A5022339560- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Inflammation biomarkers and pathways
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Animal Virus Infections Studies
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Immune responses and vaccinations
- Inflammasome and immune disorders
- Pneumonia and Respiratory Infections
- T-cell and B-cell Immunology
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Bat Biology and Ecology Studies
- Rabies epidemiology and control
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA Interference and Gene Delivery
- SARS-CoV-2 detection and testing
Universität Greifswald
2018-2025
Friedrich-Loeffler-Institut
2018-2025
Max Planck Institute for Infection Biology
2011-2021
Riemser Pharma (Germany)
2021
Institute of Immunology
2020
Universitätsmedizin Greifswald
2019
Charité - Universitätsmedizin Berlin
2014-2017
Max Planck Society
2009-2016
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2006-2010
The molecular mechanisms that control innate immune cell trafficking during chronic infection and inflammation, such as in tuberculosis (TB), are incompletely understood. During active TB, myeloid cells infiltrate the lung sustain local inflammation. While chemoattractants orchestrate these processes increasingly recognized, posttranscriptional events dictate their availability unclear. We identified microRNA-223 (miR-223) an upregulated small noncoding RNA blood parenchyma of TB patients...
Abstract Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis. Pneumococci can be divided into >90 serotypes that show differences in the pathogenicity invasiveness. We tested hypotheses innate immune inflammasome pathway involved fighting pneumococcal pneumonia some invasive types are not recognized by this pathway. human murine mononuclear cells responded to S. expressing hemolytic pneumolysin producing IL-1β. This IL-1β production depended on NOD-like...
Macrophages can be niches for bacterial pathogens or antibacterial effector cells depending on the pathogen and signals from immune system. Here we show that type I II IFNs are master regulators of gene expression during Legionella pneumophila infection, activators an alveolar macrophage-intrinsic response restricts growth pneumonia. Quantitative mass spectrometry revealed both substantially modify Legionella-containing vacuoles, comparative analyses reveal distinct subsets transcriptionally...
General interest in the biological functions of IFN type I Mycobacterium tuberculosis (Mtb) infection increased after recent identification a distinct gene expression signature (TB) patients. Here, we demonstrate that TB-susceptible mice lacking receptor for (IFNAR1) were protected from death upon aerogenic with Mtb. Using this experimental model to mimic primary progressive pulmonary TB, dissected immune processes affected by I. IFNAR1 signaling did not affect T-cell responses, but markedly...
Successful host defense against numerous pulmonary infections depends on bacterial clearance by polymorphonuclear leukocytes (PMNs); however, excessive PMN accumulation can result in life-threatening lung injury. Local expression of CXC chemokines is critical for recruitment. The impact chemokine-dependent recruitment during Mycobacterium tuberculosis infection not fully understood. Here, we analyzed genes encoding M. tuberculosis–infected murine tissue and found that promotes upregulation...
Raccoon dogs might have been intermediate hosts for severe acute respiratory syndrome-associated coronavirus in 2002-2004. We demonstrated susceptibility of raccoon to syndrome 2 infection and transmission in-contact animals. Infected animals had no signs illness. Virus replication tissue lesions occurred the nasal conchae.
The cross talk between host and pathogen starts with recognition of bacterial signatures through pattern receptors (PRRs), which mobilize downstream signaling cascades. We investigated the role cytosolic adaptor caspase recruitment domain family, member 9 (CARD9) in tuberculosis. This was critical for full activation innate immunity by converging signals multiple PRRs. Card9−/− mice succumbed early after aerosol infection, higher mycobacterial burden, pyogranulomatous pneumonia, accelerated...
As a hallmark of tuberculosis (TB), Mycobacterium (MTB) induces granulomatous lung lesions and systemic inflammatory responses during active disease. Molecular regulation inflammation is associated with inflammasome assembly. We determined the extent to which MTB triggers activation how this impacts on severity TB in mouse model. stimulated release mature IL-1β macrophages while attenuated M. bovis BCG failed do so. Tubercle bacilli specifically activated NLRP3 propensity was strictly...
Myeloid cells encompass distinct populations with unique functions during homeostasis and disease. Recently, a novel subset of innate cells, myeloid-derived suppressor (MDSCs), has been described in cancer, which suppresses T-cell responses fosters disease progression. The role MDSCs infection is insufficiently addressed.To examine the presence function experimental pulmonary tuberculosis (TB) further understand immunologic consequences direct interactions between lung bacterial...
Background. New vaccines against tuberculosis (TB) are urgently needed because the only available vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG), fails to protect pulmonary TB in adults. The recombinant ΔureC hly+ BCG (rBCG) is more efficient than parental (pBCG) preclinical studies and has proven safe immunogenic phase I clinical trials.
Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses collectively modify its behavior through the production, release, and detection of signaling molecules. QS molecules can also be sensed hosts, although respective receptors pathways are poorly understood. We describe pattern regulation in host aryl hydrocarbon receptor (AhR) is critically dependent on qualitative quantitative P. quorum. bind AhR distinctly modulate...
The human pathogen Mycobacterium tuberculosis has the capacity to escape eradication by professional phagocytes. During infection, M. resists harsh environment of phagosomes and actively manipulates macrophages dendritic cells ensure prolonged intracellular survival. In contrast other pathogens, it remained difficult capture transcriptome mycobacteria during infection due an unfavorable host-to-pathogen ratio. We infected macrophage-like cell line THP-1 with attenuated surrogate bovis...
Cellular stress has been associated with inflammation, yet precise underlying mechanisms remain elusive. In this study, various unrelated inducers were employed to screen for sensors linking altered cellular homeostasis and inflammation. We identified the intracellular pattern recognition receptors NOD1/2, which sense bacterial peptidoglycans, as general detecting perturbations of homeostasis. NOD1/2 activation upon such required generation endogenous metabolite sphingosine-1-phosphate...