A5006667362- Palliative Care and End-of-Life Issues
- Patient Dignity and Privacy
- Management of metastatic bone disease
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Palliative and Oncologic Care
- Calcium signaling and nucleotide metabolism
- CNS Lymphoma Diagnosis and Treatment
- Pain Management and Opioid Use
- Effects of Radiation Exposure
- Geological Modeling and Analysis
- Optimism, Hope, and Well-being
- Artificial Intelligence in Healthcare and Education
- Radiomics and Machine Learning in Medical Imaging
- Metabolism, Diabetes, and Cancer
- Oral health in cancer treatment
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Science Systems and Applications (United States)
2024
Goddard Space Flight Center
2024
Istituto Oncologico Veneto
2023
Istituto per la Ricerca Sociale
2023
Azienda Ospedaliera di Padova
2023
Guglielmo da Saliceto Hospital
2014-2015
Ospedaliera di Piacenza
2014
The endothelin axis, comprising endothelins (ET-1, ET-2 and ET-3) their receptors (ETAR ETBR), has emerged as relevant player in tumor growth metastasis. Here, we investigated the involvement of ET-1/ETAR axis chronic lymphocytic leukemia (CLL). CLL cells expressed higher levels ET-1 ETA receptor compared to normal B cells. peptide stimulated phosphoinositide-3-kinase mitogen-activated protein kinase signaling pathways, improved survival promoted proliferation leukemic throughout ETAR...
Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not suitable for high dose chemotherapy with autologous stem cell transplantation (ASCT) has a dismal prognosis and no standard therapy. We designed an Italian multicenter retrospective study aimed at evaluating the safety efficacy of rituximab plus bendamustine (R–B) as salvage treatment in patients eligible ASCT because age and/or comorbidity post-ASCT recurrence. Fifty-five median 76 years were included. The overall response...
Background: Bone metastases (BMs) are a common complication in patients with cancer, often leading to significant pain that adversely affects quality of life, necessitating effective management strategies. This study aims evaluate the effectiveness BMs undergoing palliative radiotherapy and identify determinants adequacy. Methods: We conducted an observational analysis 560 from Palliative Radiotherapy Inflammation Study (PRAIS) trial across several European centers, focusing on Pain...
Abstract Purpose Patients with haematologic malignancies have less access to palliative care and are referred later than patients solid tumours. We developed a survey investigate this phenomenon, the intention of analysing perceptions among health professionals who treat haematology identifying barriers facilitators referrals services. Methods This was multicentre exploratory descriptive web-based survey. A questionnaire administered 320 medical nursing staff members from five Italian...
PURPOSE The estimation of prognosis and life expectancy is critical in the care patients with advanced cancer. To aid clinical decision making, we build a prognostic strategy combining machine learning (ML) model explainable artificial intelligence to predict 1-year survival after palliative radiotherapy (RT) for bone metastasis. MATERIALS AND METHODS Data collected multicentric PRAIS trial were extracted 574 eligible adults diagnosed metastatic primary end point was overall (OS) at 1 year...
New treatments have improved the overall survival of patients with multiple myeloma (MM). At diagnosis and during course disease, often report pain other symptoms. Given long disease trajectory, psychological social issues are also frequent. Recently, potential usefulness early palliative care (EPC) was hypothesized in area hematology. We conducted a retrospective analysis MM referred to our institute for (PC) consultation between January 2017 June 2020. Our aim evaluate main reasons (pain...
Abstract Aim and objectives To present our experience of a nursing telephone consultation service, describing patient caregiver requests, outlining ensuing or medical interventions. Background Recently, there has been an increase in the use for cancer patients. However, is still limited data on characteristics this type service nature interventions carried out. Design methods In observational retrospective study, we evaluated phone calls made over 6‐month period by patients caregivers to...
On the basis of substantial evidence demonstrate that palliative care combined with standard improves patient, caregiver, and society outcomes, we have developed a new healthcare model called radiotherapy (RaP) outpatient clinic were radiation oncologist physician make joint evaluation advanced cancer patients.We performed monocentric observational cohort study on patients referred for at RaP clinic. Measures quality carried out.Between April 2016 2018, 287 evaluations 260 evaluated. The...
Introduction It is estimated that of those who die in high-income countries, 69%–82% would benefit from palliative care with a high prevalence advanced chronic conditions and limited life prognosis. A positive response to these challenges consist integrating the approach into all healthcare settings, for patients types medical conditions, although poor clinician awareness difficulty applying criteria identify need still pose significant barriers. The aim this project investigate whether...
The development of Earth System Digital Twins (ESDTs) represents an ongoing journey towards more accurate and integrated simulations processes. Inherently interdisciplinary, the endeavor grapples with challenge melding subsystems developed by experts in different fields organizations, requiring communication between science domains, technology stacks, data modalities. Coupled Reusable Tensor (CREST) framework is a key aspect our efforts to address these difficulties: implementing generic...
Abstract Introduction Patients with hematological malignancies have less access to Palliative Care and more delayed referrals than patients solid tumors. Why does this occur? This survey aims analyze the perceptions of health professionals who treat identify barriers facilitators when are referred services. Method is a multicenter, exploratory, descriptive web-based survey. A questionnaire was submitted medical nursing staff at five Italian Hematological units San Marino’s hospital. The...