapy would improve rate local regional control.Between September 9, 1995, April 28, 2000, 459 patients were enrolled. After undergoing total all visible palpable disease, 231 randomly assigned to receive alone (60 66 Gy 30 33 fractions over a period 6 6.6 weeks) 228 identical...
In a series of three consecutive pilot studies carried out between 1977 and 1981 at Wayne State University, Detroit, Michigan, designed to test the feasibility multimodality therapy in patients with previously untreated advanced squamous cell carcinoma head neck, received different induction chemotherapy regimens: cisplatin + Oncovin (vincristine) bleomycin (COB) for two courses; 96-hour 5-fluorouracil (5-FU) infusion courses, or 120-hour 5-FU courses. Over-all response rates (complete...
The combination of cisplatin and 96-hour infusion 5-fluorouracil (5-FU) was evaluated in 30 patients with recurrent (local regional) disseminated histologically proven epidermoid cancer the head neck who failed surgery radiotherapy. Cisplatin 100 mg/M2 intravenous (IV) bolus given on day 1 hydration mannitol diuresis; 5-FU 1000 per for started immediately after 1. All had measurable lesions. Eight (27%) achieved complete response (CR), 13 (43%) partial (PR). Overall rate 70% (8 CR PR)....
One of the most active chemotherapeutic regimens for treatment advanced and recurrent head neck cancer is cisplatin (CACP) + 5-fluorouracil (5-FU) infusion with a response rate 90% in advanced, previously untreated patients 70% disease. Forty-four from two Wayne State University-affiliated hospitals were entered into randomized trial CACP (100 mg/m2) day 1 24-hour 5-FU (1000 days through 4 versus bolus (600 8. Thirty-eight evaluable three induction courses. Response arm was 72% (4/18...
Objective Establish the feasibility of a predictive validity study in sinus surgery simulation training and demonstrate effectiveness Endoscopic Sinus Surgery Simulator (ES3) as device. Study Design Prospective, multi‐institutional controlled trial. Setting Four tertiary academic centers with accredited otolaryngology‐head neck residency programs. Subjects Twelve ES3‐trained novice residents were compared 13 control residents. Methods assessed on performance basic tasks. Their first vivo...
Background A current challenge in osteoporosis is identifying patients at risk of bone fracture. Purpose To identify the machine learning classifiers that predict best osteoporotic fractures and, from data, to highlight imaging features and anatomical regions contribute most prediction performance. Study Type Prospective (cross‐sectional) case–control study. Population Thirty‐two women with prior fragility fractures, mean age = 61.6 body mass index (BMI) 22.7 kg/m 2 , 60 without 62.3 BMI...
Pre-clinical studies have shown that exercise can decrease tumour growth through mobilisation, activation, and increased infiltration of natural killer (NK) CD8+ T cells. It is currently unclear whether this be extrapolated to patients. Therefore, a pilot study was set up examine the feasibility obtaining an additional biopsy generate preliminary data on potential effects immune cell function infiltration. Twenty patients with stage I-III breast cancer receiving neoadjuvant chemotherapy were...
Background Local-regional recurrence of disease remains the major obstacle to cure advanced head and neck cancers. Methods This investigation reviewed data derived from Radiation Therapy Oncology Group (RTOG) protocols #85-03 #88-24 identify characteristics tumors that predicted local-regional following surgery postoperative radiotherapy (RT). Results The presence tumor in two or more lymph nodes, and/or extracapsular spread nodal disease, microscopic-size involvement surgical margins...
Abstract The surgical treatment of chronic inflammatory frontal sinus disease over the past century has varied between intranasal and external procedures. There been constant modification these techniques; however, a single approach that will lead to relief symptoms, eradication with preservation function, minimum deformity not yet attained. functional theory disease, evolution endoscopic techniques, data provided by computed tomography scan have renewed our interest in anatomy lateral nasal...
In a series of three consecutive pilot studies conducted between 1977 and 1982 at Wayne State University, Detroit, Michigan, 191 patients with previously untreated, locally advanced head neck cancer were treated cisplatin (CDDP), vincristine, bleomycin or CDDP 5-fluorouracil (5-FU) infusion before definite surgery radiation. A 39% (75/191) rate complete clinical responses was achieved. Thirty-two the chemotherapy-induced responders underwent radical surgery. Thirteen had no histologic...
