A5061459400- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Fibroblast Growth Factor Research
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Nutritional Studies and Diet
- Diet and metabolism studies
- Neuroblastoma Research and Treatments
- Dietary Effects on Health
- Renal cell carcinoma treatment
- Thyroid and Parathyroid Surgery
Endocrinology Research Center
2018-2025
Ministry of Health of the Russian Federation
2019-2022
<h3>Importance</h3> Large studies investigating long-term outcomes of patients with bilateral pheochromocytomas treated either total or cortical-sparing adrenalectomies are needed to inform clinical management. <h3>Objective</h3> To determine the association vs adrenalectomy pheochromocytoma-specific mortality, burden primary adrenal insufficiency after adrenalectomy, and risk pheochromocytoma recurrence. <h3>Design, Setting, Participants</h3> This cohort study used data from a multicenter...
Ganglioneuromas (GN) are rare benign neoplasms originating from neural crest tissue. These tumors typically asymptomatic and often detected incidentally during diagnostic imaging studies. Although the radiological characteristics of adrenal GNs relatively well-studied, establishing an accurate diagnosis still remains a challenging task. Currently, definitive is established based on morphological examination postoperative material. This publication presents clinical case GN identified in...
Pheochromocytoma is a rare neuroendocrine tumor consisting of chromaffin cells the adrenal medullary layer, special case sympathetic paraganglioma. The classic clinical sign pheochromocytoma sympathoadrenal crisis characterized by attacks significant increase in blood pressure, tachycardia, severe sweating, and vasomotor reactions. This article describes with non-classical onset disease combination nonspecific symptoms no hypertension at disease. patient, 57 years old, presented National...
Pheochromocytoma (PCС) and paraganglioma (PG) are malignant neuroendocrine tumors (NEO) of paraganglionic origin, producing biologically active substances characterized by a variable clinical course. Currently, the main method treatment PCС PG is radical surgical treatment; nevertheless, there life-long risk tumor recurrence as well distant metastases. Here we present case recurrent retroperitoneal incidentally detected during hospitalization for decompensated diabetes mellitus (DM). In...
Adrenocortical cancer (ACC) is a rare endocrine malignancy of the adrenal cortex, which has an unfavorable prognosis and extremely aggressive clinical behavior in most cases. Nevertheless, cases more favorable disease course with late metastasis slow progression have been described. In 2017, International Agency for Research on Cancer (IARC) World Health Organization (WHO) 4th edition Classification Tumors Endocrine Organs identified histological variants ACC, such as classical, oncocytic,...
Studies of the last decade have demonstrated that morphological and immunophenotypic patterns adrenocortical carcinoma (ACC) a high heterogeneity in both occurrence various tumors development solitary tumor. Carcinogenesis ACC, like most neoplastic processes, is associated with mutations at least 15 driver genes, wide range chromosomal aberrations, epigenomic changes, alterations microRNA profile. According to literature, isolated genetic damage also insufficient for manifestation malignant...
In this article, we discuss difficulties in parathyroid localization modalities diagnosis of primary hyperparathyroidism. Most often, superior glands are located on the posteromedial surface right and left lobes thyroid gland, however, they also could be found at carotid bifurcation, behind pharynx esophagus, as well inside gland. Location inferior is more variable: side or back surface, below lower pole thymus, posterior anterior mediastinum, thyroid. Localization hyperparathyroidism based...
The steadily growing interest in studying of endocrine genetics is driven not only by the search for new pathologies but also most pressing need to develop methods early diagnosis, treatment and management patients. Though 20% all patients with von Hippel-Lindau syndrome do have a family history disease; genetic basis natural characteristic disease determinates phenotype. Despite nonaggressive course, general, relative unpredictability signs onset lack regular monitoring can increase risk...
