A5076471877- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Plant-based Medicinal Research
- Pituitary Gland Disorders and Treatments
- Saffron Plant Research Studies
- Climate Change and Health Impacts
- Vascular Anomalies and Treatments
- Protein Degradation and Inhibitors
- Cardiovascular and Diving-Related Complications
- Translation Studies and Practices
- Genetics, Bioinformatics, and Biomedical Research
- Echinoderm biology and ecology
- Brain Metastases and Treatment
- Ubiquitin and proteasome pathways
- Vascular Malformations and Hemangiomas
- High Altitude and Hypoxia
- Digital Humanities and Scholarship
- Radiation Effects and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Intracranial Aneurysms: Treatment and Complications
University of Pennsylvania
2023
University of Delaware
2020
Stanford University
2019
University of Utah
2012
University of Virginia Health System
2008
Neurological Surgery
2008
Object The aim of this study was to evaluate the long-term imaging and clinical outcomes intracranial arteriovenous malformations (AVMs) in children treated with Gamma Knife surgery (GKS). Methods Between 1989 2007, 200 patients AVMs who were 18 years age or younger at University Virginia Health System. Excluding 14 had not reached 2-year follow-up, 186 comprised study. Hemorrhage most common presenting symptom leading diagnosis (71.5%). mean nidus volume 3.2 cm 3 time GKS, a prescription...
Stereotactic radiosurgery serves as an important primary and adjuvant treatment option for patients with many types of intracranial meningiomas. This is particularly true parasellar In this study, the authors evaluated outcomes Gamma Knife surgery (GKS) used to treat meningiomas.The study a retrospective review in 138 meningiomas treated at University Virginia from 1989 2006; all had minimum follow-up 24 months. There were 31 men 107 women whose mean age was 54 years (range 19-85 years)....
Although numerous studies have analyzed the role of stereotactic radiosurgery for intracranial meningiomas, few assessed outcomes posterior fossa meningiomas after radiosurgery. In this study, authors evaluate treated with Gamma Knife surgery (GKS). The also assess factors predictive new postoperative neurological deficits and tumor progression.A retrospective review was performed a prospectively compiled database documenting 152 patients at University Virginia from 1990 to 2006. All had...
Abstract Loss of the tumor suppressive activity protein phosphatase 2A (PP2A) is associated with cancer, but underlying molecular mechanisms are unclear. PP2A holoenzyme comprises a heterodimeric core, scaffolding A subunit and catalytic C subunit, one over 20 distinct substrate-directing regulatory B subunits. Methylation regulates heterotrimerization, affecting binding substrate specificity. Here, we report that leucine carboxy methyltransferase (LCMT1), which methylates L309 residue acts...
Stereotactic radiosurgery has been shown to afford a reasonable chance of local tumor control. However, new brain metastasis can arise following successful control from radiosurgery. This study evaluates the timing, number, and risk factors for development subsequent in group patients treated with stereotactic alone.One hundred seventeen histologically confirmed metastatic cancer underwent Gamma Knife surgery (GKS) treat all metastases demonstrable on MR imaging. Patients were followed...
Glioblastoma multiforme tumors typically exhibit regions of hypoxia. Hypoxic within the tumor make cells less sensitive to radiosurgery and radiation therapy. Trans sodium crocetinate (TSC) has been shown be a radiosensitizer. The goal this research was elucidate underlying mechanism TSC's radiosensitizing effect.A rat C6 glioma model used. were stereotactically injected into brain create tumor. Two weeks later, MR imaging used confirm presence glioma. Following demonstration on tumor,...
Glioblastoma (GB) tumors typically exhibit regions of hypoxia. Hypoxic areas within the tumor can make cells less sensitive to chemotherapy and radiation therapy. Trans-sodium crocetinate (TSC) has been shown transiently increase oxygen hypoxic brain tumors. The authors examined whether this improvement in intratumor oxygenation translates a therapeutic advantage when delivering standard adjuvant treatment GBs.The used C6 glioma create GB model. were stereotactically injected into rat tumor....
Aggressive pituitary adenomas frequently require multimodality treatment including pituitary-suppressive medications, microsurgery, and radiation therapy or radiosurgery. The effectiveness of temozolomide in terms growth suppression decreased hormonal production is evaluated.Three adenoma cell lines--MMQ, GH3, AtT20--were used. A dose escalation was performed for each line, inhibition proliferation assessed using an MTT assay. Concentrations that produced statistically significant type were...
Background: Acute mountain sickness (AMS) is a common disease that may have pulmonary component, as suggested by interstitial edema quantified the B-line score (BLS) on ultrasound (US). This subclinical has been shown to increase with ascent high altitude and AMS severity, but not prospectively associated incidence in large prospective study. Materials Methods: observational study was part of randomized controlled trial enrolling healthy adults over four weekends ascending White Mountain,...
Williams, Brian Jeremy MD; Yen, Chun Po Starke, Robert M. MD, MSc; Basina, Bhuvaneswara Nguyen, James BA; Rainey, Jessica; Sherman, Jonathan H. BS, Schlesinger, David; Sheehan, Jason P. MD
Monteith, Stephen J. MD; Yen, Chun Po Nguyen, James BA; Rainey, Jessica; Schlesinger, David; Sheehan, Jason P. MD