A5063381975- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Psoriasis: Treatment and Pathogenesis
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Acne and Rosacea Treatments and Effects
- Nonmelanoma Skin Cancer Studies
- Infectious Diseases and Mycology
- Urticaria and Related Conditions
- Nail Diseases and Treatments
- Fungal Infections and Studies
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- melanin and skin pigmentation
- Immunotherapy and Immune Responses
- Mast cells and histamine
- Cancer and Skin Lesions
- T-cell and B-cell Immunology
- Estrogen and related hormone effects
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Skin Protection and Aging
- Angiogenesis and VEGF in Cancer
- Nutrition, Genetics, and Disease
Gdańsk Medical University
2015-2024
University Clinical Centre
2024
University of Gdańsk
2014
Background and Objectives: Psoriasis is a common, chronic, immune-mediated inflammatory skin disease recognized to lead wide range of comorbid disorders, mainly obesity. The study aimed evaluate the problem overweightness obesity among psoriasis patients in context their prevalence influence on course. Materials Methods: group encompassed 147 adult with plaque psoriasis. Results: prevalences (39.46%) (37.41%) demonstrated showed strong predisposition psoriatic for abnormal body mass. vast...
There is evidence that the concomitance of psoriasis and obesity may originate from interplay between multiple genetic pathways involve gene–gene interactions. The aim this study was to compare background related among psoriatic patients versus healthy controls by means a Genome-Wide Association Study (GWAS). A total 972 5878 donors were enrolled in study. DNA samples genotyped for over 500,000 single nucleotide polymorphisms (SNPs) using Infinium CoreExome BeadChips (Illumina, San Diego,...
Psoriasis (PsO) is a chronic, immune-mediated, inflammatory skin disease associated in most cases with pruritus. Chemokines seem to play significant role PsO pathogenesis. The aim of the study was analyse serum concentrations CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL17/TARC, CCL18/PARC, CCL22/MDC and CXCL8/IL-8, their correlation severity pruritus intensity. included 60 patients 40 healthy volunteers. Serum six (CCL2/MCP-1, CCL18/PARC CCL22/MDC) out eight analysed chemokines...
Tumour necrosis factor (TNF)-alpha is considered to be an important mediator in the pathogenesis of psoriasis. Increased levels and activity this cytokine have been observed blood skin patients with As certain allelic variants TNF-alpha gene are associated increased or decreased production TNF-alpha, disturbed balance may under genetic control.To investigate potential association promoter alleles within subtypes psoriasis compared healthy controls a northern Polish population.We analysed 166...
The epidemiology of psoriasis has not been widely assessed in Polish population so far. This study aimed to investigate epidemiological situation by evaluating disease course and severity, management, comorbidities, environmental factors, knowledge about this disorder among psoriatic patients Poland. A cross-sectional cohort population-based enrolled 1080 1200 controls. mean age onset was 27.6 years; 78.24% had type I psoriasis. Positive family history reported 44.81% patients, whereas itch...
Mastocytosis is a heterogenous disease involving mast cells (MC) and their progenitors. Cutaneous systemic variants of the have been reported. In contrast to cutaneous mastocytosis (CM), patients with (SM) are at risk develop progression or nonMC-lineage haematopoietic neoplasm. Little known, however, about factors predisposing for development SM. One factor may be cytokine regulation MC progenitors.We examined role interleukin-13 (IL-13) promoter gene polymorphism -1112C/T, known associated...
Data on interleukin-31 (IL-31) involvement in the patho-genesis of mastocytosis, and its impact pruritus development disease, are limited. The aim this study was to analyse distinct IL-31 gene polymorphisms 127 patients (age 0.5-76 years) with mastocytosis their correlation clinical presentation, serum levels. In frequency IVS2+12AA genotype IVS2+12A allele higher than control subjects they were linked an increased risk mastocytosis. adult patients, but not children, -2057AA also associated...
Recent studies have indicated a key role of the impaired suppressive capacity regulatory T cells (Tregs) in psoriasis (PsO) pathogenesis. However, genetic background Treg dysfunctions remains unknown. The aim this study was to evaluate association PsO development with selected single nucleotide polymorphisms (SNPs) genes which protein products play significant regulation differentiation and function Tregs. There were three groups our research each consisted different unrelated patients...
Interleukin 16 (IL-16) has been described as a significant cytokine involved in the recruitment of CD4+ cells during inflammation; however, its potential role psoriasis not defined. Our aim was to investigate IL-16 serum levels and mRNA skin expression patients correlation with disease severity for CD4. Moreover, localization assessed -295 T/C polymorphism analyzed. For this exploratory, observational, cross-sectional study, 97 unrelated chronic plaque type 104 healthy controls were...
Abstract Background Neovascularization plays an important role in pathogenesis of psoriasis and vascular endothelial growth factor (VEGF) seems to be the main angiogenic involved this disease. Published studies which analysed VEGF gene polymorphism were limited they received controversial results. Objective The aim our study was evaluate association between −1154 G/A, −460 T/C +405 G/C polymorphisms susceptibility determine whether genetic variation influence levels protein expression....
