A5100774964- Natural product bioactivities and synthesis
- Osteoarthritis Treatment and Mechanisms
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Cosmology and Gravitation Theories
- Galaxies: Formation, Evolution, Phenomena
- MicroRNA in disease regulation
- Bioactive Compounds in Plants
- Neuroscience and Neuropharmacology Research
- Hydrogen's biological and therapeutic effects
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Adenosine and Purinergic Signaling
- Bioactive natural compounds
- Kruppel-like factors research
- PARP inhibition in cancer therapy
- Natural Compound Pharmacology Studies
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Cell death mechanisms and regulation
- Sirtuins and Resveratrol in Medicine
- Hops Chemistry and Applications
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2024
Wenzhou Medical University
2016-2024
Southwest University
2024
Nanjing Drum Tower Hospital
2024
Southern University of Science and Technology
2019
University of Nottingham
2000-2007
Chinese Academy of Sciences
2007
State Street (United States)
2004
University of Mississippi Medical Center
2004
Shandong Agricultural University
1997
Abstract Osteoarthritis (OA) is a complex condition that involves both apoptosis and senescence currently cannot be cured. Fibroblast growth factor 21 (FGF21), known for its role as potent regulator of glucose energy metabolism, protects from various diseases, possibly by mediating autophagy. In the present study, FGF21 in progression OA was investigated vitro vivo experiments. vitro, results revealed administration alleviated apoptosis, senescence, extracellular matrix (ECM) catabolism...
Abstract Glioblastoma, IDH-Wild type (GBM, CNS WHO Grade 4) is a highly heterogeneous and aggressive primary malignant brain tumor with high morbidity, mortality, poor patient prognosis. The global burden of GBM increasing notably due to limited treatment options, drug delivery problems, the lack characteristic molecular targets. OTU deubiquitinase 4 (OTUD4) potential predictive factor for several cancers such as breast cancer, liver lung cancer. However, its function in remains unknown. In...
Osteoarthritis (OA), a progressive joint disorder, is principally characterized by the degeneration and destruction of articular cartilage. Ellagic acid (EA), natural polyphenol found in berries nuts has shown potent anti-inflammatory effects, however, its effects underlying mechanisms on OA have seldom been systematically illuminated. In this study, we reported (EA) progression both vitro vivo experiments. IL-1β-induced expression inducible nitric oxide synthase (iNOS), cyclooxygenase-2...
Osteoarthritis (OA), a common degenerative joint disease, is principally characterized by inflammation and destruction of cartilage. Nobiletin, an extract the peel citrus fruits, known to have anti-inflammatory properties. However, mechanisms which nobiletin plays protective role in osteoarthritis (OA) are not completely understood. In present study, we investigated effects progression OA both vitro vivo experiments. Mouse chondrocytes were pretreated with (0, 10, 20, 40 μM) for 24 h then...
Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly targets the synovial membrane, thus causing stiffness, deformity and dysfunction of joints. To date, no effective anti‑inflammatory treatments are available for RA. Piceatannol (PIC) natural derivative resveratrol, which has been reported to attenuate response. evaluate effect PIC on RA determine underlying molecular target PIC, both in vitro vivo experiments were performed present study. A CIA rat model was established...
Background: Osteoarthritis (OA) is a very common condition and leads to joint pain, disability, price tag all over the world. Pathogenesis of OA closely related numerous inflammatory apoptosis cytokines. Hydrogen (H 2 ) reportedly exhibits diversity effects such as anti-apoptotic, anti-inflammatory, anti-oxidative properties via JNK pathway. However, it unknown whether H has protective effect against signaling Therefore, aim this study was figure out hydrogen on chondrocyte further explore...
Osteoarthritis (OA) is a frequently observed condition in aged people. OA cartilage characterized by chondrocyte apoptosis, inflammation, and hyperactive catabolism of extracellular matrix. However, the specific molecular mechanisms remain unclear. Recent data has shown that Angptl4, multifunctional cytokine, involved regulation inflammatory apoptosis responses different tissues. This study aimed at defining role Angptl4 development OA. We employed X-ray analysis, safranin O-fast green (S-O)...
We investigate the behaviour of galaxy clustering on large scales using PSCz catalogue. In particular, we ask whether there is any evidence large-scale fractal in this find correlation dimension survey varies with scale, consistent other analyses. For example, our results small and intermediate are those obtained from QDOT sample, but larger sample allows us to extend analysis out much scales. firm that becomes homogeneous at scales; D2=2.992±0.003 for r>30 h−1 Mpc. This provides strong...
Recent studies have underscored the cardioprotective properties of liraglutide. This research explores its impact on cardiac hypertrophy and heart failure following transverse aortic constriction (TAC). We found that liraglutide administration markedly ameliorated hypertrophy, fibrosis, function. These benefits correlated with increased ANP expression reduced activity in calcineurin A/NFATc3 signaling pathway. Moreover, mitigated ER stress cardiomyocyte apoptosis, enhanced autophagy....
Scale transformations have played an extremely successful role in studies of cosmological large-scale structure by relating the non-linear spectrum density fluctuations to linear primordial power at longer wavelengths. Here we generalize this approach investigate usefulness scale for nonlinear higher-order statistics, specifically bispectrum. We find that bispectrum predicted perturbation theory tree-level can be rescaled match results full numerical simulations weakly and intermediately...
The present study assessed the mechanism by which resveratrol (Res) inhibits growth of SW1353 chondrosarcoma cells and examined whether sirtuin 1 (Sirt1) activation affects phosphorylation within signal transduction activator transcription 3 (STAT3) signaling pathway. used in logarithmic phase (control treatment groups). latter group was treated with Res at 25 50 µmol/l for 24 h, cell viability, proliferation apoptosis were analyzed using counting kit‑8 assay, colony Hoechst staining,...
Background: Hyperactivity of the mechanistic target rapamycin complex 1 (mTORC1) is implicated in a variety diseases such as cancer and diabetes. Treatment may benefit from effective mTORC1 inhibition, which can be achieved by preventing arginine disrupting cytosolic sensor for subunit (CASTOR1)–GTPase-activating proteins toward RAGS subcomplex 2 (GATOR2) through binding with CASTOR1. An attractive idea to determine analogues that are competent CASTOR1, but without CASTOR1–GATOR2...
The present study aimed to see if 20-Deoxyingenol(20-DOI) could protect hippocampus neurons from the neurotoxic effects of morphine and reduce memory loss in rats.
Background: Gastric cancer is the most common gastrointestinal malignancy with an increasing incidence rate worldwide. Finding novel curative and preventive approaches that could target tumor cells without affecting normal overcome drug resistance will be tremendously useful. Objectives: This study aimed to evaluate effects of quercetin (QUE) in combination doxorubicin (DOX) on apoptosis its underlying mechanisms KATO III gastric cell line. Methods: The Que DOX viability were measured using...