The use of plant and products in the synthesis silver nanoparticles (AgNPs) gold (AuNPs) is made possible because natural inherent phytochemicals responsible for reduction respective metallic salts to nanoparticle forms, ensuring therapeutic applicability. In this study, AgNPs AuNPs was performed using two different aqueous extraction methods Crassocephalum rubens: maceration laboratory method (cold extract rubens (AECR)), decoction traditional healer's (hot crude (CECR)). synthesized were...

Alzheimer's disease (AD) is a major health challenge worldwide, especially among the elderly. The associated with cognitive and memory deficits. This study investigated effect of Hibiscus sabdariffa synthesized-gold nanoparticles (HS-AuNPs) on AlCl3-induced deficits in rats. Forty-two male Wistar rats were divided into six groups (n = 7). Group I served as control. Rats group II - V exposed to AlCl3 (100 mg/kg) induce AD. III treated 5 mg/kg donepezil, 10 HS-AuNPs, respectively, for 14 days....

Plants possess compounds serving as reducing agents for green synthesis of gold nanoparticles (AuNPs), which is currently considered biomedical application. Exposure to cadmium (Cd) can affect the functional integrity several organs such kidney and liver. Nymphaea lotus (NL) known its medicinal properties, including protective role against tissue damages. This study investigated bioactive in NL using gas chromatography-mass spectroscopy (GC-MS) ameliorative potential biosynthesized AuNPs...

Protein hydrolysates from dietary sources possess many physiological and biological properties. Artocarpus altilis is an evergreen multipurpose plant with benefits. Therefore, this study evaluates in vitro antioxidant anti-inflammatory properties of A. protein hydrolysates. was isolated hydrolysed pepsin trypsin separately using different enzyme: substrate ratios (1:8, 1:16, 1:32). Antioxidant investigated included Fe2+-chelating, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical hydrogen...

The development of cancer therapies has become difficult due to high metastasis, and lack tissue selectivity, which in most cases affects normal cells. Demand for anticancer therapy is therefore increasing on daily basis. Gold nanoparticles (AuNPs) have many applications biomedical field. Biological synthesis AuNPs using aqueous extract Crassocephalum rubens (AECR) was designed investigate the vitro potential. synthesized were characterized by UV-vis spectroscopy, high-resolution...

Abstract The development of gold nanoparticles (AuNPs) using a green approach has drawn considerable interest in the field nanomedicine. Its wide application clinical diagnosis, imaging and therapeutics portrays its importance for human existence. In this study, we reported on biogenic synthesis AuNPs aqueous extract Xylopia aethiopica fruit (AEXAf), which acts as both reducing stabilizing agent. characterization AEXAf-AuNPs was performed ultraviolet-visible spectroscopy, dynamic light...

Abstract Background Short-term memory impairment is a neurodegenerative disease associated with oxidative stress. Bryophyllum pinnatum (Lam.) Oken of the family Crassulaceae traditionally used in treatment diseases, such as cough, wounds, and kidney diseases. This study evaluates effect aqueous extract B. (AEBP) leaves on acetylcholinesterase activity carbon tetrachloride (CCl 4 )-induced short-term rats. Methods Thirty male Wistar albino rats were this divided into six groups (n=5). Group I...

Objective: Antioxidants are known to offer resistance against oxidative stress by scavenging free radicals, inhibiting lipid peroxidation and other mechanisms. They therefore help in preventing the radicals induced diseases. Solanum macrocarpon is an important medicinal plant with rich source of nutritional constituents. The objective present study was investigate ability S.macrocarpon leaves protect tissues iron (Fe2+)-induced rat’s liver brain. Methods: total phenolic flavonoid contents...

Gallic acid (GA) is a polyphenolic substance which can be sourced naturally from plant sources and also synthesized industrially. In-depth study on GA in recent years has revealed that it powerful anti-inflammatory antioxidant properties. In many disease models, been found to ameliorate oxidative stress, inflammation resultant damage. The neuroprotective properties of against numerous animal models neurodegenerative disorders have outlined by number vivo investigations. However, this present...

Aluminum toxicity has become a reason for concern in recent times. This study aimed to evaluate the protective effect of hesperidin and gallic acid aluminum chloride (AlCl3)-induced nephrotoxicity rats. Thirty Wistar rats were randomly divided into six groups five animals apiece. Group one served as control received distilled water while lasted. Animals 2-4 AlCl3 (100 mg/kg/day) throughout study. 3 4 administered 100 mg/kg/day hesperidin, respectively, addition AlCl3. Groups 5 6 treated with...

BACKGROUND: The prevalence of diabetes mellitus continues to increase alarmingly in spite years intensive research. need explore alternative therapy such dietary and phytotherapy has been gaining attention the management/treatment mellitus. OBJECTIVE: present research work was carried out investigate biochemical indices liver kidney alloxan-induced diabetic rats fed with Artocarpus altilis fruit based-diet. METHODS: Diabetes induced by a single intraperitoneal injection alloxan (150 mg/kg)...

Abstract Buchholzia coriacea is known for its anti-oxidative, anti-inflammatory, and anti-diabetic properties. This study evaluated the effect of alkaloid-rich extract seed (ArEBCs) against copper-induced toxicity in Drosophila melanogaster . The flies were exposed to graded doses (25 200 mg/kg diet) ArEBCs 12 days thereafter, a survival test was carried out determine safe therapeutic used ameliorative study. For this, CuSO 4 (1 mM) alone or combination with 50 5 days. Locomotor activity...

Cadmium (Cd) exposure induces kidney damage by mediating oxidative stress and inflammation. In this study, the role of Crassocephalum rubens-gold nanoparticles (C. rubens-AuNPs) in down-regulating injury molecules-1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL) genes inhibiting Cd-induced rats was investigated. Thirty male Wistar were distributed randomly into six groups (n = 5). Group I served as control, while II, III, IV, V administered with 20 mg/kg b.w. cadmium chloride...

Cadmium (Cd) is an industrial heavy metal that causes toxic effects to several body organs including the kidney. Medicinal plants are used in managing various diseases caused by environmental toxicants. This study aimed evaluate protective ability of Mondia whitei fruit extract (MWE) against nephrotoxicity induced CdCl₂ exposure Wistar rats. Twenty-five male rats 90 130 g weight (b.w) were this study. The animals indiscriminately assigned five groups per group. control group I, whereas II V...

Introduction: Mondia whitei (Hook.f.) Skeels is rich in antioxidant activity and known for its nutritional medicinal uses. This study evaluated the protective effect of M. fruit against cadmium-induced hepatic damage rats. Methods: Twenty-five albino (Wistar strain) rats were randomly assigned into five equal groups. Rats group I served as control, II intoxicated with 5 mg/kg body weight (b.w.) cadmium chloride (CdCl2 ) days via an oral route, while groups III, IV, V respectively...

The current study explored various antioxidant properties and HPLC-DAD analysis of ethylacetate aqueous extracts from Talinum triangulare (T. triangulare) as well their inhibitory potentials on exzymatic activities implicated in type II diabetes. In this study, quantification total abilities revealed that T. had 11.52 ± 0.78 2.46 0.26 mg (AAE/g), respectively. However, both showed metal-chelating ability but extract higher inhibition against Fe2+ (IC50 = 0.50 0.01 mg/ml) than 0.57 mg/ml)....