A5005554997- Folate and B Vitamins Research
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Muscle metabolism and nutrition
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Antioxidant Activity and Oxidative Stress
- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Sulfur Compounds in Biology
- Metabolism, Diabetes, and Cancer
- Obesity, Physical Activity, Diet
- Migraine and Headache Studies
- Vitamin C and Antioxidants Research
- Privacy, Security, and Data Protection
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Retinoids in leukemia and cellular processes
- Digitalization, Law, and Regulation
University of Oslo
2007-2025
Metropolitan University
2024
Iowa State University
2001-2022
University of Bergen
1993-2017
New York City Police Department
2016
Saint Louis University Hospital
2010
Norwegian Computing Center
2007
Bispebjerg Hospital
1981-1994
Aarhus University Hospital
1962-1991
Hvidovre Hospital
1981
Of 330 patients given lithium for recurrent manic-depressive disorder 12 developed goitre after treatment periods of five months to two years. All the remained clinically euthyroid. Pressure symptoms necessitated subtotal thyroidectomy in patients. In 9 out 10 with goitre, and seven without study radioactive iodine showed abnormal findings metabolism. Discontinuance led disappearance goitres, while thyroid metabolism returned normal. Thyroxine or desiccated produced shrinkage gland spite...
Abstract Background Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, composition, resting rate, gene expression profiles white adipose tissue (WAT), and an extensive blood biomarker profile humans with overweight or obesity. Methods N = 59 participants obesity (73% women) were randomized stratified by sex to 8-week plant-based intervention low (~ 2 g /day, SAAR) high 5.6 control group)...
ABSTRACT Five unconformity-bounded sequences have been documented within a 1300 m thick succession of predominantly fluvial Upper Cretaceous and Lower Tertiary deposits in the Price Canyon area westernmost part Book Cliffs, east-central Utah, U.S.A. This experienced major tectonically induced changes paleogeography during deposition. The earliest study were formed relatively simple foreland basin setting front Sevier Orogenic Belt, contain more marine influence than previously recorded....
• Regional cerebral blood flow (rCBF) was measured in seven patients during classic migraine attacks. Single photon emission computed tomography performed soon after hospital admission, and three to eight hours, 20 24 one week later the onset of symptoms. Initially reduced rCBF persisting up hours observed hemisphere appropriate focal neurologic deficit; hyperperfusion noted same region these patients. At normal four patients, hyperemia persisted two patient not restudied. The area interest...
Serum concentrations of T4, T3, rT3, free and TSH were determined in four groups adult subjects: group A, 27 healthy young volunteers (aged 18–29 yr); B, 24 carefully selected elderly subjects 70–90 C, 41 living at a municipal nursing home for the D, 35 hospitalized patients yr). Identical levels iodothyronines serum found subjects. Moderate severe disease induced alterations iodothyronine comparable to those reported earlier. T3 low rT3 high C D subjects; T4 was elevated while low. lower...
Excess levels of serum acylcarnitines, which are intermediate products in metabolism, have been observed metabolic diseases such as type 2 diabetes mellitus. However, it is not known whether acylcarnitines may prospectively predict risk cardiovascular death or acute myocardial infarction patients with stable angina pectoris.This study included 4164 (median age, 62 years; 72% men). Baseline acetyl-, octanoyl-, palmitoyl-, propionyl-, and (iso)valerylcarnitine were measured using liquid...
Abstract Background Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential humans, we evaluated effects dietary on cardiometabolic risk factors, plasma urinary amino acid profile, serum fibroblast growth factor 21 (FGF21), subcutaneous adipose tissue gene expression women with overweight obesity double-blind randomized controlled pilot study. Methods Twenty or were allocated to diet low...
Abstract Aims/hypothesis Obesity and insulin resistance may be associated with elevated plasma concentration of branched-chain amino acids (BCAAs) impaired BCAA metabolism. However, it is unknown whether the insulin-sensitising effect long-term exercise can explained by concomitant change in BCAAs their Methods We included 26 sedentary overweight normal-weight middle-aged men from MyoGlu clinical trial, or without dysglycaemia, for 12 weeks supervised intensive intervention, including two...
1. Regional cerebral blood flow (rCBF) was measured during rest and listening to simple words. The xenon-133 intracarotid technique used results were obtained from 254 regions of seven right hemispheres left hemispheres. measurements performed just after carotid angiography, carried out exclude space occupying lesions. In all subjects the angiogram normal. All handed. 2. Mean hemispheric both increased 10% resting measurement task. This increase due in part activation entire hemisphere....
