A5039169060- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Effects of Radiation Exposure
- Medical Imaging Techniques and Applications
- Radiation Effects and Dosimetry
- Microfluidic and Capillary Electrophoresis Applications
- DNA Repair Mechanisms
- Nonmelanoma Skin Cancer Studies
- Head and Neck Cancer Studies
- Ultrasound and Hyperthermia Applications
- Engineering Applied Research
- Particle accelerators and beam dynamics
Helmholtz Zentrum München
2019-2024
Klinikum rechts der Isar
2019-2020
Technical University of Munich
2019-2020
Abstract FLASH-radiotherapy may provide significant sparing of healthy tissue through ultra-high dose rates in protons, electrons, and x-rays while maintaining the tumor control. Key factors for FLASH effect might be oxygen depletion, immune system, irradiated blood volume, but none could fully confirmed yet. Therefore, further investigations are necessary. We investigated protective (tissue sparing) proton treatment using an in-vivo mouse ear model. The right ears Balb/c mice were with 20...
The use of different scoring systems for radiation-induced toxicity limits comparability between studies. We examined dose-dependent tissue alterations following hypofractionated X-ray irradiation and evaluated their as criteria. Four dose fractions (0, 5, 10, 20, 30 Gy/fraction) were applied daily to ear pinnae. Acute effects (ear thickness, erythema, desquamation) monitored 92 days after fraction 1. Late (chronic inflammation, fibrosis) the presence transforming growth factor beta 1...
Purpose X‐ray microbeam radiation therapy is a preclinical concept for tumor treatment promising tissue sparing and enhanced control. With its spatially separated, periodic micrometer‐sized pattern, this method requires high dose rate collimated beam typically available at large synchrotron facilities. To treat small animals with microbeams in laboratory‐sized environment, we developed dedicated irradiation system the Munich Compact Light Source (MuCLS). Methods A specially made collimation...
High-linear energy transfer (LET) radiation, such as heavy ions is associated with a higher relative biological effectiveness (RBE) than low-LET photons. Irradiation low- and high-LET particles differ in the interaction cellular matter therefore spatial dose distribution. When single particle interacts matter, it results doses of up to thousands gray (Gy) locally concentrated around ion trajectory, whereas mean averaged over target, cell nucleus only range Gy. DNA damage accumulates this...