A5079996901- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Porphyrin and Phthalocyanine Chemistry
- Cellular Mechanics and Interactions
- FOXO transcription factor regulation
- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Glioma Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- TGF-β signaling in diseases
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Vanadium and Halogenation Chemistry
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
University of Pennsylvania
2023-2025
California University of Pennsylvania
2024
Indian Institute of Science Bangalore
2018-2023
Abstract Loss of the tumor suppressive activity protein phosphatase 2A (PP2A) is associated with cancer, but underlying molecular mechanisms are unclear. PP2A holoenzyme comprises a heterodimeric core, scaffolding A subunit and catalytic C subunit, one over 20 distinct substrate-directing regulatory B subunits. Methylation regulates heterotrimerization, affecting binding substrate specificity. Here, we report that leucine carboxy methyltransferase (LCMT1), which methylates L309 residue acts...
The androgen receptor (AR) is a ligand-responsive transcription factor that binds at enhancers to drive terminal differentiation of the prostatic luminal epithelia. By contrast, in tumors originating from these cells, AR chromatin occupancy extensively reprogrammed hyper-proliferative, metastatic, or therapy-resistant phenotypes, molecular mechanisms which remain poorly understood. Here, we show tumor-specific enhancer circuitry critically reliant on activity Nuclear Receptor Binding SET...
Metastatic prostate cancer (PCa) is incurable and the second leading cause of death among men in Western world. Although patients initially respond to androgen deprivation therapy (ADT), most eventually develop castration-resistant (CRPC) metastasize bone. Second-generation AR signaling inhibitors, such as abiraterone acetate enzalutamide, have been shown provide a median survival benefit 6 24 months for metastatic CRPC patients. Therefore, more effective therapies are needed, including...
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates the expression of ECM-associated genes during early injury. Tissue fibrosis development driven by synergistic cues between evolving biochemical and mechanical milieu. Few studies have addressed role substrate stiffness on TGF-β activity extracellular matrix (ECM)-associated genes. We used commercial formulation polydimethylsiloxane (PDMS) to fabricate substrates 40 kPa, 300 1.5 MPa stiffness, cultured HMF3S...
Mixed-ligand oxidovanadium(IV) β-diketonates having NNN-donor dipicolylamine-conjugated to boron-dipyrromethene (BODIPY in L1) and diiodo-BODIPY (in L2) moieties, namely, [VO(L1)(acac)]Cl (1), [VO(L2)(acac)]Cl (2), [VO(L1)(dbm)]Cl (3), where acac dbm are monoanionic O,O-donor acetylacetone 1,3-diphenyl-1,3-propanedione, were prepared, characterized, tested for their photoinduced anticancer activity visible light. Complexes 1 2 structurally characterized as PF6– salts (1a 2a) by X-ray...
We introduce a self-assembling polypeptide-based nanotube system having the ability to specifically target cancer cells. The nanotubes cell surface through integrin engagement with help of multiple RGD units present along their surface. While are non-toxic towards cells in general, they can be loaded suitable drugs released sustained manner In addition, utilized for cellular imaging using any covalently tagged fluorescent dye. They stable over wide range temperature due intermolecular...
Abstract The androgen receptor (AR) is a ligand-responsive transcription factor (TF) that binds as homodimer at FOXA1-pioneered enhancer elements containing palindromic DNA motif. Prostate cancer (PCa) highly dependent on the AR enhanceosome complex, and in castration-resistant disease, this dependency reinforced through alterations pathway. This centrally involves extensive rewiring of cistrome to gain de novo binding sites (aka neo-enhancers) activate hyperproliferative metastatic gene...
Abstract Biomaterials, like polydimethylsiloxane (PDMS), are soft, biocompatible, and tuneable, which makes them useful to delineate specific substrate factors that regulate the complex landscape of cell-substrate interactions. We used a commercial formulation PDMS fabricate substrates with moduli 40 kPa, 300 1.5 MPa, cultured HMF3S fibroblasts on them. Gene expression analysis was performed by RT-PCR Western blotting. Cellular nuclear morphologies were analyzed using confocal imaging, MMP-2...