Plasma sulphur-containing amino acids and related metabolites are associated with insulin sensitivity, although the mechanisms unclear. We examined effect of exercise on this relationship. Dysglycemic (n = 13) normoglycemic men underwent 45 min cycling before after 12 weeks intervention. performed hyperinsulinemic euglycemic clamp, mRNA-sequencing skeletal muscle adipose tissue biopsies, targeted profiling plasma by LC-MS/MS. Insulin sensitivity increased similarly in dysglycemic exercise,...
Abstract Extracellular vesicles induced by exercise have emerged as potential mediators of tissue crosstalk. and their cargo miRNAs been linked to dysglycemia obesity in animal models, but role humans is unclear. Aim The aim the study was characterize miRNA content plasma extracellular vesicle isolates after acute long‐term associations between miRNAs, mRNA expression skeletal muscle adipose tissue, cardiometabolic risk factors. Methods Sedentary men with or without overweight underwent an...
Physical activity is associated with beneficial adaptations in human and rodent metabolism. We studied over 50 complex traits before after exercise intervention middle-aged men a panel of 100 diverse strains female mice. Candidate gene analyses three brain regions, muscle, liver, heart, adipose tissue mice indicate genetic drivers clinically relevant traits, including volitional volume, muscle metabolism, adiposity, hepatic lipids. Although ∼33% genes differentially expressed skeletal...
Dietary and plasma total cysteine (tCys) have been associated with adiposity, possibly through interaction stearoyl⁻CoA desaturase (SCD), which is an enzyme that involved in fatty acid energy metabolism. We evaluated the effect of a dietary intervention low methionine high polyunsaturated acids (PUFAs) on urinary sulfur amino SCD activity indices. Fourteen normal-weight healthy subjects were randomized to seven-day diet PUFAs (Cys/Metlow + PUFA), or saturated (SFA), cysteine, (Cys/Methigh...
Background Various altitude training regimes, systematically used to improve oxygen carrying capacity and sports performance, have been associated with increased oxidative stress inflammation. We investigated whether intake of common antioxidant-rich foods attenuates these processes. Methods In a randomized controlled trial, 31 elite endurance athletes (23 ± 5 years), ingested (n = 16), (> doubling their usual intake), or eucaloric control 15) during 3-week camp (2320 m). Fasting blood urine...
The aim was to investigate if fatty acid profile and estimated desaturase activities; stearoyl CoA-desaturase (SCD), delta-5-desaturase delta-6-desaturase (D5D; D6D), differ between individuals with metabolically healthy (MH) unhealthy (MU) phenotypes. We also explored these associations according BMI categories.Men women at moderately elevated risk of cardiovascular disease were included in this cross-sectional study (n = 321). If subjects met ≥4 out 5 criteria (elevated triglycerides,...
Abstract Background Elevated plasma methylmalonic acid (MMA) is reported in patients with established coronary heart disease (CHD) and considered a marker of vitamin B12 deficiency. Moreover, MMA‐dependent reactions have been linked to alterations mitochondrial energy metabolism oxidative stress, key features the pathophysiology cardiovascular diseases (CVDs). Objectives We examined whether MMA prospectively predicted long‐term risk acute myocardial infarction (AMI) mortality. Methods...
In eight patients carotid angiography was required for evaluation of transient neurological attacks. Cerebral blood flow results, and clinical observations subsequently suggested the diagnosis migraine. We measured plasma concentrations substance P(SP), neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP) vasoactive intestinal (VIP) in repeated samples obtained from artery internal jugular vein conjunction with cerebral followed by 4 to 6 recordings regional (rCBF) intracarotid...
Cystathionine β-synthase (CBS)-deficient homocystinuria (HCU) is an inherited disorder of sulfur amino acid metabolism with varying severity and organ complications, a limited knowledge about underlying pathophysiological processes. Here we aimed at getting in-depth insight into disease mechanisms using transgenic mouse model HCU (I278T). We assessed metabolic, proteomic sphingolipidomic changes, mitochondrial function in tissues body fluids I278T mice WT controls. Furthermore, evaluated the...
Aging is associated with dysregulated methionine metabolism and increased levels of enzymes in the tyrosine degradation pathway (TDP). To investigate efficacy targeting either or TDP for healthspan improvement advanced age, we initiated dietary MetR inhibition 18-month-old C57BL/6J mice. significantly improved neuromuscular function, metabolic health, lung frailty. In addition, confirmed function from 5XFAD mice, whose weight was not affected by MetR. We did observe benefits inhibition....
Abstract Background Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if dietary SAA can reduce body weight improve resting energy expenditure (REE) parameters related to Method/design Men women (calculated sample size = 60), aged 18–45 years, with mass index of 27–35 kg/m 2 be included a double-blind 8-week...