A5078979265- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Empathy and Medical Education
- Contact Dermatitis and Allergies
- Medicine and Dermatology Studies History
- Medical History and Research
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Advancements in Transdermal Drug Delivery
University Hospital Schleswig-Holstein
2023-2025
University of Lübeck
2023-2025
Kiel University
2023
Abstract Background Interleukin (IL)-13 is a key driver of inflammation and barrier dysfunction in atopic dermatitis (AD). While there robust evidence that tralokinumab – monoclonal antibody neutralizes IL-13 reduces clinical disease activity, less known about its effects on function. Objectives To characterize the treatment skin Methods Transepidermal water loss (TEWL), stratum corneum hydration (SCH), natural moisturizing factor content, histopathological characteristics, biomarker...
Abstract Background Atopic dermatitis (AD) patients display an altered skin microbiome which may not only be indicator but also a driver of inflammation. We aimed to investigate associations among AD patients' microbiome, clinical data, and response systemic therapy in the TREATgermany registry. Methods Skin swabs 157 were profiled with 16S rRNA gene amplicon sequencing before after 3 months treatment dupilumab or cyclosporine. For comparison, 16s data from 258 population‐based healthy...
Zusammenfassung Psychosomatische Aspekte in der Dermatologie finden zunehmend bei dermatologischen Therapieansätzen Beachtung und tragen auf psychoimmunologischen Ebene zu einem besseren Verständnis verschiedener dermatologischer Erkrankungen bei. In Universitätshautklinik Kiel wurden im Rahmen von zwei BMBF-geförderten Lehrprojekten ab 2018 Kurse Kleingruppen zum Thema „Psychosomatische Dermatologie“ freiwilliger Basis angeboten evaluiert. Um wichtige Lerninhalte auch einer größeren Zahl...
Atopic dermatitis (AD) is characterised by a skin barrier defect, type 2 immune-mediated inflammation, and microbial dysbiosis [1]. Three-dimensional human equivalents (3DSE) effectively mimic providing stratified grown on dermis-like matrix. These models enable mechanistic AD studies; however, few have incorporated bacteria or immune cells, both of which are essential to fully recapitulate features. In this study, we refined AD-like 3DSEs integrating Staphylococcus aureus (S. aureus) cells...
Several small studies have indicated that daily emollient use from birth might delay, suppress or prevent atopic dermatitis (AD). Two larger trials did not confirm this; however, a recent smaller study protective effect if is used in the first 2 months of life. Further research needed to evaluate on development AD. The current randomly assigned 50 newborns who were at high risk developing AD (1:1) receive general infant skin-care advice (control group), plus with apply least once until 1...
Atopic dermatitis (AD) is the most common paediatric inflammatory skin disease. There are currently no robust biomarkers that could reliably predict its manifestation, and on molecular level, it less well characterized than adult AD.
The organ-specific microbiome plays a crucial role in tissue homeostasis, among other things by inducing regulatory T cells (Treg). This applies also to the skin and this setting short chain fatty acids (SCFA) are relevant. It was demonstrated that topical application of SCFA controls inflammatory response psoriasis-like imiquimod (IMQ)-induced murine inflammation model. Since signal via HCA2, G-protein coupled receptor, HCA2 expression is reduced human lesional psoriatic skin, we studied...