A5113250968- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- S100 Proteins and Annexins
- Acute Ischemic Stroke Management
- Renal and Vascular Pathologies
- Cerebrovascular and genetic disorders
- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Trigeminal Neuralgia and Treatments
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Chemical Reactions and Isotopes
- Botulinum Toxin and Related Neurological Disorders
- Facial Nerve Paralysis Treatment and Research
Sun Yat-sen University
2022-2025
Bridge University
2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
University Medical Center
2024
Hubei Zhongshan Hospital
2024
Wuhan University
2024
Radboud University Nijmegen
2024
Radboud University Medical Center
2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Discontinuation of the deep medullary veins (DMVs) may be an early imaging marker for identifying cognitive impairment caused by cerebral small vessel disease (CSVD). However, this method lacks mechanistic exploration. We aimed to investigate whether DMV score is related CSVD markers and in patients with CSVD. This retrospective study included who completed cognition (e.g., MMSE, MoCA) assessments, underwent MRI scanning (T2-FLAIR white matter hyperintensities (WMH) volume, T1-weighted brain...
BACKGROUND: Hypertension and advanced age are risk factors for arteriosclerotic cerebral small vessel disease (cSVD), a common cause of vascular dementia in elderly individuals. Circulating IGF-1 (insulin-like growth factor 1) levels decrease with linked to age-related cognitive impairment. This study assessed the relationship between serum cSVD severity patients therapeutic effects underlying mechanisms exogenous supplementation rat model. METHODS: Serum MR images were collected from...
Background: Cerebral small vessel disease (CSVD) often manifests with gait impairment, a critical yet overlooked aspect of early progression. Our study is aimed at leveraging wearable sensors and machine learning to analyse characteristics, providing cost‐effective scalable method for CSVD diagnosis. Methods: We collected baseline data from 115 individuals diagnosed 120 community healthy controls. All participants underwent quantitative assessment utilizing the device Ambulosono. The applied...
Chronic hypertension is a major risk factor for cognitive impairment, which can promote neuroinflammation and neuronal loss in the central nervous system. Transforming growth β-activated kinase 1 (TAK1) key molecular component determining cell fate be activated by inflammatory cytokines. This study aimed to investigate role of TAK1 mediating survival cerebral cortex hippocampus under chronic hypertensive conditions. To that end, we used stroke-prone renovascular rats (RHRSP) as models....
Cerebral small vessel disease (SVD) may be associated with an increased risk of depressive symptoms. Serum uric acid (SUA), antioxidant, involved in the occurrence and development symptoms, but mechanism remains unknown. Moreover, relationship between structural brain networks SUA has not been explored. This study examined symptoms patients SVD using graph theory analysis. We recruited 208 inpatients collected fasting blood samples upon admission. Depressive were assessed 24-item Hamilton...
<title>Abstract</title> <italic><bold>Background:</bold></italic> Studies reported a relationship between white matter alterations and apathy in patients with Cerebral Small Vessel Disease (CSVD), the lesions are heterogeneously distributed.<italic><bold> </bold></italic>To identify microstructural associated CSVD using tract-based spatial statistics (TBSS). <italic><bold>Methods:</bold></italic>Forty-eight underwent structural magnetic resonance imaging (MRI) completed clinical assessments...
Abstract Physiological processes within the human body are regulated in approximately 24‐h cycles known as circadian rhythms, serving to adapt environmental changes. Bone rhythms play pivotal roles bone development, metabolism, mineralization, and remodeling processes. exhibit cell specificity, different cells display various expressions of clock genes. Multiple factors, including light, feeding, exercise, temperature, affect diurnal through sympathetic nervous system hormones. Disruptions...
Abstract Background Facial appearance and expressions influence social interaction. However, few studies have reported on the stigma associated with spasms from facial dystonia. This study investigated quality of life for these patients. Methods cross-sectional included 90 patients dystonia (hemifacial spasm [HFS], blepharospasm [BSP], blepharospasm-oromandibular [BOD]; 30 per group) individuals without (control October 2019 to November 2020. All participants underwent stigma, life, mental...