A5081010577- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Nanoparticles: synthesis and applications
- Computational Drug Discovery Methods
- Medicinal Plants and Neuroprotection
- Heavy Metal Exposure and Toxicity
- Pharmacological Effects of Natural Compounds
- Moringa oleifera research and applications
- Cholinesterase and Neurodegenerative Diseases
- Bee Products Chemical Analysis
- Seed and Plant Biochemistry
- Plant Toxicity and Pharmacological Properties
- Diabetes Treatment and Management
- Phytochemicals and Medicinal Plants
- Nanocomposite Films for Food Packaging
- Research on Leishmaniasis Studies
- Free Radicals and Antioxidants
- Water Quality and Pollution Assessment
- Pharmacology and Obesity Treatment
- Curcumin's Biomedical Applications
- Mangiferin and Mango Extracts
- Natural product bioactivities and synthesis
- Phytochemistry and Bioactivity Studies
- Bioactive Natural Diterpenoids Research
Afe Babalola University
2017-2024
The phenolic extract of Senecio biafrae leaves was investigated to determine the in vitro antioxidant, profiles, and inhibition key enzymes relevant type II diabetes mellitus (α-amylase α-glucosidase) Alzheimer's disease (acetylcholinesterase butrylcholinesterase). demonstrated significant scavenging abilities against all antioxidant parameters assessed. Reversed-phase HPLC revealed presence gallic acid, chlorogenic, caffeic rutin, quercetin, kaempferol. also inhibited activities α-amylase...
Currently, there is no known cure for diabetes. Different pharmaceutical therapies have been approved the management of type 2 diabetes mellitus (T2DM), some are in clinical trials and they classified according to their route or mechanism action. Insulin types, sulfonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones, meglitinides, sodium–glucose cotransporter incretin-dependent (glucagon-like peptide-1 receptor agonists: GLP-1R, dipeptidyl peptidase 4 inhibitors: DPP-4)....
In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection alloxan (150 mg/kg body weight) female Wistar rats. The orally administered with 400 free phenol, bound 5 metformin, respectively. On the 14th day oral administration, animals sacrificed, assessed. Fasting blood glucose glycated hemoglobin levels; homeostasis model...
Abstract Background Recent reports have highlighted the significance of plant bioactive components in drug development targeting neurodegenerative disorders such as Alzheimer’s disease (AD). Thus, current study assessed antioxidant activity and enzyme inhibitory aqueous extract Talinum triangulare leave (AETt) well molecular docking/simulation identified phytonutrients against human cholinesterase activities. Methods In vitro assays were carried out to assess 2,2- azinobis...
Plants possess compounds serving as reducing agents for green synthesis of gold nanoparticles (AuNPs), which is currently considered biomedical application. Exposure to cadmium (Cd) can affect the functional integrity several organs such kidney and liver. Nymphaea lotus (NL) known its medicinal properties, including protective role against tissue damages. This study investigated bioactive in NL using gas chromatography-mass spectroscopy (GC-MS) ameliorative potential biosynthesized AuNPs...
The burden of human schistosomiasis, a known but neglected tropical disease in Sub-Saharan Africa, has been worrisome recent years. It is becoming increasingly difficult to tackle schistosomiasis with praziquantel, drug be effective against all Schistosoma species, due reports reduced efficacy and resistance. Therefore, this study seeks investigate the antischistosomal potential phytochemicals from Azadirachta indica proteins that have implicated as druggable targets for treatment using...
Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or resistance. As result, there growing interest in exploring natural alternatives for the treatment and prevention of diabetes. Gossypium herbaceum has been traditionally used various traditional medicine systems, including Ayurveda, its therapeutic benefits. Therefore, aim this study was evaluate vitro antioxidant potentials, antidiabetic neuroprotective...
Bryophyllum pinnatum (Lam.) Oken leaves are employed as food and traditional medicines. This study investigates the antioxidant activity (reducing power, DPPH, ABTS, FRAP, H2O2 scavenging ability metal ion chelating), carbohydrate digesting enzymes inhibitory of cholinergic enzyme aqueous extract fractions (n-hexane, ethyl acetate, n-butanol, residual fraction) B. were investigated. Results showed that exhibited DPPH radical abilities, iron chelation, hydrogen peroxide abilities reducing...
Medicinal plants are widely utilised by the African population since they have no harmful side effects and low cost compared with different treatments. The field of nanotechnology is most active part research in modern material's science. Though there several chemicals as well physical methods, however, green synthesis nanomaterials emerging method synthesis. Conventionally, chemical reduction often applied approach for preparation metallic nanoparticle's protocols it cannot avoid...
Jatropha tanjorensis leaves were collected, air dried and pulverised. The pulverised sample was extracted with solvents (n-hexane, ethylacetate ethanol) of varying polarity to obtain the crude extracts.Repeated column thin layer chromatographic separation extracts afforded two compounds which characterised by their IR, MS, 1H 13C-NMR spectral data. Comparison data withliterature confirmed be taraxerol taraxer-14-en-3-one.
Plant phytonutrients have been harnessed for their various curative properties both in vitro and vivo. In this study African black velvet tamarind (ABVT) fruit pulp was evaluated it antioxidant potentials using chloroform hexane fractions through different parameters. the results; total phenolic contents quantified mg GAE/dried sample extracts were; 14.57 ±5.85 9.78 ±4.61, flavonoid as; 48.58 ±0.00 27.35 while FRAP (µg AAE.g-1 dried sample) lower (298.10 ±0.00) than (1029.81 ±0.00). More...
Introduction: Moringa oleifera is a drought-resistant plant, widely used in the tropical region. The leaves and stems have been extensively utilised foods neutraceuticals preparation, with less attention to seeds. In this study, amino acid (AA) compositions of M. testa cotyledon were examined comparatively. Methods: Samples separately defatted, hydrolyed, neutralised. AA solution was purified by cation-exchange solid-phase extraction, derivatised analysed gas chromatography. Results:...
Organic pollutants are that organic in nature, basically containing carbon covalently bonded with other elements. They known to be toxic or carcinogenic nature. Their presence water large quantity causes considerable and widespread concern. Ten samples -sachets bottles, were bought from different potable producing plants Ado-Ekiti environs. By using a separatory funnel liquid-liquid extraction system of 50mL:50mL n-Hexane: Dichloromethane, contaminants extracted the samples. These analyzed...