A5041177415- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- ECG Monitoring and Analysis
- Blood Pressure and Hypertension Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Ethics in Clinical Research
- Ion channel regulation and function
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- Cardiovascular and exercise physiology
- Meta-analysis and systematic reviews
- Cardiac Imaging and Diagnostics
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Function and Risk Factors
- Pharmaceutical industry and healthcare
- Acute Myocardial Infarction Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tissue Engineering and Regenerative Medicine
- Lipoproteins and Cardiovascular Health
- Cardiovascular Effects of Exercise
Päijät-Hämeen Keskussairaala
2011-2025
University of Helsinki
2012-2022
Helsinki University Hospital
2013-2022
South Karelia Central Hospital
2014-2021
University of Pennsylvania
2018
Turku University Hospital
2018
Hospital Universitario de La Princesa
2017
Universidad Autónoma de Madrid
2017
Sociedade Brasileira de Cardiologia
2017
Tampere University
2006-2015
AimsAs a part of the Finnish Cardiovascular Study, we tested hypothesis that T-wave alternans (TWA) predicts mortality in general population patients referred for clinical exercise test.
The study was aimed to test the mechanical strength, structural stability, and tissue reactions of optically amorphous crystalline polyetheretherketone (PEEK) plates during a 3-year follow-up in vivo vitro. injection-moulded PEEK were implanted dorsal subcutis 12 sheep, which sacrificed at 6-156 weeks. Thereafter, subjected tensile tests, levels crystallinity assessed by differential scanning calorimetry (DSC). Histological evaluation carried out using paraffin technique. In vitro properties...
Enhanced sympathetic activity at the ventricular myocardium can destabilize repolarization, increasing risk of death. Sympathetic is known to cluster in low-frequency bursts; therefore, we hypothesized that induces periodic changes repolarization. We developed a technique assess effect on repolarization and identified components spectral range (≤0.1 Hz), which termed dynamics (PRD).We investigated physiological properties PRD multiple experimental studies, including swine model steady-state...
To non-invasively measure central haemodynamics, arterial stiffness, cardiac function and vascular resistance, with the subject in supine position during head-up tilt, order to examine haemodynamic changes associated alterations augmentation index, investigate repeatability reproducibility of measurement protocol.Thirty-three healthy volunteers (21-51 years) were investigated using continuous pulse wave analysis from radial artery a tonometric sensor, whole-body impedance cardiography...
Heart failure (HF) is a major global health concern and increasing in prevalence.It affects the larynx breathing À thereby quality of speech.In this article, we propose an approach for automatic detection people with HF using speech signal.The proposed method explores mel-frequency cepstral coefficient (MFCC) features, glottal their combination to distinguish from healthy speech.The features were extracted voice source signal estimated inverse filtering.Four machine learning algorithms,...
The stiffening of arteries is associated with various cardiovascular diseases. Arterial can be studied utilizing arterial pulse wave velocity (PWV), but the absence reliable reference values for PWV has limited its use in clinical practice. aim this study was to establish a range PWV. examined by measuring time difference systolic waves from aortic arch popliteal artery using whole-body impedance cardiography (ICG). population consisted 799 individuals (age 25-76 years), 283 whom had no...
We examined whether quantification of T-wave alternans (TWA) enhances this parameter's capacity to evaluate the risk for total and cardiovascular mortality sudden cardiac death (SCD).The Finnish Cardiovascular Study (FINCAVAS) enrolled consecutive patients (n = 2,119; 1,342 men 777 women) with a clinically indicated exercise test bicycle ergometer. TWA (time domain-modified moving average method) was analyzed from precordial leads, results were grouped in increments 10 microV. Hazard ratios...
Background. Several traditional cardiovascular risk factors assessed in the middle-aged are associated with of dementia, but they known to lose much their prognostic value when measured elderly. The aim study was compare B-type natriuretic peptide (BNP) previously markers for dementia association cognitive decline and during a follow-up.Methods. A total 464 subjects free aged 75 years or more were examined followed up 5 prospective population-based stratified cohort study. clinical variables...
To assess the prevalence of coronary heart disease (CHD) and chronic hypertension among patients with rheumatoid arthritis (RA) at time diagnosis, in comparison age-specific sex-specific non-RA subjects. Furthermore, impacts age onset RA, as well gender presence factor (RF) on risk these comorbidities, were evaluated.A cohort 7209 RA diagnosed between January 2004 December 2007 was identified, based a Finnish nationwide register special reimbursements for medication costs. The CHD antedating...
Abstract Background The purpose of the Finnish Cardiovascular Study (FINCAVAS) is to construct a risk profile – using genetic, haemodynamic and electrocardiographic (ECG) markers individuals at high cardiovascular diseases, events deaths. Methods design All patients scheduled for an exercise stress test Tampere University Hospital willing participate have been will be recruited between October 2001 December 2007. final number participants estimated reach 5,000. Technically successful data on...
Background A longer heart-rate corrected QT interval (QTc) is associated with increased risk of ventricular arrhythmias. Women have resting QTc and are more likely than men to develop drug-induced prolongation. Recent studies shown association between a common variant (rs10494366) the NOS1 regulator, NOS1AP. We investigated rs10494366 in NOS1AP QTc, assessed gender-specific associations during rest after exercise. Methods SNP 919 women 918 from 504 representative families UK GRAPHIC study,...