A5065419411- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Virus-based gene therapy research
- Oral and Maxillofacial Pathology
- Microbial infections and disease research
- Tumors and Oncological Cases
- Mast cells and histamine
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Vascular Tumors and Angiosarcomas
- Urological Disorders and Treatments
- Animal health and immunology
- Ear and Head Tumors
- Cancer Diagnosis and Treatment
- Renal and related cancers
- Veterinary Medicine and Surgery
- Veterinary Orthopedics and Neurology
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Soft tissue tumor case studies
- Parasitic infections in humans and animals
- Cancer Cells and Metastasis
- Inflammatory mediators and NSAID effects
- Cardiac tumors and thrombi
University of Bologna
2015-2024
University of Turin
2019
University of Siena
2014
Veterinary Oncological Center
2012
GNA University
2010
St. Luke's-Roosevelt Hospital Center
1976
Columbia University
1976
A retrospective collection of 171 lymphoid neoplasms (123 dogs and 48 cats) was classified according to the Revised European-American Lymphoma (REAL) classification, adopted in 2002 by World Health Organization (WHO), evaluate WHO system for categorization canine feline neoplasms. Microscopic examination performed after standard hematoxylin-eosin staining immunohistochemical labelling B (CD79a) or T (CD3) cell phenotypes. B-cell lymphomas were prevalent T-cell cats. B-Large lymphoma (B-LCL)...
To compare the Kiupel (2 categories) and Patnaik (3 histologic grading systems for predicting presence of metastasis at time initial examination in dogs with cutaneous mast cell tumors (MCTs).Retrospective case series.386 client-owned MCTs.Medical records newly diagnosed, histologically confirmed MCTs that had undergone complete clinical staging were reviewed histopathologic data.All grade 1 (n = 52) classified as low-grade MCTs, all 3 (43) high-grade MCTs. Of 291 2 243 (83.5%) tumors, 48...
To investigate the mechanisms which enable diaphragm to preserve ventilation when work of breathing is elevated, we measured diaphragmatic blood flow (Q di) and oxygen consumption (VO2 in lightly anesthetized dogs. The animals were studied they breathed quietly, inhaled 5% CO2 21% or 14% O2, these gas mixtures through moderate severe inspiratory resistances. Q di was determined from integrated arteriovenous difference krypton-85, by Kety-Schmidt technique. VO2 calculated as product ([A-V]O2...
Mast cell tumor (MCT) is a common canine cutaneous neoplasm with variable biological behavior. A 2-tier histologic grading system was recently proposed by Kiupel et al to reduce interobserver variation and eliminate prognostic uncertainty of the Patnaik system. This study compared ability these 2 systems predict survival in cohort dogs MCTs. However, surgical margins were unknown, risk developing new/metastatic MCTs not studied. Histologic grade assessed according both for 137 surgically...
Histologic grading of canine cutaneous mast cell tumors (cMCTs) has prognostic and therapeutic implications, yet validation for subcutaneous MCTs (scMCTs) is lacking. For scMCTs with or without dermal invasion, determining their biological behavior remains poorly standardized sometimes sparks controversy. This prospective study aimed to assess the utility 2-tier histologic system in different growth models (GMs) explore impact GM itself. We assessed 6 categories: solely cMCT (C-SC 0 ),...
To describe clinical characteristics, treatment, and outcome of dogs with inflammatory carcinoma (IC) identify patient-, tumor-, treatment-related factors associated overall survival time.Retrospective case series.43 client-owned dogs.Records a diagnosis IC that had histologic evidence dermal lymphatic invasion were reviewed. Data on staging, toxicoses, response, time retrieved. Results-26 (60%) primary 17 (40%) secondary IC. Thirty-five (81%) distant metastases 2 (5%) local at the initial...
To assess the usefulness of histologic evaluation surgical margins to predict local recurrence cutaneous malignant tumors in dogs and cats treated by means excision.Prospective case series.40 20 cats.60 surgically excised (20 soft tissue sarcomas [STSs], mast cell [MCTs], carcinomas) were examined histologically. Margins classified as clean, close, or infiltrated; grade was assessed STSs MCTs. Recurrence rates recurrence-free intervals (RFIs) during a 24-month follow-up period recorded,...
Abstract A cytological grading for mast cell tumours ( MCTs ) would be highly desirable, allowing to select the most appropriate therapeutic intervention prior surgery. This study evaluates applicability on fine‐needle aspirations FNAs of novel Kiupel system, based number mitoses, multinucleated cells, bizarre nuclei and presence karyomegaly. Fifty consecutive cases with pre‐operative diagnosis were included. In specimens, approximately 1000 cells evaluated, histological grade was assessed...
This study aimed to evaluate the agreement between microscopic and molecular testing for differentiating feline intestinal bowel disease small cell alimentary lymphoma in duodenal endoscopic biopsies.Four different diagnostic methods (cytology, histology, immunohistochemistry clonality) were sequentially applied 77 cases of chronic enteropathies. The was calculated survival data obtained assess most reliable method predicting outcome.Seventy-seven included study. On multivariate analysis,...
