A5103246487- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Molecular Biology Techniques and Applications
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Cardiac Valve Diseases and Treatments
- Cancer-related molecular mechanisms research
- Central Venous Catheters and Hemodialysis
- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Neurofibromatosis and Schwannoma Cases
- Nonmelanoma Skin Cancer Studies
- Virus-based gene therapy research
- melanin and skin pigmentation
- Air Quality and Health Impacts
- Hereditary Neurological Disorders
- Cancer, Hypoxia, and Metabolism
- Advanced Chemical Sensor Technologies
- COVID-19 Clinical Research Studies
- Metal Forming Simulation Techniques
- Cardiac and Coronary Surgery Techniques
- Anthropological Studies and Insights
- Vascular Procedures and Complications
State College of Florida Manatee-Sarasota
2023-2024
Memorial Hospital
2023-2024
University of California, Irvine
2017-2024
Beckman Laser Institute and Medical Clinic
2023
Memorial Sloan Kettering Cancer Center
2015-2022
University of Guelph
2020
Cornell University
2020
Weatherford College
2010
Institut du Thorax
2010
Palo Alto University
2007
Abstract Purpose Mechanical thrombectomy for the treatment of deep vein thrombosis (DVT) is being increasingly utilized to reduce symptoms and prevent postthrombotic syndrome (PTS), but more data on clinical outcomes are needed. was studied in ClotTriever Outcomes (CLOUT) registry with 6-month full analysis reported herein. Materials Methods The CLOUT a prospective, all-comer study that enrolled 500 lower extremity DVT patients across 43 US sites treated mechanical using System. Core-lab...
ObjectiveTo compare the comparative effects of treatment with contemporary mechanical thrombectomy or anticoagulation on Villalta scores and post thrombotic syndrome incidence through 12 months in iliofemoral deep vein thrombosis.MethodsPatients thrombosis Acute Venous Thrombosis: Thrombus Removal Adjunctive Catheter-Directed Thrombolysis (ATTRACT) randomized trial ClotTriever Outcomes (CLOUT) registry were included this analysis. Both studies evaluated thrombus removal syndrome. Patients...
Objective Compare thrombus removal and residual venous symptoms signs of disease following interventional treatment iliofemoral deep vein thrombosis (DVT) with mechanical thrombectomy (MT) pharmacomechanical catheter directed thrombolysis (PCDT). Methods Retrospective cohort analysis propensity score matched subgroups from the multicentre prospective MT ClotTriever Outcomes registry PCDT arm randomised Acute Venous Thrombosis: Thrombus Removal Adjunctive Catheter-Directed Thrombolysis trial....
Late detection and specialist referral result in poor oral cancer outcomes globally. High-risk LRMU populations usually do not have access to medicine specialists, a specialty of dentistry, whose expertise includes the identification, treatment, management cancers. To overcome this barrier, there is an urgent need for novel, low-cost tele-health approaches expand low-resource, remote underserved individuals. The goal study was compare diagnostic accuracy versus in-person visits using...
Reminder cues can destabilize consolidated memories, rendering them modifiable before they return to a stable state through the process of reconsolidation. Older and stronger memories resist this require presentation reminders along with salient novel information in order destabilize. Previously, we demonstrated rats that novelty-induced object memory destabilization requires acetylcholine (ACh) activity at M1 muscarinic receptors. Other research predominantly has focused on glutamate, which...
Endogenous human retroviruses (ERVs) are remnants of exogenous that have integrated into the genome. Using publicly available RNA-seq data from 63 cervical cancer patients, we investigated expression ERVs in cancers. Four aspects were investigated: patient ancestral background, tumor HPV type, stage and survival. Between racial subgroups, 74 significantly differentially expressed, with Black Americans having 30 upregulated 44 downregulated (including MER21C, HERV9-int, HERVH-int) when...
The relation between human papillomavirus (HPV) and extragenital Bowen's disease (BD) is controversial.This study used in situ hybridisation to evaluate the rate of HPV cutaneous BD investigated possible relations with immune status exposure skin light.HPV DNA was detected 58% 69 samples from 50 patients. percentage detection not significantly higher exposed (55%) than unexposed areas (65%), no difference found immunosuppressed immunocompetent patients.Thus, this confirms high suggests that...
Aggressive pituitary adenomas frequently require multimodality treatment including pituitary-suppressive medications, microsurgery, and radiation therapy or radiosurgery. The effectiveness of temozolomide in terms growth suppression decreased hormonal production is evaluated.Three adenoma cell lines--MMQ, GH3, AtT20--were used. A dose escalation was performed for each line, inhibition proliferation assessed using an MTT assay. Concentrations that produced statistically significant type were...
This review essay focuses on the problem of citizenship in three different areas, namely human rights, identity politics and surveillance. Heli Askola's work magnitude demographic challenges that contemporary migrant-receiving states Global North face, specifically broader picture low birth rates, increasing diversity populations ageing; thus, focusing context acquisition states. Richard Sobel's book explores empowerment American citizenship, through a unique reading constitutional political...
The tumor microenvironment plays a crucial role in both the development and progression of prostate cancer. Furthermore, identifying protein gene expression differences between different regions is valuable for treatment development. We applied Digital Spatial Profiling multiplex analysis to formalin-fixed paraffin embedded prostatectomy tissue blocks investigate transcriptome tumor, tumor-adjacent stroma (TAS), CD45+ TAS tissue. Differential an immunology/oncology panel (n = 58) was...
Endogenous retroviruses (ERVs) are abundant, repetitive elements dispersed across the human genome and implicated in various diseases. We investigated two potential roles for ERVs prostate cancer (PCa). First, PCa of Black Americans (BA) is diagnosed at an earlier median age a more advanced stage than White (WA). used publicly available RNA-seq data from tumor-enriched samples 27 BA 65 WA patients order to identify 12 differentially expressed (padj < 0.1) tissue microarray cores independent...
Efforts are underway to improve the accuracy of non-specialist screening for oral cancer (OC) risk, yet better will only translate into improved outcomes if at-risk individuals comply with specialist referral. Most from low-resource, minority, and underserved (LRMU) populations fail complete a referral OC risk. The goal was evaluate impact novel approach on compliance in positive risk outcome. A total 60 LRMU subjects who had screened increased were recruited given choice an in-person (20...
Abstract Background: Non-Hispanic Black American patients (BA) with prostate cancer (PCa) tend to fare worse than their White counterparts (WA), even consideration of socioeconomic disparities. Clinically, BA face diagnosis at younger age clinical outcomes. Stromal cells adjacent the tumor, including carcinoma-associated fibroblasts (CAFs), play a critical role in tumorigenesis PCa. Dysfunction tumor microenvironment crucial mediating and is emerging as key target for therapy solid tumors....
Cutaneous involvement in multiple myeloma is an extremely rare occurrence that underrecognized and akin CNS involvement, typically occurs late the disease course, associated with aggressive biology. Pathologic examination key to diagnosis a standard of care treatment has not been established for these patients.
Although upfront autologous stem cell transplantation (ASCT) generally improves progression-free survival (PFS) in newly diagnosed multiple myeloma (NDMM), the overall (OS) benefit and optimal timing of ASCT are not well established. Patients with early response may be able to safely continue induction avoid without compromised outcomes. We report an extended follow-up analysis a phase 2 trial that randomized transplant-eligible patients NDMM who responded (50/65 patients) continued or ASCT;...