A5082423091- Statistical Methods in Epidemiology
- Sepsis Diagnosis and Treatment
- Advanced Glycation End Products research
- Tissue Engineering and Regenerative Medicine
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acute Kidney Injury Research
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Respiratory Support and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer-related gene regulation
- Pulmonary Hypertension Research and Treatments
- COVID-19 diagnosis using AI
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ultrasound in Clinical Applications
- Lung Cancer Treatments and Mutations
- Genomics and Phylogenetic Studies
- Paraquat toxicity studies and treatments
Wenzhou Medical University
2016-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2025
Wenzhou Institute of Technology Testing & Calibration
2024-2025
Zhejiang University of Technology
2024-2025
Southern Medical University
2015-2024
Minzu University of China
2024
Yueyang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
State Ethnic Affairs Commission
2024
Zhujiang Hospital
2021
There is a lack of early specific diagnosis and effective evaluation sepsis, the clinical treatment not timely. As result, mortality high, which seriously threatens health people. Data were collected from human blood samples hospital by gas chromatography mass spectrometry. Thirty-five healthy controls 42 sepsis patients enrolled. Machine-learning techniques used to diagnose sepsis. Using metabolic data patients, proposed method has got 81.6% recognition rate, 89.57% sensitivity, 65.77%...
Hepatic expression profiling has revealed miRNA changes in liver diseases, while hepatic miR-155 was increased murine non-alcoholic fatty disease, suggesting that might regulate the biological process of lipid metabolism. To illustrate effects gain function transgenic mouse on metabolism, mice (i.e., Rm155LG mice) for conditional overexpression transgene mediated by Cre/lox P system were firstly generated around world this study. further crossed to Alb-Cre realize liver-specific...
Abstract The disruption of microvascular barrier in response to advanced glycation end products (AGEs) stimulation contributes vasculopathy associated with diabetes mellitus. Here, study the role Src and its association moesin, VE-cadherin focal adhesion kinase (FAK) AGE-induced vascular hyperpermeability, we verified that AGE induced phosphorylation Src, causing increased permeability HUVECs. Cells over-expressed displayed a higher after treatment, accompanied more obvious F-actin...
The breakdown of alveolar barrier dysfunction contributes to Lipopolysaccharide stimulated pulmonary edema and acute lung injury. Actin cytoskeleton has been implicated be critical in regulation epithelial barrier. Here, we performed vivo vitro study investigate role TLR4-p38 MAPK-Hsp27 signal pathway LPS-induced ALI.For studies, 6-8-week-old C57 mice were used, Bronchoalveolar lavage Fluid /Blood fluorescent ratio, wet-to-dry weight as well protein concentrations neutrophil cell counts BALF...
Proliferative diabetic retinopathy (PDR) is a progressive disease predominantly involving pathological angiogenesis and characterized by the development of immature, fragile, easily hemorrhagic new vessels. Advanced glycation end products (AGEs) receptor for AGEs (RAGE) play important roles in progression retinopathy. Our previous studies demonstrated that promoted HUVEC inducing moesin phosphorylation via RhoA/Rho-associated protein kinase (ROCK) pathway. The aim this study was to further...
Abstract Background Early and accurate identification of septic patients at high risk for ICU mortality can help clinicians make optimal clinical decisions improve the patients’ outcomes. This study aimed to develop validate (internally externally) a prediction score sepsis following admission in ICU. Methods We extracted data retrospectively regarding adult from one teaching hospital Wenzhou, China large multi-center critical care database USA. Demographic data, vital signs, laboratory...
Advanced glycation end products (AGEs), produced by the non-enzymatic of proteins and lipids under hyperglycemia or oxidative stress conditions, has been implicated to be pivotal in development diabetic vascular complications, including retinopathy. We previously demonstrated that Src kinase plays a causative role AGE-induced hyper-permeability barrier dysfunction human umbilical vein endothelial cells (HUVECs). While increase permeability is early event angiogenesis, effect angiogenesis...
Amiodarone is a potent antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis. Accumulating evidence has demonstrated myofibroblast differentiation related to the pathogenesis of In present study, we treated human embryonic lung fibroblasts (HELFs) with amiodarone, and investigated relative molecular mechanism amiodarone-induced fibrosis pathway determinants PD98059 (extracellular signal-regulated kinase (ERK) inhibitor) SB203580 (p38 mitogen-activated protein...
<title>Abstract</title> Background Pulmonary arterial hypertension (PAH) in children and adolescents is a significant global health challenge, leading to range of severe medical complications an increased risk premature death. In this study, we assessed the trends cross-country disparities burden PAH among from 1990 2021, further predicted its changes 2050. Results GBD 2021 estimated 5,049 incident cases, 1,972 deaths, 170,371 DALYs globally 2021. South Asia reported highest numbers...
The expansion of the rural middle-income group has been a global focus as it contributes to narrowing income gaps and reducing social inequality. Using data from China Family Panel Studies (CFPS), this study examines impact Internet use on mobility low-income groups perspective mobility. Controlling for household provincial-level variables, results indicate that significantly promotes group, thereby facilitating group. These conclusions hold even after conducting endogeneity robustness...
The middle class plays a crucial role in economic growth and social stability, yet the factors influencing its formation, particularly impact of Internet use, remain underexplored. This study utilizes data from China Family Panel Studies 2014 to 2020 employs Probit model examine how use affects at household level. results show significant positive relationship between middle-class formation. A series robustness checks, including instrumental variable approach, extended regression models,...
Disruption of endothelial barrier integrity in response to advanced glycation end products (AEGs) stimulation contributes vasculopathy associated with diabetes mellitus. Mammalian diaphanous-related formin (mDia1) has been reported bind the cytoplasmic domain receptor for (RAGE), which induces a series cellular processes. This study directly evaluated participation mDia1 AGE-induced hyperpermeability and revealed precise intracellular signal transductions this pathological process.Human...
To evaluate the detection accuracy of biomarkers dickkopf-1, DCP and AFP as a serum biomarker panel by comparing sensitivity with those individual biomarkers.The study was composed three groups, one HCC patients, non-HCC liver diseases healthy controls. Serum measured using chemiluminescence assay dickkopf-1 were ELISA. The specificity analyzed single parameters panel.The group showed higher levels than other two groups (P < 0.05). Dickkopf-1 better (73.26% vs. 58.13%, P 0.05) (44.0% 29.0%,...
Abstract Decellularization processes may variably distort or degrade extracellular matrix (ECM) structure. In this study, two perfusion routes (PR) were tested on SD rat lung samples. One decellularization protocol, PR1, was perfused through the pulmonary artery. The other PR2, trachea. Both protocols used by same detergent‐based (sodium dodecyl sulphate and Triton X‐100) with different flow continuous perfusion. There no visible difference in vessel architecture between PR1‐...
Background To assess whether acute kidney injury (AKI) is independently associated with hospital mortality in ICU patients sepsis, and estimate the excess AKI-related attributable to AKI. Methods We analyzed adult from two distinct retrospective critically ill cohorts: (1) Medical Information Mart for Intensive Care IV (MIMIC IV; n = 15,610) cohort (2) Wenzhou ( 1,341) cohort. AKI was defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria. applied multivariate logistic linear...
Abstract Background Diabetic angiogenesis is closely associated with disabilities and death caused by diabetic microvascular complications. Advanced glycation end products (AGEs) are abnormally accumulated in patients a key pathogenic factor for angiogenesis. The present study focuses on understanding the mechanisms underlying identifying therapeutic targets based these mechanisms. Methods In this study, AGE-induced serves as model to investigate angiogensis. Mouse aortic rings, matrigel...