A5001951206- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Gout, Hyperuricemia, Uric Acid
- Autoimmune and Inflammatory Disorders Research
- Alcohol Consumption and Health Effects
- Spondyloarthritis Studies and Treatments
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Hepatitis C virus research
- Cardiac Arrhythmias and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Bone and Joint Diseases
- Adolescent and Pediatric Healthcare
- Vasculitis and related conditions
- Chronic Disease Management Strategies
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Inflammasome and immune disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Case Reports on Hematomas
Päijät-Hämeen Keskussairaala
2012-2025
University of Helsinki
2012-2025
Helsinki University Hospital
2022-2025
Institute for Molecular Medicine Finland
2025
Faculty (United Kingdom)
2024
Finland University
2024
Diakonhjemmet Hospital
2021-2022
Center for Rheumatology
2021
Abstract Objectives To explore mortality and causes of death among Norwegian patients with RA, PsA axial spondyloarthritis (axSpA) compared the general population by conducting a nationwide registry-based cohort study. Methods Patients axSpA were identified from Patient Registry based on ICD-10 codes between 2008 2017. Using age as time variable, all-cause cause-specific estimated 2010 2017 Kaplan–Meier estimator cumulative incidence competing risk method, respectively. Sex-, education...
Female sex has previously been associated with poorer outcomes after myocardial infarction (MI), although evidence is scarce among young patients. We studied differences in cardiovascular MI patients <55 years old.Consecutive (18-54 years) all-comer out-of-hospital admitted to 20 Finnish hospitals (n = 8934, 17.3% women) 2004-2014 were by synergizing national registries. Differences between the sexes balanced inverse probability weighting. The median follow-up period was 9.1 (max 14.8...
To assess the prevalence of coronary heart disease (CHD) and chronic hypertension among patients with rheumatoid arthritis (RA) at time diagnosis, in comparison age-specific sex-specific non-RA subjects. Furthermore, impacts age onset RA, as well gender presence factor (RF) on risk these comorbidities, were evaluated.A cohort 7209 RA diagnosed between January 2004 December 2007 was identified, based a Finnish nationwide register special reimbursements for medication costs. The CHD antedating...
To elucidate the risk and temporal relationship of cardiovascular (CV) comorbidities in rheumatic diseases. Patients FinnGen study diagnosed between 2000-2014 with seropositive (n=2368) or seronegative (n=916) rheumatoid arthritis (RA), ankylosing spondylitis (AS, n=715), psoriatic (PsA, n=923), systemic lupus erythematosus (SLE, n=190), primary Sjogren's syndrome (pSS, n=412) gout (n=2034) were identified from healthcare registries. Each patient was matched based on age, sex, birth region...
To estimate the prevalence of psoriatic arthritis (PsA), axial spondyloarthritis (axSpA) and rheumatoid (RA) use biologic agents in these diseases Norway.From Norwegian Patient Registry (NPR), we identified as PsA, axSpA RA patients ≥18 years those with ≥2 recorded episodes diagnostic coding for index disease (L40.5, M07.0-M07.3 PsA; M45, M46.0, M46.1, M46.8 M46.9 axSpA; M05-M06 RA). We calculated point per 1st January 2017 adult population (age ≥18). Dispensed disease-modifying...
To establish the prevalence of hyperuricaemia in an elderly Finnish cohort and to assess its association with comorbidities mortality.Prospective study.Good Ageing Lahti Region study, Finland 2002-2012 (mortality data analysed until 2018).2673 participants (mean age 64 years; 47% men).Prevalence study population was detected. Associations between mortality were assessed using multivariable adjusted Cox proportional hazards models.Data from a prospective, population-based people (52-76 years)...
Rheumatic diseases may impair reproductive success and pregnancy outcomes, but systematic evaluations across are lacking. We conducted a nationwide cohort study to examine the impact of rheumatic on health measures, comparing impacts with those other immune-mediated (IMDs). Out all 5 339 804 Finnish citizens, individuals born 1964-1984 diagnosed any 19 IMDs before age 30 (women) or 35 (men) were matched 20 controls by birth year, sex, education. used data from registers such as and, for...
Objectives We assessed the positive predictive value (PPV) of 17 myositis antibodies for having a diagnosis and other myositis-spectrum conditions (interstitial lung disease (ILD), connective tissue diseases (CTD), malignancy) evaluated impact semiquantitative classification antibody overlap on PPVs. Materials methods retrospectively identified 1068 individuals ≥18 years who tested ≥1 in EUROLINE line blot assay or anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) an ELISA-based test...
Hypertension and atrial fibrillation (AF) are major treatable risk factors for ischemic stroke transient attack (TIA). However, most of the patients with an or TIA fail to reach desired blood pressure (BP) control AF remains underdiagnosed standard ECG monitoring. The aim CARDIOSTROKE study is (1) test effect 3-week non-invasive monitoring combined (2) self-monitoring BP (3) patient-controlled titration antihypertensives over 12 months in recent non-cardioembolic TIA. investigator-initiated,...
Background: Glucose metabolism disorders are major contributors to morbidity and mortality. Elevated serum uric acid (SUA) is closely linked the cardiometabolic consequences of glucose disorders, various other comorbidities, In this study, we explore relationship between SUA fasting plasma (FPG), insulin levels, resistance in an older Finnish adult cohort. Methods: We used data from GOAL (GOod Ageing Lahti region) study—a prospective, population-based study individuals aged 52–76 years. A...
Abstract Objectives To study the annual incidence, diagnostic methods used and clinical presentation of giant cell arteritis (GCA) over time in Finland. Methods Newly diagnosed GCA patients during 2010–2020 were retrospectively identified from four healthcare districts Medical records reviewed, data on methods, phenotype (cranial vs.s large vessel (LV)-GCA) analysed. Results We 602 newly patients. The incidence was 9.0 (95% CI 8.3 to 9.7) cases per 100 000 persons ≥ 50 years age...
Background: Hyperuricemia and steatotic liver disease are both associated with various comorbidities mortality. This study was carried out to the association between hyperuricemia assess impact of etiology on development disease. Methods: Data from a population-based 2635 individuals aged 52–76 years used. defined as serum urate (SU) >410 μmol/L (≈6.9 mg/dL; 75th percentile) fatty index (FLI) ≥80 (75th percentile). We renal if estimated glomerular filtration rate (eGFR) ≤67 mL/min/1.73 m2...
Aim The objective was to examine the prevalence of atherosclerotic cardiovascular disease (ASCVD) and its risk factors among patients with RA diabetes mellitus (RA-DM) without (RAwoDM), evaluate lipid blood pressure (BP) goal attainment in RA-DM RAwoDM primary secondary prevention. Methods cohort derived from Survey Cardiovascular Disease Risk Factors Patients Rheumatoid Arthritis 53 centres/19 countries/3 continents during 2014–2019. We evaluated (CVD) RAwoDM. study population divided into...
Abstract Objective To investigate the long-term outcomes of patients with RA after myocardial infarction (MI). Methods All-comer, real-life MI (n = 1614, mean age 74 years) were retrospectively compared propensity score (1:5) matched without 8070) in a multicentre, nationwide, cohort register study Finland. The impact duration and usage corticosteroids antirheumatic drugs on patients’ also studied. median follow-up was 7.3 years. Results associated an increased 14-year mortality risk [80.4%...
Type 1 diabetes is a risk factor for myocardial infarction (MI). We aimed to evaluate the case fatality in patients with type after MI.
Both hyperuricaemia and chronic kidney disease are known mortality risk factors. This study examined the modifying effect of renal function on hyperuricaemia-associated risk, which is an issue that has not been studied before.