A5031436708- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Peripheral Artery Disease Management
- S100 Proteins and Annexins
- Venous Thromboembolism Diagnosis and Management
- Peripheral Neuropathies and Disorders
- Stroke Rehabilitation and Recovery
- Retinal and Optic Conditions
- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Sepsis Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Renal and Vascular Pathologies
- Blood properties and coagulation
- Inflammation biomarkers and pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Complications and Syndromes
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 diagnosis using AI
- Intensive Care Unit Cognitive Disorders
Unidades Centrales Científico-Técnicas
2023-2024
Universidad de Navarra
2020-2024
Biogipuzkoa Health Research Institute
2022-2024
Universidad de Deusto
2024
Navarre Institute of Health Research
2020-2024
Hospital Universitario Miguel Servet
2023
Complejo Hospitalario de Navarra
2019-2023
Instituto de Salud Carlos III
2023
Instituto de Investigación Sanitaria Aragón
2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2023
Spain has been one of the countries heavily stricken by COVID-19. But this epidemic not affected all regions equally. We analyzed impact COVID-19 pandemic on hospital stroke admissions and in-hospital mortality in tertiary referral hospitals from North-West Spain.Spanish multicenter retrospective observational study based data NORDICTUS network. recorded number patients admitted for ischemic between 30 December 2019 3 May 2020, IVT EVT procedures, mortality.In period, 2737 were with stroke....
Matrix metalloproteinases (MMPs) are proteolytic zinc-endopeptidases regulated by tissue Inhibitors of matrix (TIMPs). We evaluated the potential MMPs and TIMPs as clinical tools for Intracranial Haemorrhage (ICH). Spontaneous non-traumatic ICH patients were recruited from two hospitals: Complejo Hospitalario de Navarra (CHN = 29) Vall d´Hebron (VdH 76). Plasmatic levels MMP-1, -2, -7, -9, -10 TIMP-1 their relationship with clinical, radiological functional variables evaluated. further...
Abstract Background Inflammatory response plays an important role in many processes related to acute ischemic stroke (AIS). Calprotectin (S100A8/S100A9), released by monocytes and neutrophils, is a key protein the regulation of inflammation thrombosis. The purpose this study evaluate association circulating calprotectin with other inflammatory biomarkers AIS prognosis, as well content thrombi. Methods Among 748 patients treated at comprehensive center between 2015 2017, 413 confirmed injury...
Spain has been one of the countries more heavily stricken by SARS-CoV-2, which had huge implications for stroke care. The aim was to analyse impact COVID-19 epidemic outbreak on reperfusion therapies acute ischaemic in northwest Spain.This a Spanish multicentre retrospective observational study based data from tertiary hospitals NORDICTUS network. All patients receiving therapy between 30 December 2019 and 3 May 2020 were recorded, their baseline, clinical radiological characteristics,...
Background: Actual clinical management of ischemic stroke (IS) is based on restoring cerebral blood flow using tissue plasminogen activator (tPA) and/or endovascular treatment (EVT). Mechanical thrombectomy has permitted the analysis thrombus structural and cellular classic components. Nevertheless, histological assessment hemostatic parameters such as thrombin-activatable fibrinolysis inhibitor (TAFI) matrix metalloproteinase 10 (MMP-10) remains unknown, although their presence could...
Background-Active coagulation factor XIII (FXIIIa) catalysing crosslinking of fibrin and other hemostatic factors, plays a key role in clot stability lysis.Objective-To evaluate the effect FXIII inhibition mouse model ischemic stroke (IS), FXIIIa formation lysis IS patients.Methods-FeCl3 murine was performed before after administration inhibitor (FXIIIinh).Thromboelastometry human mice blood used to thrombus stiffness with FXIIIinh.FXIIIa-dependent fibrinolytic drugs (tPA TNK) were studied...
La pandemia ocasionada por la aparición del SARS-CoV-2, ha transformado práctica médica, y alterado gravemente formación de los médicos residentes a nivel mundial. Desde Sociedad Española Neurología (SEN) se querido conocer el grado repercusión que COVID-19 tenido en ámbito formativo entre neurología. Se realizó un estudio descriptivo transversal mediante envío una encuesta email todos neurología miembros dicha sociedad. incluyeron preguntas relativas aspectos demográficos, actividad...
La obtención del material trombótico en el ictus isquémico desde la generalización de trombectomía mecánica ha permitido un estudio exhaustivo mismo y los posibles mecanismos fisiopatológicos subyacentes a su formación. Los trombóticos implicados diferentes lechos vasculares no difieren exceso, condicionando una heterogeneidad importante que dificultado identificación patrones asociados al origen o etiología ictus. Se observado, sin embargo, mayor influencia factores como tiempo desarrollo...
Accurate etiologic diagnosis provides an appropriate secondary prevention and better prognosis in ischemic stroke (IS) patients; still, 45% of IS are cryptogenic, urging us to enhance diagnostic precision. We have studied the transcriptomic content plasma extracellular vesicles (EVs) (n = 21) identify potential biomarkers etiologies. The proteins encoded by selected genes were measured sera patients 114) hypertensive with 78) without atrial fibrillation (AF) 20). IGFBP-2, most promising...
The COVID19 pandemic collapsed intensive care units (ICUs) all around the world, conditioning systems of (SOC) for other critical conditions such as severe ischemic stroke requiring endovascular treatment (EVT). Our aim was to evaluate impact an adaptive Stroke Unit (SU) based SOC on functional outcomes, with goal avoiding both general anesthesia (GA) and ICU admission in patients treated EVT.We performed observational study comparing data from our traditional ICU-GA SU-Conscious Sedation...
Intracranial hemorrhage (ICH) is one of the major devastating complications anticoagulation. Matrix metalloproteinase (MMP) inhibition has been proposed as a novel pharmacological approach for ICH treatment. We evaluated effects CM-352 (MMP-fibrinolysis inhibitor) in an experimental model associated with oral anticoagulants compared clinically used prothrombin complex concentrate (PCC). was induced by collagenase injection into striatum wild type (C57BL/6J) anticoagulated mice (warfarin or...
Este estudio busca identificar el potencial pronóstico de los parámetros la analítica urgente en pacientes con ictus isquémico. Se recogió prospectivamente a 592 evento isquémico cerebral confirmado por neuroimagen, atendidos una unidad entre 2015 y 2018. registraron extraídos se calculó ratio neutrófilos/linfocitos neutrófilos/plaquetas (neutrófilos × 1.000/plaquetas). evaluó mediante modelos regresión logística su asociación funcional, evaluado escala Rankin modificada, desarrollo...
To study the response times of stroke code assistance by care units 061 ARAGON, analyzing factors involved and their relationship with availability to fibrinolytic treatment in hyperacute phase.Transversal descriptive on outpatient from registry cases attended ARAGON health patients during period 2010-2016.A total 1743 were (54.6% males), a mean age 72.83 ± 13.1 years. There was higher number strokes 2015 2016 (372 366 respectively), compared average 201 per year rest 27,2% treated between...