A5074441183- Bone health and treatments
- Palliative Care and End-of-Life Issues
- Cancer Diagnosis and Treatment
- Pain Management and Opioid Use
- Bone Metabolism and Diseases
- Cancer survivorship and care
- Management of metastatic bone disease
- Erythrocyte Function and Pathophysiology
- Radiopharmaceutical Chemistry and Applications
- Blood properties and coagulation
- Cancer Treatment and Pharmacology
- Neuroendocrine Tumor Research Advances
- Pharmacological Effects and Toxicity Studies
- Pain Management and Placebo Effect
- Cancer Genomics and Diagnostics
- Pain Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Pediatric Pain Management Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Gastrointestinal Tumor Research and Treatment
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2014-2024
University of Pisa
2013-2021
Ghent University
2014
As hormone receptor and human epidermal growth factor receptor-2 (HER-2) expression in primary breast tumors frequently differs from that of paired metastases, we first evaluated the discordance rate (DR) estrogen (ER), progesterone (PgR), HER-2, Ki67 cancer patients then assessed effect on prognosis.Of 145 cases reviewed, 120 with samples available both metastases were included study. For each receptor, DR was calculated as proportion discordant respect to total number patients.A change ER...
Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis response to therapy in a variety of human cancers. KRAS mediates the transduction signals between EGFR nucleus, mutation has been identified as predictor resistance anti-EGFR drugs. In oncology, importance EGFR/HER-2/KRAS signalling pathway gastric cancer is well established, HER-2 testing required before initiating therapy. Conversely, this never...
The aim of this study was to assess the efficacy and adverse effects methadone when used as first-line therapy in patients that are either receiving low doses opioids or none.Patients with advanced cancer were prospectively assessed. Opioid-naive (L-group) started at 6 mg/day. Patients weak other <60 mg/day OME (H-group) 9 Methadone changed according clinical needs obtain most favorable balance between analgesia effects. Edmonton Symptom Asssement Score (ESAS), Memorial Delirium Assessment...
To investigate the efficacy of platinum-based chemotherapy in patients with metastatic gastroenteropancreatic neuroendocrine carcinoma (mGEP-NEC) and define predictive prognostic factors.Twenty mGEP-NEC were treated cisplatin or carboplatin/etoposide between April 2010 October 2014. Both large-cell small-cell histologies included. Cisplatin 25 mg/m(2) was administered on days 1-3 followed by etoposide 100 every 21 days. Carboplatin 300 day 1 1-3.Of 19 evaluable patients, 13 obtained a...
Bone metastases are a frequent event in patients with solid tumors. Although great advances have been made the treatment of these patients, identification novel, accurate indicators bone response would greatly facilitate clinical management disease. The receptor activator nuclear factor-κB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) signaling pathway is significantly involved metastasis formation. main aim present study was to evaluate role circulating RANK, RANKL and OPG levels...
Patients with solid cancer frequently develop bone metastases (BM). Zoledronic acid (Zometa®, ZA), routinely used to treat patients BM, acts on osteoclasts and also has antitumor properties. We aimed assess the effect of ZA over time in novel turnover markers (RANK/receptor activator nuclear factor-k B ligand (RANK-L)/ Osteoprotegerin (OPG)) correlate these serum N-terminal telopeptide (NTX). The study prospectively evaluated levels RANK, RANK-L OPG transcripts by real-time PCR NTX...
Advances in the diagnosis and treatment of tumors by surgery, chemotherapy, biotherapy, radiotherapy other modalities have increased survival cancer patients over last 20 years. As a consequence, bone now represents third most common site metastatic involvement after lung liver. Approximately 20-25% with neoplastic disease develop clinically evident metastases (BMs) during natural course their illness, further 50% such lesions being identified autopsy. BMs are major cause morbidity because...
Abstract Chronic pain is often difficult to treat, requiring a comprehensive multidisciplinary therapeutic intervention and high level of management expertise. This particularly true for patients who are unresponsive standard treatments chronic pain, which Scrambler Therapy (ST) indicated. The aim the present study was evaluate impact ST on patient-reported moderate severe pain. prospective trial 219 affected by from April 2010 March 2016. consisted 2 consecutive weeks treatment with (one...
