A5008838011- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Myasthenia Gravis and Thymoma
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Pituitary Gland Disorders and Treatments
- Ear and Head Tumors
- Cardiac tumors and thrombi
- HER2/EGFR in Cancer Research
- Meningioma and schwannoma management
- Metastasis and carcinoma case studies
- Occupational and environmental lung diseases
- Gastric Cancer Management and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Sarcoma Diagnosis and Treatment
- Geotechnical Engineering and Underground Structures
- Soft tissue tumors and treatment
- Testicular diseases and treatments
Nagoya City University
2008-2024
Mizuho (Japan)
2005-2022
Nagoya Medical Center
2022
First Affiliated Hospital of Guangzhou Medical University
2018
Guangzhou Medical University
2018
Seirei Mikatabara General Hospital
2008-2012
Higashi Osaka City General Hospital
2007
Hiroshima Kyoritsu Hospital
2000-2001
Much evidence has accumulated that the epidermal growth factor receptor (EGFR) and its family members are strongly implicated in development progression of lung cancers. Somatic mutations EGFR gene were found about 25-40% Japanese cancer patients. More recently, erbB2 4% European-derived We have investigated mutation status 95 surgically treated nonsmall cell (NSCLC) cases from Nagoya City University Hospital. Seventy-five adenocarcinoma included. The presence or absence ernB2 kinase domains...
Background: The presence of epidermal growth factor receptor (EGFR) mutations in gefitinib-naive lung cancer patients has been reported to be higher females, non-smokers, Japanese, and adenocarcinoma patients, especially bronchioloalveolar carcinoma (BAC). To further investigate the prevalence EGFR relation pathological factors, we evaluated series Japanese who had never treated with gefitinib.
Background: Epidermal growth factor receptor (EGFR) gene mutations have been reported to correlate with the sensitivity tyrosine kinase inhibitor treatment for advanced lung cancers. Since several reports shown that invasive thymoma overexpress EGFR protein, we examined expression and mutation statuses in thymic carcinoma tissues. Methods:EGFR from 99 epithelial tumor samples were evaluated by a rapid sensitive TaqMan assay using Applied Biosysytems 7500 real-time PCR system. Probes designed...
Glucocorticoid was used in thymomas. The purpose of the study to evaluate efficacy intravenous high-dose glucocorticoid (steroid pulse) therapy patients with previously untreated advanced thymoma. Causes were also sought for a possible underlying mechanism effect steroid on thymoma.Seventeen invasive thymoma who had not received previous chemotherapy or radiation enrolled study. All cases treated 2 courses before surgery. Tumor response assessed by computed tomography (CT) scan 1 week after...
Currently, four immunohistochemical assays are registered with the US Food and Drug Administration to detect expression of PD-L1. We investigated PD-L1 in thymic carcinomas using these diagnostic assays. The cases 53 patients were reviewed their specimens subjected different antibodies (SP142, SP263, 22C3, 28-8). tumor cells (TCs) immune (ICs) was evaluated. In TCs, showed similar scores each case. Histopathologically, high TC observed squamous cell (SqCCs). Meanwhile, there no significant...
While segmentectomy is considered a viable option for small peripheral non-small-cell lung cancer, its efficacy central lesions remains uncertain. This study aimed to assess the oncological outcomes of compared ones.
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 pathway are expected to be a novel therapy for combating future increases in numbers of malignant pleural mesothelioma (MPM) patients. However, PD-L1 expression, which is predictor response ICIs, unclear MPM. We studied expression using four immunohistochemical assays (SP142, SP263, 28-8 and 22C3) 32 MPM The tumor cells immune was evaluated clarify rate concordance among positivity 53.1% SP142, 28.1% 28-8, 56.3% 22C3. Nine cases...
Pure red cell aplasia (PRCA) associated with thymoma is relatively rare, and relevant reports are limited. We investigated the clinical features outcomes of PRCA in this study.A retrospective review all patients who underwent surgical resection from April 1, 2004, to December 31, 2015, was performed.We experienced eight among 146 thymoma. Extended thymectomy (n=4) were performed for Regarding WHO classification thymoma, subtypes type B2 or B3 seven patients, stage advanced patients. Complete...
We herein report the usefulness of two types talc pleurodesis for secondary pneumothorax elderly patients with persistent air leak who have severe pulmonary emphysema.We assessed 17 received from April 2013 to March 2017. Thoracoscopic poudrage (TTP) (n=11) was performed in whose general condition thought sufficiently stable tolerate anesthesia. Talc slurry (TSP) (n=6) via a chest tube be insufficiently anesthesia.The median drainage period after 6 days TTP and 12 TSP. Complications...
Background: A gatekeeper T790M mutation is thought to cause resistance epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment. The detection of a 2nd important for planning the next therapy when patients acquire first line EGFR-TKI.