A5102805818- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Cerebrovascular and genetic disorders
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Cancer Mechanisms and Therapy
- Seaweed-derived Bioactive Compounds
- Gout, Hyperuricemia, Uric Acid
- Heme Oxygenase-1 and Carbon Monoxide
- PI3K/AKT/mTOR signaling in cancer
- Fibroblast Growth Factor Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Neuroinflammation and Neurodegeneration Mechanisms
- Gastrointestinal motility and disorders
- Advanced Glycation End Products research
- Immune Cell Function and Interaction
- Psychological Well-being and Life Satisfaction
- Adenosine and Purinergic Signaling
- Health, psychology, and well-being
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience of respiration and sleep
Fujian Medical University
2020-2023
Sun Yat-sen University
2022-2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Jinan Central Hospital
2016-2022
Tsinghua University
2017-2022
Shandong First Medical University
2022
Shandong University
2016-2021
Shandong Provincial Hospital
2019-2021
Yangtze University
2021
First Affiliated Hospital of Zhengzhou University
2018
Circular RNAs (circRNAs) are pervasively expressed circles of non‑coding RNAs. Even though many circRNAs have been reported in humans, their expression patterns and functions remain poorly understood. In this study, we employed a pipeline named RAISE to detect RNA‑seq data. can fully characterize circRNA structure abundance. We evaluated inter-individual variations humans by applying numerous non‑poly(A)-selected identified 59,128 candidates 61 human liver samples, with almost no overlap the...
Irritable bowel syndrome (IBS) is a common functional disease characterized by chronic abdominal pain and changes in movements. Effective therapy for visceral hypersensitivity IBS patients remains challenging. This study investigated the roles of brain-derived neurotrophic factor (BDNF) tyrosine kinase receptor B (TrkB) effect ANA-12 (a selective antagonist TrkB) on an IBS-like rat model.An model was established through neonatal maternal separation (NMS), assessed electromyographic (EMG)...
The prevalence of hyperuricemia (HUA) and gout continues to increase in China. Research suggests that HUA may be related many diseases other than gout. However, further population research is required investigate the association between metabolic syndromes. This study sought an average China, serum uric acid (UA) levels disorders.This multicenter retrospective real-world examined hospital information system data 4 tertiary hospitals 3 provinces patients aged 18 80 years, who had attended at...
Abstract Background Interleukin-33 (IL-33), defined as "alarming", exert diverse functions through signaling via the suppression of tumorigenicity 2 (ST2). However, physiological roles IL-33/ST2 during acetaminophen (APAP)-induced liver injury are still poorly understood by modern medicine (AILI). This research aims to explore relationship between and stimulator interferon (IFN) response cGAMP interactor 1 (STING)-mediated signal transduction. Methods C57BL/6N mice (WT) IL-33-deficient (KO)...
Chronic hypertension is a major risk factor for cognitive impairment, which can promote neuroinflammation and neuronal loss in the central nervous system. Transforming growth β-activated kinase 1 (TAK1) key molecular component determining cell fate be activated by inflammatory cytokines. This study aimed to investigate role of TAK1 mediating survival cerebral cortex hippocampus under chronic hypertensive conditions. To that end, we used stroke-prone renovascular rats (RHRSP) as models....
Cerebral small-vessel disease (CSVD) is the main cause of vascular cognitive impairment (VCI), and accumulation amyloid β-protein (Aβ) may be significantly involved in CSVD-induced VCI. The imbalance between Aβ production clearance believed to an important pathological mechanism deposition Alzheimer disease. In this study, we aimed disclose roles aquaporin 4 (AQP4) neuroinflammation CSVD, which were key factors for production, respectively, effect mesenchymal stem cells (MSCs) on these two...
To understand metformin's effects on fibroblast growth factors (FGFs) and factor receptor 1 (FGFR1), we investigated circulating factor-19 (FGF19), FGF21 levels, FGFR1 in type 2 diabetes mellitus (T2DM). In addition, protein kinase B (Akt) signaling pathway was detected to explain the possible mechanisms. T2DM induced by feeding rats with high-fat diet for 11 weeks, followed a low dose of streptozotocin (STZ, 30-35 mg/kg, intraperitoneally). Control (Con) were fed normal chow; diabetic (DM)...
Global life satisfaction has been consistently linked to physical health. A deeper and culturally nuanced understanding of which domains may be responsible for this association implications developing novel, scalable, targeted interventions improve health at the population level. This cohort study draws participants from China Family Panel Studies (CPFS), a nationally representative 10,044 Chinese adults assess independent associations between three important (and their changes) indicators...
Introduction Paraquat (PQ) is a widely used herbicide which inexpensive and easily accessible for people in rural areas. A small amount of PQ ingestion could be lethal, yet currently, the optimal treatment still controversial. Extracorporeal therapies (ECTR) have been practised poisoning management, though limited evidence obtained to suggest its superiority over conservative therapy. Haemodialysis (HD) haemoperfusion (HP) are most commonly used, while some institutions also choose HP–HD...
Irritable bowel syndrome (IBS) is one of the typical representatives chronic functional visceral pain that lacks effective treatment. Recently, attention has been given to role microglia in IBS, particularly activation spinal and subsequent release Cathepsin S (Cat S), a proteolytic enzyme. However, specific Cat IBS remains be elucidated. The purpose this study investigate mechanisms underlying regulation hypersensitivity IBS-like rats by S.An rat model was developed, sensitivity tested via...
Introduction: This study aimed to collect and evaluate basic information of a stroke screening population in eastern China compare distribution differences risk factors between males females transient ischemic attack (TIA) population. Methods: A standardization the for was performed according an implementation plan high-risk intervention project Shandong Province. Of 231,289 residents, 8,603 patients with previous TIA were identified this cohort analyzed sex differences. Results: In our...
Objective: To introduce a new design needle and device of microcatheter protection for lumbar intrathecal catheterization in rats,and evaluate its feasibility effectiveness.Methods: Sixty pathogen-free adult male Sprogue-Dawley rats were randomly divided into two groups(n=30 each group), the control group (group C) modification group(group M). The traditional puncture device, 20G needle, was used C without extemal shielding protection. microinjection cock M. All assessed motor function on...
Cervical cancer is one of the diseases that severely threaten health women.Epidemiological survey showed HPV infection main condition for development cervical and precancerous lesions.γδT cells,the innate immune cells,are component intraepithelial lymphocyte in female reproductive organs.γδT cells are bridges between adaptive immunity innate.They important anti infection,anti tumor,immune surveillance regulation some researches.γδT were also found to have immunosuppressive effect,which...
Abstract This abstract was withdrawn by the authors.
Objective To explore the effects of vascular risk factors on cognitive function among elderly in community. Methods A cross-sectional study was conducted 1 269 people (aged 65 and over) who were randomly selected from three communities.Through face-to-face interview, assessed by mini-mental state examination(MMSE), blood samples collected for laboratory examination.Logistic regression analysis used to analyze affecting function. Results Age ((73.1±6.6), (71.3±4.9), t=4.603,...
The rationale for undertaking this study is lethality of diabetes mellitus as predicted by 6.7 million deaths in 2021 and immense pharmacological potential Artemisa herba-alba. current research examined how Artemisia herba-alba extract (AHE) affects the peripheral artery disease diabetic rats through lowering advanced glycation end products (AGEs). in-vitro AGE inhibiting AHE was determined spectrofluorimetric method. blood glucose levels HbA1c (A1C) from each group were automatic analyser....