A5019332896- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Gut microbiota and health
- Oral microbiology and periodontitis research
- Probiotics and Fermented Foods
- Immunotherapy and Immune Responses
- Multiple Sclerosis Research Studies
- Hormonal Regulation and Hypertension
- Neuroblastoma Research and Treatments
- Acne and Rosacea Treatments and Effects
- Cytokine Signaling Pathways and Interactions
- Leprosy Research and Treatment
- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Thyroid Disorders and Treatments
- Genomics and Chromatin Dynamics
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Transgenic Plants and Applications
- Plant Virus Research Studies
- Ziziphus Jujuba Studies and Applications
- Bacterial biofilms and quorum sensing
- T-cell and B-cell Immunology
- Genetically Modified Organisms Research
North Minzu University
2025
Central South University
2006-2022
Wound Healing Society
2021
Xiangya Hospital Central South University
2017-2019
Shanghai Ninth People's Hospital
2019
HBIS (China)
2004
Background: The threat of drug-resistant Pseudomonas aeruginosa requires great efforts to develop highly effective and safe bactericide. Objective: This study aimed investigate the antibacterial activity mechanism silver nanoparticles (AgNPs) against multidrug-resistant P. . Methods: antimicrobial effect AgNPs on clinical isolates resistant P was assessed by minimal inhibitory concentration (MIC) bactericidal (MBC). In , alterations morphology structure were observed transmission electron...
<h3>Importance</h3> Large studies investigating long-term outcomes of patients with bilateral pheochromocytomas treated either total or cortical-sparing adrenalectomies are needed to inform clinical management. <h3>Objective</h3> To determine the association vs adrenalectomy pheochromocytoma-specific mortality, burden primary adrenal insufficiency after adrenalectomy, and risk pheochromocytoma recurrence. <h3>Design, Setting, Participants</h3> This cohort study used data from a multicenter...
DNA methylation is one of the earliest and most extensively studied epigenetic regulatory mechanisms. The ROS1 (Repressor Silencing 1) gene was first discovered in Arabidopsis thaliana, it a demethylase that can remove 5-methylcytosine from DNA, thereby affecting levels expression. Objectives: objective this study to investigate role development maturation Ziziphus jujuba cv. "Dongzao" fruit. Methods: We cloned conducted bioinformatics expression characteristics analyses on it. Results:...
Pheochromocytoma and paraganglioma (PCC/PGL) are rare tumors that originate from adrenal or extra-adrenal chromaffin cells. A significant clinical manifestation of PCC/PGL is the release a large number catecholamines continuously intermittently, causing persistent paroxysmal hypertension multiple organ functions metabolic disorders. Though majority non-metastatic, about 10% metastatic tumors. Others even have estimated rate metastasis may be as high 26%. The disease most common in...
Background Macrolides have been widely used to treat moderate-to-severe acne for more than 50 years. However, the prevalent antibiotic resistance of Propionibacterium acnes, along with absence clinically available tests, has made macrolide misuse a frequent occurrence around globe, serious consequences. Objective We developed Cutibacterium acnes quantitative PCR (qPCR)-based antibiotics assay (ACQUIRE) enable fast and accurate detection C. in clinical settings, representing an opportunity...
The pathogenesis of multiple sclerosis (MS) is mediated primarily by T cells, but most studies MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have focused on CD4 cells. aims the current study were to determine pathological interrelationship between CD8 autoreactive cells in MS/EAE.Female C57BL/6 mice (n = 20) induced myelin oligodendrocyte glycoprotein (MOG)35-55 peptide. At 14 days after immunization, isolated from spleen purified as using isolation kits, then...
Pheochromocytoma, as a neuroendocrine tumor with the highest genetic correlation in all types of tumors, has attracted extensive attention. Von Hipper Lindau (VHL) mutation frequency among genes associated pheochromocytoma. However, effect VHL on proteome pheochromocytoma remains to be explored. In this study, knockdown (VHL-KD) PC12 cell model was established by RNA interference (shRNA). We compared proteomics VHL-KD and VHL-WT lines. The results showed that expression 434 proteins (VHL...