A male infant is described showing all the major features of oral-facial-digital syndrome (OFD): lobulated tongue with hypertrophic frena, fibrous bands extending into alveolar clefts, pseudocleft upper lip, cleft palate, hypoplastic alae nasi, dystopia canthorum, various digital anomalies, and typical X-ray appearance skull. partial agenesis corpus callosum a lipoma was indicated by pneumoencephalography angiography. The OFD confined to females. In present case an XXY chromosome...
Sinusitis has been reported as a complication of sinus lift surgery with antral bone augmentation. The procedure involves the creation submucoperiosteal pocket in floor maxillary for placement graft consisting autogenous, allogenic, or alloplastic material. This can result inadvertent tearing mucoperiosteal flap extrusion material into antrum. Obstruction outflow tract by mucosal edema and particulate may sinusitis. We will discuss clinical presentation management 14 cases chronic sinusitis...
Stools from 124 Nepalese children aged 6 to 60 months with diarrhea were examined for organisms of the coccidian genus Cyclospora and other enteric pathogens. Enterotoxigenic Escherichia coli, Giardia Lamblia, Campylobacter species, Cryptosporidium species most common pathogens identified. detected in none 74 < 18 age compared (12%) 50 > or = (P 0.004).
To establish discriminant validity of the endoscopic sinus surgery simulator (ES3) (Lockheed Martin, Akron, Ohio) between various health care provider experience levels and to define benchmarking criteria for skills assessment.Prospective multi-institutional comparison study.University-based tertiary institution.Ten expert otolaryngologists, 14 otolaryngology residents, 10 medical students.Subjects completed ES3's virtual reality curriculum (10 novice mode, intermediate 3 advanced mode...
Chronic rhinosinusitis (CRS) is defined as a condition lasting for period greater than 12 weeks, and manifested by an inflammatory response involving the mucous membranes of nasal cavity paranasal sinuses, fluids within these cavities, and/or underlying bone. The mucosal changes that occur in CRS have been well described, include edema, decreased number ciliated cells, goblet cell hyperplasia. However, may ethmoid bone only recently investigated. We evaluated decalcified specimens from 20...
To determine the incidence and degree of asymmetry in height contour ethmoid roof.Retrospective review direct coronal paranasal sinus computed tomography (CT) scans.Retrospective 200 consecutive CT scans done at New York University Medical Center from July 25, 2000 to October 11, 2000. The fovea ethmoidalis were examined for symmetry between right left sides. When an existed, this difference was quantified.In 19 (9.5%), there on Of these 19, 12 (63.2%) lower side, whereas 7 (36.8%) left....
We report the use of cadaveric human tracheal homograft in treatment severe long segment congenital stenosis children.Five children (aged 5 months-8 years) with life-threatening airway obstruction due to had failed conventional management. All were ventilator dependent or rapidly deteriorating at time surgery, two on extracorporeal membrane oxygenation, and no alternative therapy was available. The stenosed trachea removed posterior trachealis muscle left situ when possible. Surgical...
The use of homeopathy is growing in the United States, but little known about practice patterns physicians using and patients who seek homeopathic care.Data for consecutive patient visits to 27 doctors medicine osteopathy 1992 were collected compared with National Ambulatory Medical Care Survey 1990.Patients seen by younger, more affluent, likely present long-term complaints. Physicians surveyed spent time their patients, ordered fewer tests, prescribed pharmaceutical medications than...
Chronic sinus disease associated with progressive mucosal is often a cause for anosmia. Despite aggressive allergic, medical, and surgical intervention, long-term relief of anosmia has been difficult to document. Fifty patients sought treatment subjective symptoms sinusitis underwent endoscopic surgery. After surgery 52% maintained significant improvement in smell by measures that correlated objective olfactory University Pennsylvania Small Identification test ("UPSIT") results. Of the...
Synechiae formation is a frequent occurrence after endoscopic sinus surgery and may cause symptomatic outflow tract obstruction. Various means are used to reduce the incidence of synechiae formation. These include meticulous operative technique, partial middle turbinate resection, meatus spacers or stents, postoperative debridement. The microdebrider powered rotary shaving device that precisely resects tissue, minimizing inadvertent mucosal trauma stripping. We present 40 cases performed...