Background: We present a retrospective analysis of metronomic capecitabine in metastatic gastroenteropancreatic neuroendrocrine tumors (GEP-NETs). A review the literature is also presented. Methods: From January 2007 to December 2013, ten patients with GEP-NETs (four pancreatic and six ileal) who progressed after treatment somatostatin analogs other cytotoxic agents received oral 1,500 mg/day continuously. The median patient age was 68 (range 29–82) years. duration 8 months. Results: Five...
Gastrointestinal stromal tumors are rare malignancies characterized by c-kit and PDGFR-α mutations targeted imatinib. Pleural effusion is a very side effect of imatinib treatment. A 65-year-old female with metastatic gastrointestinal tumor developed electrolyte imbalance, severe peripheral edema progressively worsening dyspnea 2 months after starting Having excluded cardiovascular pulmonary disorders, was discontinued prednisone 25 mg orally daily begun. The patient's condition improved...
Malignant tumors of the lacrimal gland are rare, and single bone metastases from carcinoma an exceptional event. We present case a 71-year-old man with history lumbar pain left exophthalmos. Surgical resection lesion biopsy gave final histopathological diagnosis primary ductal adenocarcinoma metastasis. The pathological tissue both procedures was positive for androgen receptor expression. patient underwent embolization radiotherapy in association total blockade. After 20 months, is still...
New treatments have improved the overall survival of patients with multiple myeloma (MM). At diagnosis and during course disease, often report pain other symptoms. Given long disease trajectory, psychological social issues are also frequent. Recently, potential usefulness early palliative care (EPC) was hypothesized in area hematology. We conducted a retrospective analysis MM referred to our institute for (PC) consultation between January 2017 June 2020. Our aim evaluate main reasons (pain...
Background Prognostication can be used within a tailored decision-making process to achieve more personalized approach the care of patients with cancer. This prospective observational study evaluated accuracy Palliative Prognostic score (PaP score) predict survival in identified by oncologists as candidates for palliative radiotherapy (PRT). We also studied interrater variability clinical prediction and PaP scores assessed Survival Prediction Score (SPS) TEACHH score. Materials methods...
Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma derived from smooth muscle cells typically of uterine, gastrointestinal or origin. The prognosis for this tumor poor, with survival rates among the lowest all sarcomas. Surgery best approach localized disease. principal role chemotherapy prevalently in treatment metastatic Trabectedin, a promising new DNA-damaging agent mechanism action that differs traditional alkylating agents, has been approved Europe patients advanced after...
Abstract Aim and objectives To present our experience of a nursing telephone consultation service, describing patient caregiver requests, outlining ensuing or medical interventions. Background Recently, there has been an increase in the use for cancer patients. However, is still limited data on characteristics this type service nature interventions carried out. Design methods In observational retrospective study, we evaluated phone calls made over 6‐month period by patients caregivers to...
On the basis of substantial evidence demonstrate that palliative care combined with standard improves patient, caregiver, and society outcomes, we have developed a new healthcare model called radiotherapy (RaP) outpatient clinic were radiation oncologist physician make joint evaluation advanced cancer patients.We performed monocentric observational cohort study on patients referred for at RaP clinic. Measures quality carried out.Between April 2016 2018, 287 evaluations 260 evaluated. The...
Introduction It is estimated that of those who die in high-income countries, 69%–82% would benefit from palliative care with a high prevalence advanced chronic conditions and limited life prognosis. A positive response to these challenges consist integrating the approach into all healthcare settings, for patients types medical conditions, although poor clinician awareness difficulty applying criteria identify need still pose significant barriers. The aim this project investigate whether...
The presence of unusual two RBCs patterns (so-called "quatrefoil RBCs," qRBCs) on canine blood smears at Optical Microscope (OM) was seen during routine evaluation CBCs. Two consecutive retrospective investigations were arranged including about 7,000 CBCs and clinical records laboratory data from dogs showing qRBCs. Few samples with qRBCs prepared for Scanning Electron (SEM). found in 6.89% (139 2016) 8.47% (133 1569) 3.89% (154 3,958) 4.47% (138 3,081) (some tested more than once)....
e19591 Background: Chronic cancer pain (CCP) is present in 50% of patients at any stage disease and 70% those an advanced setting. Preliminary results have shown the effectiveness Scrambler therapy, which uses electroanalgesia to neuromodulate cancer-related neuropathic pain. The machine supported by a multiprocessor computer capable simulating 5 artificial neurons that send out signals identified central nervous system as “no pain.” In this way information can be conveyed through electrodes...