Background: Huangqi Guizhi Wuwu decoction (HQGZWW) exhibits good effects when administered to treat multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Understanding the precise mechanism of this is thus important. Based on findings our previous study, aim present study was understand role antigen-specific CD8 + T-cells pathogenesis MS/EAE HQGZWW as treatment. Methods: Myelin oligodendrocyte glycoprotein (MOG) 35-55 -induced mice were distilled...
Background: The Von Hippel-Lindau (VHL) p.Tyr98His (Y98H) mutation is designated as the "Black Forest" founder and has been previously reported in Western countries. This study reports first recorded Chinese VHL family with Asia. Methods: Paired whole-exome sequencing (WES), Sanger immunohistochemistry (IHC) were performed on samples from a large to confirm causative carriers family. Clinical manifestations of summarized compared those other patients Y98H mutation. Results: pheochromocytoma...
Thyroid eye disease (TED), an orbital inflammatory status, generally occurred in Graves' disease.This study aimed to acquire further insight into molecular mechanisms of TED, especially several key involved genes and pathways.The microarray dataset GSE58331 including expression data for adipose tissue samples, isolated from TED patients normal controls, was downloaded a publicly accessible Gene Expression Omnibus database. Differentially expressed (DEGs) were identified 23 tissues versus 20...
To identify 14 bacteria by sequencing the 16S rRNA gene and establish basis for clinical application in future.DNA samples of were extracted. The genes amplified PCR sequenced with common primers. sequences aligned online software Blastn nucleotide database. identified according to homology their genes.Twelve classified species, other 2 genus.16S sequence analysis is useful identifying pathogenic bacteria.
Heterozygous germline mutation of the MEN1 tumor suppressor gene is responsible for multiple endocrine neoplasia type 1. Parathyroid and thoracic neuroendocrine specimens DNA from two Han Chinese family patients were analyzed using whole exome Sanger sequencing. The proband (II-3) was sequentially diagnosed with pituitary adenoma, pancreatic tumor, adrenal cortical abdominal lipoma, parathyroid adenoma during 6-year follow-up. son (III-6) also a this period. Splice alterations studied by...
The microbiota in the human gut is not only a complicated microecological system but also plays important roles both health and disease. In order to understand of these bacteria, we determined distribution different regions by sequencing 16S rRNA gene V4 region bacteria saliva, gastric juice, stool healthy individuals. V3-V5 sequences saliva were obtained from Human Microbiome Project (HMP) sequence was program designed Perl language. We found that juice more similar those rather than stool....
Background: Adrenalectomy is standard of care for phaeochromocytomas, but bilateral phaeochromocytoma, the recommendations are inconsistent. However, large studies systematically investigating long-term outcomes total adrenalectomies compared to those patients with adrenal-sparing operations lacking. Methods: A multi-center consortium-based registry was established study clinical, genetic and surgical data in 623 phaeochromocytomas. Findings: Of patients, median age at diagnosis 30 (range...
The microbiota in the human gut is not only a complicated microecological system but also plays important roles both health and disease. In order to understand of these bacteria, we determined distribution different regions by sequencing 16S rRNA gene V4 region bacteria saliva, gastric juice, stool healthy individuals. V3-V5 sequences saliva were obtained from Human Microbiome Project (HMP) sequence was program designed Perl language. We found that juice more similar those rather than stool....
Abstract Background: Current modern conventional medicine (MCM) on multiple sclerosis (MS) are non-specific immunosuppressive drugs, which remains many side effects. Huangqi Guizhi Wuwu decoction (HQGZWW) is a common formula of Chinese herbal (CHM) has good effects treatment MS and its animal model, experimental autoimmune encephalomyelitis (EAE) very well, so it important to understand the precise mechanism. Our previous study suggested that CD8 + autoreactive T cells in EAE had lower...
Abstract Background Macrolides have been widely used to treat moderate-to-severe acne for more than 50 years. However, prevalent antibiotic resistance of Propionibacterium acnes , along with the absence clinically available tests, has made macrolide misuse a frequent occurrence, serious consequences. Objective We developed P. qPCR-based antibiotics assay (ACQUIRE) enable fast and accurate detection in clinical settings, representing an opportunity administer wisely improve quality care....