The role of a number inherited, acquired and environmental factors has been identified to increase the risk onychomycosis. literature data on psoriasis as factor are contradictory. potential relationship between these pathologies is very important it influences patient management.To evaluate frequency onychomycosis etiological in patients with compared controls.The studied group (n = 2427) included 2325 nail abnormalities raising clinical suspicion (with no history psoriasis) 102 psoriatic...
The pathophysiology of atopic dermatitis (AD) is complex, multifactorial, and not fully understood. Genes encoding collagens, the most abundant proteins in extracellular matrix (ECM), may play a potential role pathogenesis AD. Our study aimed to estimate associations between
This study aimed to comprehensively analyze the problem of overweight and obesity among psoriatic patients by investigating influence body mass composition, anhedonia depression, environmental factors FTO gene polymorphisms. Methods: The enrolled 30 or obese adult with chronic plaque psoriasis volunteers (northern Poland region, Caucasian population). Mood disorders, composition using bioelectrical impedance analysis (BIA) polymorphisms (rs9939609, rs1558902) tetra-primer amplification...
Abstract Background Severe pruritus is one of the cardinal symptoms atopic dermatitis ( AD ). Recently, interleukin IL )‐31 cytokine has been implicated in induction and maintenance severe chronic skin inflammation several pruritic diseases, including . Objective We aimed to investigate association ‐31 gene haplotypes with severity , as well their correlation serum levels. Methods A total 127 patients 96 healthy controls were analyzed for polymorphic variants using an amplification...
Materials & methods: Polymorphic variants of IL-2 gene (-330 T/G and +166 G/T), IL-10 (-1082 G/A -819 C/T) serum cytokines concentrations in the group 179 patients with BCC 173 controls were analyzed. Results: The presence -330 GG genotype or -1082 GA increased risk (OR 3.68) 3.07). AA 9.63). levels significantly lower (p < 0.0004) while concentration was higher 0.00001). Conclusion: polymorphisms genes may contribute to susceptibility influence clinical course polish population.
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Nedoszytko B, Olszewska Roszkiewicz J, et al. The role of polymorphism interleukin 2, 10, 13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis. Advances Dermatology Allergology/Postępy Dermatologii i Alergologii. 2016;33(6):429-434. doi:10.5114/ada.2016.63881. APA Nedoszytko, B., Olszewska, Roszkiewicz, J., Glen, Zabłotna, M., & Ługowska-Umer, H. (2016). Alergologii, 33(6), 429-434....
IL-6/STAT3 signaling pathway has been suggested to play a role in CTCL pathogenesis. Polymorphisms STAT3 pathway-related genes might be risk factor for CTCL. However, the exact of inherited gene polymorphisms IL-6 and pathogenesis is still not fully understood. The aim was examine whether cytokine are associated with susceptibility, stage disease pruritus intensity. We compared serum level frequency selected single nucleotide 106 198 control group using polymerase chain reaction...
Basal cell carcinoma (BCC) environment consists of stromal and inflammatory cells which produce variety cytokines, chemokines growth factors that may affect tumor behavior. One the cytokines suggested to be involved in pathogenesis BCC is IL-6, upstream element IL-6/JAK/STAT3 pathway. The correlation between polymorphisms genes related this pathway cancer risk/prognosis have been previously investigated several neoplasia, but available data concerning are scarce. In present study, rs1800795...
Polymorphic variants of the genes encoding monocyte chemoattractant protein-1 (MCP-1/CCL2) and regulated upon activation normal T-cell expressed secreted (RANTES/CCL5) their protein serum levels have not been widely explored in psoriasis.To clarify effect MCP-1 (-2518 A/G) RANTES (-403 G/A) promoter gene polymorphisms on risk clinical manifestation psoriasis.We enrolled 160 unrelated patients with psoriasis vulgaris healthy, unrelated, age- sex-matched volunteers. The were analysed using...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Zabłotna M, Sobjanek Purzycka-Bohdan D, Szczerkowska-Dobosz A, Nedoszytko B, Nowicki RJ. The significance of Toll-like receptor (TLR) 2 and 9 gene polymorphisms in psoriasis. Advances Dermatology Allergology/Postępy Dermatologii i Alergologii. 2017;34(1):85-86. doi:10.5114/ada.2017.65628. APA Zabłotna, M., Sobjanek, Purzycka-Bohdan, D., Szczerkowska-Dobosz, A., Nedoszytko, B., & Nowicki, R. J. (2017)....
Interleukin-31 (IL-31) impact on the development and clinical presentation of psoriasis as well pruritus has not been widely investigated so far.To analyse IL-31 -1066G/A -2057G/A promoter gene polymorphisms serum level their correlation with severity in population northern Poland.The study included 300 patients 186 healthy volunteers. The were analysed using amplified refractory mutation system - polymerase chain reaction (ARMS-PCR) method. Serum levels measured enzyme-linked immunosorbent...