Succinate dehydrogenase inhibitors (SDHIs) have emerged in fungicide markets as one of the fastest-growing categories that are widely applied agricultural production for crop protection. Currently, structural modification focusing on flexible amide link SDHI molecules is being gradually identified innovative strategies developing novel highly efficient and broad-spectrum fungicides. Based above features, a series pyrazole-4-acetohydrazide derivatives potentially targeting fungal SDH were...

The pyrazole-4-carboxamide scaffold containing a flexible amide chain has emerged as the molecular skeleton of highly efficient agricultural fungicides targeting succinate dehydrogenase (SDH). Based on above vital structural features inhibitors (SDHI), three types novel pyrazole-4-formylhydrazine derivatives bearing diphenyl ether moiety were rationally conceived under guidance virtual docking comparison between bioactive molecules and SDH. Consistent with verification results comparison, in...

Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral antibacterial activities. Aiming discover novel myricetin analogues with potent activities, a series of containing moiety synthesized, their activities evaluated.Bioassay results indicated that some target compounds exhibited potential Among them, 2, 3a, 3b, 3d, 3f, 3i, 3m 3p excellent against Xanthomonas oryzae pv. Oryzae (Xoo), EC50 values 42.7, 38.6, 20.8, 12.9, 22.7, 27.3, 18.3 29.4 μg/mL,...

Aiming to develop novel antifungal agents with a distinctive molecular scaffold targeting succinate dehydrogenase (SDH), 24 N'-phenyl-1H-pyrazole-4-sulfonohydrazide derivatives were first devised, synthesized, and verified by 1H NMR, 13C high-resolution mass spectrometry (HRMS), single-crystal X-ray diffraction analysis. The bioassays revealed that the target compounds possessed highly efficient broad-spectrum activities against four tested plant pathogenic fungi Rhizoctonia solani (R....

Main observation and conclusion To screen novel antifungal agents targeting the succinate dehydrogenase (SDH), a series of pyrazole‐4‐carbohydrazides were rationally designed, synthesized, characterized under guidance structures inhibitors (SDHIs). Bioassay results in vitro indicated that most target compounds exhibited excellent activity against Rhizoctonia solani ( R. ), Fusarium graminearum F. Botrytis cinerea B. ) Colletotrichum capsica C. ). Compounds 7d, 7l, 7t 7x identified as...

The synthesized pyrazole carboxamide and niacinamide derivatives containing a benzimidazole moiety showed effective inhibition of the fungus <italic>B. cinereal</italic> growth. 3D-QSAR model was built revealed fine predictive ability.

Abstract The identification of different kinds watercolor inks is an important work in the field forensic science. Four ink Spectroscopy data fusion strategies (Fourier Transform Infrared spectroscopy and Raman spectroscopy) combined with a non‐linear classification model (Extreme Learning Machine) were used to identify brand inks. study chose Competitive Adaptive Reweighted Sampling (CARS), Random Frog (RF), Variable Combination Population Analysis‐Genetic Algorithm (VCPA‐GA),...

The dearomatization at the hydrophobic tail of boscalid was carried out to construct a series novel pyrazole-4-carboxamide derivatives containing an oxime ether fragment. By using fungicide-likeness analyses and virtual screening, 24 target compounds with theoretical strong inhibitory effects against fungal succinate dehydrogenase (SDH) were designed synthesized. Antifungal bioassays showed that compound E1 could selectively inhibit in vitro growth R. solani, EC50 value 1.1 μg/mL superior...

Abstract Mechanical ventilation (MV) is an essential life‐saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator‐induced (VIDD). It not clear about mechanism occurrence prevention measures VIDD. Irisin a newly discovered muscle factor that regulates energy metabolism. Studies have shown irisin exhibit protective effects by downregulating endoplasmic reticulum (ER) stress in...

A series of novel fused heterocyclic compounds bearing benzo[4,5]imidazo[1,2-d][1,2,4]triazine 4a-4w were designed and conveniently synthesized via the intermediates 2-(halogenated alkyl)-1H-benzo[d]imidazoles 2a, 2b, 2-((1-(substituted phenyl)hydrazinyl)alkyl)-1H-benzo[d]imidazoles 3a-3g. The structures all target characterized by FT-IR, ¹H NMR, 13C EI-MS, which, structure compound 4n was further determined single crystal X-ray diffraction. crystallized in triclinic system, space group P 1...

A series of quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety were designed, synthesized and evaluated for their biological activities against phytopathogenic microorganisms. Antimicrobial bioassays in vitro indicated that most the target compounds exhibited more significant antibacterial Xanthomonas oryzae pv. (Xoo) than agricultural bactericide thiadiazole-copper. comparative molecular similarity index analysis (CoMSIA) model with cross-validated q2...

Novel pyrrolidine-2,4-dione derivatives were designed based on natural products. Some synthesized compounds showed excellent antifungal activity. Scanning electron microscopy was used to observe mycelium morphology. 3D-QSAR also studied.

A series of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety were designed, synthesized and evaluated for their antibacterial, antifungal antiviral activities. The bioassay results indicated that most target compounds showed good activities against tobacco mosaic virus (TMV) antibacterial Xanthomonas oryzae pv. (Xoo) Ralstonia solanacearum (Rs). Especially, the anti-Xoo effect title 5k (N-(5-methoxybenzo[d]thiazol-2-yl)-2-((5-(2-tolyl)-1,3,4-thiadiazol-2-yl)thio)acetamide)...

penta-1,4-diene-3-one oxime ether and quinazolin-4(3H)-one derivatives possess favorable agricultural activities. Aiming to discover novel molecules with highly-efficient activities, a series of containing scaffold were synthesized evaluated for their antiviral activities.Antiviral bioassays indicated that some title compounds exhibited significant activity against tobacco mosaic virus (TMV). In particular, 8c, 8j 8k possessed appreciable curative activities TMV in vivo, half-maximal...

Abstract A series of quinazolin‐4(3 H )‐one derivatives containing a hydrazide moiety were designed, synthesized and characterized in detail via FT‐IR, 1 NMR, 13 C NMR HRMS spectra. The antifungal activities against Rhizoctonia solani ( Rs ) Fusarium graminearum Fg evaluated vitro . bioassay results indicated that most the title compounds exhibited significant Strikingly, EC 50 values some are obviously superior to positive control carbendazim. Based on , comparative molecular filed analysis...