A5026906324- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Knee injuries and reconstruction techniques
- Genomics and Phylogenetic Studies
- Genital Health and Disease
- Silk-based biomaterials and applications
- Identification and Quantification in Food
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Collagen: Extraction and Characterization
- Cancer Cells and Metastasis
- Dental Implant Techniques and Outcomes
- MicroRNA in disease regulation
- Tendon Structure and Treatment
- Proteoglycans and glycosaminoglycans research
- Aquaculture disease management and microbiota
- Hematopoietic Stem Cell Transplantation
- Tissue Engineering and Regenerative Medicine
- Genetic diversity and population structure
- Lower Extremity Biomechanics and Pathologies
- Reconstructive Surgery and Microvascular Techniques
- Connective tissue disorders research
- Hair Growth and Disorders
University of Malaya
2007-2023
National University of Malaysia
2011
Abstract The use of mesenchymal stem cells (MSCs) for cartilage repair has generated much interest owing to their multipotentiality. However, significant presence in peripheral blood (PB) been a matter debate. objectives this study are isolate and characterize MSCs derived from PB and, compare chondrogenic potential MSC bone marrow (BM). BM 20 patients were isolated characterized. From 2 ml BM, 5.4 ± 0.6 million 10.5 0.8 adherent cells, respectively, obtained by cell cultures at passage 2....
Abstract Chondrogenic differentiated mesenchymal stem cells (CMSCs) have been shown to produce superior chondrogenic expression markers in vitro. However, the use of these vivo has not fully explored. In this study, assessment cartilage repair potential between allogenic‐derived pre‐differentiated and undifferentiated MSCs (MSCs) were compared. Bilateral full thickness defects created on medial femoral condyles 12 rabbits ( n = 12). Rabbits divided into two groups. one group, right knees...
Background: Mesenchymal stem cells (MSCs) represent a promising alternative form of cell-based therapy for cartilage injury. However, the capacity MSCs chondrogenesis has not been fully explored. In particular, there is presently lack studies comparing effectiveness to conventional autologous chondrocyte (autoC) treatment regeneration full-thickness defects in vivo. Hypothesis: Treatment with allogenic undifferentiated (alloMSCs) results superior tissue profiles when compared autoC repair...
Objective Advances in research have shown that the subchondral bone plays an important role propagation of cartilage loss and progression osteoarthritis (OA), but whether changes precede or lead to articular remains debatable. In order elucidate occur early OA, experiment using anterior cruciate ligament transection (ACLT) induced posttraumatic OA model rat knee was conducted. Design Forty-two Sprague Dawley rats were divided into 2 groups: ACLT group nonoperated control group. Surgery...
Abstract Extracellular matrices have drawn attention in tissue engineering as potential biomaterials for scaffold fabrication because of their bioactive components. Noninvasive techniques and cross‐linking treatments are believed to maintain the integrity molecules while providing proper architectural mechanical properties. Cartilage matrix derived scaffolds designed support maintenance chondrocytes provide signals differentiation chondroinducible cells. Chondroinductive bovine articular...
Articular cartilage is a tissue specifically adapted to specific niche with low oxygen tension (hypoxia), and the presence of such conditions key factor in regulating growth survival chondrocytes. Zinc deficiency has been linked cartilage-related disease, known provide antibacterial benefits, which makes its inclusion attractive an vitro system reduce infection. Inclusion 1% zinc oxide nanoparticles (ZnONP) poly octanediol citrate (POC) polymer cultured hypoxia not well determined. In this...
Abstract Most studies highlight mesenchymal stem cells (MSCs) extracted primarily from bone marrow (BM), very few report the use of peripheral blood (PB), often due to associated low seeding density and difficulties with extraction techniques. As ageing populations are becoming more predominant globally, together escalating demands for MSC transplantation tissue regeneration, obtaining quality MSCs suitable induced differentiation biological therapies becomes increasingly important. In this...
In recent years, the potential of cartilage tissue engineering techniques employing mesenchymal stem cells (MSCs) to repair damaged human and defects has generated much interest. Traditionally, sources MSCs included patient’s own bone marrow. However, little have been reported on adult peripheral blood (PB) as a source MSCs, which subject debate amongst scientists owing its extremely low density in PB difficulties associated with extracting from PB. The objectives this study were isolate...