Mast cell tumors (MCTs) with bone marrow (BM) involvement are poorly documented in dogs and associated a poor prognosis. Successful treatment strategies have not been described.Clinicopathologic findings of affected specific. Administration lomustine or imatinib is beneficial.Fourteen MCT BM involvement.Clinical laboratory evaluations were performed each dog on admission during follow-up. All received prednisone. Additionally, 8 3 imatinib. Imatinib was administered if tumor-associated...
Feline cutaneous mast cell tumors (MCTs) have been histologically classified as mastocytic (well differentiated or pleomorphic) and atypical/poorly granulated. Their biologic behavior ranges from benign to malignant, but prognostic factors are not well defined. Histologic classification, number of tumors, mitotic index, cytoplasmic granularity, infiltration by eosinophils lymphocytes were evaluated retrospectively in 25 feline MCTs. Immunohistochemistry was applied assess KIT (CD117) pattern...
Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis response to therapy in a variety of human cancers. KRAS mediates the transduction signals between EGFR nucleus, mutation has been identified as predictor resistance anti-EGFR drugs. In oncology, importance EGFR/HER-2/KRAS signalling pathway gastric cancer is well established, HER-2 testing required before initiating therapy. Conversely, this never...
Abstract Background Canine subcutaneous mast cell tumours (ScMCTs) reportedly have a good prognosis. However, biomarkers that can be used to predict outcome are currently limited. Methods A multicentre prospective study was conducted identify new prognostic markers. Dogs with first occurrence of ScMCT were enrolled upon primary tumour removal and regional lymphadenectomy. In the absence metastasis, dogs monitored, while overtly metastatic lymph nodes (histological node 3, HN3) received...
CD117 is a transmembrane tyrosine kinase growth factor receptor expressed by variety of normal human cell types, including germ cells, immature myeloid and mast cells. To evaluate the pattern expression in dogs cats, we applied polyclonal antibody on paraffin sections from 44 samples tissues 104 tumors. In both species, strong immunoreactivity was observed interstitial cells Cajal, Among gastrointestinal mesenchymal neoplasms, five one cat revealed expression, enabling us to identify them as...
Increased cancer rates have been documented in people residing areas around Naples characterized by illegal dumping and incineration of waste.Risk dogs cats is associated with waste management.Four hundred fifty-three 1,554 cancer-free animals.Hospital-based case-control study (low danger) nearby cities having a history (high danger). Odds ratio (OR) between high- low-danger was calculated for all tumors various malignancies cats.An increased risk development identified but not high-danger...
Abstract Feline head and neck squamous cell carcinoma (SCC) is a loco‐regional disease harbouring poor prognosis. The complex anatomic location precludes aggressive surgical resection tumours recur within weeks to few months. Response chemotherapy local control after radiation therapy has been disappointing. In this study, multimodal approach including medical treatment (thalidomide, piroxicam bleomycin), (accelerated, hypofractionated protocol) surgery was attempted in six cats. Treatment...
Feline cutaneous mast cell tumors (FeCMCTs) are characterized by variable biological behavior. Development of multiple nodules and potential visceral involvement, along with inconsistency conventional prognostic aids, justify uncertainty in differentiating benign from malignant forms. c-Kit proto-oncogene activating mutations have been reported feline (MCTs), but their relevance was not investigated. This study performed on FeCMCTs clinical outcome to assess whether Kit cytoplasmic...
Background Osteosarcoma (OSA) should be differentiated from other less frequent primary bone neoplasms, metastatic disease, and tumor‐like lesions, as treatment prognosis can vary accordingly. Hence, a preoperative histologic diagnosis is generally preferred. This requires collection of multiple biopsies under general anesthesia, with possible complications, including pathological fractures. Fine‐needle aspiration cytology would allow an earlier significant reduction discomfort morbidity....
Feline large granular lymphocyte ( LGL ) lymphoma is an uncommon subtype of characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico‐pathological prognostic factors. One‐hundred 9 cats with newly diagnosed that underwent initial staging (including hematology, serum biochemistry, thoracic radiographs abdominal ultrasound), followed‐up were retrospectively evaluated. was localized within the gastrointestinal tract or without extra‐intestinal...
This study reports the main clinicopathological features of primary lung cancer (PLC) in 37 dogs, with special regard to pathogenetic and prognostic role epidermal growth factor receptor (EGFR) overexpression. For each case following characteristics were evaluated: tumour-node-metastasis (TNM) stage, tumour histotype, histological grade, mitotic activity immunohistochemical expression EGFR. In samples available normal tissue, amount background anthracosis was also measured by image analysis....
Saccharomyces boulardii is used to treat acute and chronic enteropathies in humans, but date, no studies have evaluated the use of this yeast dogs. The current study, a prospective non‐randomised, double‐blinded, placebo‐controlled effects S healthy dogs with (CE). Four 20 CE were included. In dogs, was administered for 10 days. Possible short‐term adverse recorded, quantitative stool cultures yeasts performed. CE, or placebo addition standard treatment protocols. Canine Chronic Enteropathy...
Cutaneous mast cell tumors (cMCTs) account for approximately 20% of skin neoplasms in cats. As there is no grading system these tumors, prognosis difficult to estimate. Although the typical presentation a benign tumor that can be cured by surgical excision, small but important proportion feline cMCTs biologically aggressive and spread local lymph nodes, precede onset disseminated cutaneous disease, or associated with visceral involvement. A number macroscopic histologic features were...