Adrenocortical carcinoma is a rare malignant tumor of the adrenal cortex with an unfavorable prognosis. In 2017, International Agency for Research on Cancer (IARC) and World Health Organization (WHO) published 4th edition WHO Classification Tumors Endocrine Organs. The updated classification reflects multidisciplinary experience in diagnosing predicting course tumors, obtained basis current studies. This paper highlights key provisions adrenocortical carcinoma.Адренокортикальный рак - это...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Introduction : Pheochromocytoma (PC) and paraganglioma (PG) are rare neuroendocrine tumors derived from adrenal chromaffin cells. The main options of systemic therapy for PC / PG alkylating agent-based chemotherapy (ChT) targeted with sunitinib. There no comparative data on the efficacy these options, which became purpose this study. Materials methods This retrospective single-center study included patients over 18 y. o. who received ChT or first line treatment metastatic September 2015 to...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract The prevalence of metastatic pheochromocytoma/paraganglioma (PPGL) is reported to be 3% 36% all the cases. five-year overall survival rate such patients ranges from 40 77%. management PPGL challenging taking into account fact that optimal strategies for clinical care beyond surgical resection are not guided yet. Peptide receptor radionuclide therapy (PRRT) using somatostatin analogues effective in other neuroendocrine tumours, can indicated with positive scans respective...
Differentiation between benign, primary and secondary malignant tumors is a critical problem in the clinical treatment of adrenal tumors, especially patients with isolated lesions. In most cases, correct diagnosis can be established microscopically standard staining hematoxylin eosin. However, there are cases when it almost impossible to distinguish metastasis from cancer, so an accurate requires immunohistochemical examination.This article presents five unique observations that were...
Background: Adrenalectomy is standard of care for phaeochromocytomas, but bilateral phaeochromocytoma, the recommendations are inconsistent. However, large studies systematically investigating long-term outcomes total adrenalectomies compared to those patients with adrenal-sparing operations lacking. Methods: A multi-center consortium-based registry was established study clinical, genetic and surgical data in 623 phaeochromocytomas. Findings: Of patients, median age at diagnosis 30 (range...
Abstract Background: Serum basal calcitonin (bCT) is used as a biomarker of medullary thyroid carcinoma (MTC) but bCT can also be elevated in patients with hypercalcemias, hypergastrinemias, thyroiditis, neuroendocrine tumors, renal end-stage kidney disease, obesity and cigarette smoking. The application measured the FNA washout fluid sample (FNA-CT) for screening certain nodular thyroidopathy controversial. Case: A 44 yo patient presented level - 24pg/ml (N male &lt;18). He had morbid...
Abstract Evidence on the diagnostic performance of 18F-fluorodeoxyglucose(18FDG) positron emission tomography(PET)/CT imaging adrenal lesions is limited. We aimed to assess this modality in a high risk population for malignancy using an optimal reference standard. included 21 patients operated our clinic during 2019 whom 8FDG PET was performed before adrenalectomy. 3 with pheochromocytoma were later excluded from statistical analysis, they sent increased urine metanephrines received....
Background. Combination of gemcitabine, metronomic capecitabine and mitotane (GemCap + m) is the most studied regimen in second subsequent lines therapy for advanced adrenocortical cancer (ACC). Previously published studies do not give a definitive answer to question- what plays key role realizing response treatment: chemotherapy or therapeutic concentration. Aim. Evaluation efficacy safety GemCap m combination with standard dosing patients metastatic ACC. Materials methods. This...
Abstract Background Mitotane/o,p'DDD is adrenolytic and antitumor therapeutic agent used in the first line drug therapy of advanced adrenocortical carcinoma (ACC) as well an adjuvant after surgical resection primary tumor at moderate/high risk recurrence. Mitotane a metabolite endocrine disruptor DDT classified among teratogenic compounds. Preterm births early pregnancy loss have been reported female patients exposed to mitotane during pregnancy. Clinical Case At age 33, patient underwent...
Ziel/Aim Treatment of metastatic pheochromocytomas and paragangliomas (MPPG) remains challenging. In case a local recurrence or localized metastses, surgery radiotherapy represent treatment options. Systemic chemotherapy radionuclide therapy using 131I-mIBG are limited efficacy. Peptide receptor (PRRT) somatostatin analogues was proposed as an alternative therapeutic approach.