A5069068963- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Mobile Health and mHealth Applications
- Electronic Health Records Systems
- Health Literacy and Information Accessibility
- Food Security and Health in Diverse Populations
- Adolescent and Pediatric Healthcare
- Prenatal Screening and Diagnostics
- Biomedical Text Mining and Ontologies
- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- HIV/AIDS Research and Interventions
- Health disparities and outcomes
- Chronic Disease Management Strategies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ethics in Clinical Research
- Platelet Disorders and Treatments
- Religion, Spirituality, and Psychology
- Healthcare Systems and Technology
- Child and Adolescent Health
- Data Quality and Management
- Health, Environment, Cognitive Aging
- Machine Learning in Healthcare
- Diabetes Management and Education
The Ohio State University
2007-2025
Vanderbilt University
2013-2024
Nationwide Children's Hospital
2023
The Ohio State University Wexner Medical Center
2021-2023
Vanderbilt University Medical Center
2015-2022
Valley Health System
2015
Jessop Hospital
2012
Pediatrics and Genetics
2010
Mayo Clinic
1972
Board of Cooperative Educational Services of Nassau County
1970
Abstract Objective To evaluate the phenotyping performance of three major electronic health record (EHR) components: International Classification Disease (ICD) diagnosis codes, primary notes, and specific medications. Materials Methods We conducted evaluation using de-identified Vanderbilt EHR data. preselected ten diseases: atrial fibrillation, Alzheimer’s disease, breast cancer, gout, human immunodeficiency virus infection, multiple sclerosis, Parkinson’s rheumatoid arthritis, types 1 2...
The
To create a computable MEDication Indication resource (MEDI) to support primary and secondary use of electronic medical records (EMRs).
Understanding how to identify the social determinants of health from electronic records (EHRs) could provide important insights understand or disease outcomes. We developed a methodology capture 2 rare and severe health, homelessness adverse childhood experiences (ACEs), large EHR repository.We first constructed lexicons ACE phenotypic profiles. employed word2vec lexical associations mine homelessness-related words. Next, using relevance feedback, we refined profiles with iterative searches...
Objective: Phenotyping algorithms applied to electronic health record (EHR) data enable investigators identify large cohorts for clinical and genomic research. Algorithm development is often iterative, depends on fallible investigator intuition, time- labor-intensive. We developed evaluated 4 types of phenotyping categories EHR information hypertensive individuals controls provide a portable module implementation at other sites. Materials Methods: reviewed the EHRs 631 followed Vanderbilt...
Abstract To accelerate medical breakthroughs, the All of Us Research Program aims to collect data from over one million participants. This report outlines processes used construct Social Determinants Health (SDOH) survey and presents psychometric characteristics SDOH measures in . A consensus process was select measures, prioritizing concepts validated diverse populations other national cohort surveys. Survey item non-response calculated, Cronbach’s alpha analyze properties scales....
Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional as well identifying novel associations. Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of variants the fat mass and obesity associated gene (FTO), some which been previously with type 2 diabetes (T2D). We a population 10,487 individuals European ancestry genome-wide genotyping Electronic Medical Records Genomics (eMERGE) Network...
Objective: Hospital admissions are significant events in the care of individuals with sickle cell disease (SCD) due to associated costs and potential for quality life compromise.Methods: This cross-sectional cohort study evaluated risk factors readmissions between October 2014 March 2016 adults SCD (n = 201) caregivers children 330) at six centres across U.S. Survey items assessed social determinants health (e.g. educational attainment, difficulty paying bills), depressive symptoms, support,...
The All of Us Research Program is building a national longitudinal cohort and collecting data from multiple information sources (e.g., biospecimens, electronic health records, mobile/wearable technologies) to advance precision medicine. Participant-provided information, collected via surveys, will complement augment these sources. We report the process used develop refine initial three surveys for this program.The survey development included: (1) prioritization domains scientific needs, (2)...
Summary Heparin-induced thrombocytopenia (HIT) is an unpredictable, potentially catastrophic adverse effect of heparin treatment resulting from immune response to platelet factor 4 (PF4)/heparin complexes. No genome-wide evaluations have been performed identify potential genetic influences on HIT. Here, we a association study (GWAS) and candidate gene using HIT cases controls identified electronic medical records (EMRs) coupled DNA biobank attempted replicate GWAS associations in independent...
Patient portal adoption has increased over the last two decades. Most research about patient portals focused on adult populations in primary care and medical specialty settings.We describe initial long-term use by pediatric patients their caregivers a broadly deployed at an academic center.We analyzed usage for from 2008 to 2014. We recorded events with time stamps; user role defined as self, surrogate (i.e., parent or guardian), delegate; functions accessed. Usage were grouped into sessions...
Abstract Objective Hospital-acquired acute kidney injury (HA-AKI) is a potentially preventable cause of morbidity and mortality. Identifying high-risk patients prior to the onset key step towards AKI prevention. Materials Methods A national retrospective cohort 1,620,898 patient hospitalizations from 116 Veterans Affairs hospitals was assembled electronic health record (EHR) data collected 2003 2012. HA-AKI defined at stage 1+, 2+, dialysis. EHR-based predictors were identified through...
To determine whether assisted annotation using interactive training can reduce the time required to annotate a clinical document corpus without introducing bias.A tool, RapTAT, was designed assist by iteratively pre-annotating probable phrases of interest within document, presenting annotations reviewer for correction, and then corrected further machine learning-based before subsequent documents. Annotators reviewed 404 notes either manually or RapTAT assistance concepts related quality care...
A participant's medical history is important in clinical research and can be captured from electronic health records (EHRs) self-reported surveys. Both incomplete, EHR due to documentation gaps or lack of interoperability surveys recall bias limited literacy. This analysis compares collected the All Us Research Program through both EHRs.
Abstract In response to the rapidly evolving coronavirus disease 2019 (COVID-19) pandemic, All of Us Research Program longitudinal cohort study developed COVID-19 Participant Experience (COPE) survey better understand pandemic experiences and health impacts on diverse populations within United States. Six versions were deployed between May 2020 March 2021, covering mental health, loneliness, activity, substance use, discrimination, as well symptoms, testing, treatment, vaccination. A total...
Depressive symptoms are prevalent in individuals living with sickle cell disease (SCD) and may exacerbate pain. This study examines whether higher depressive associated pain outcomes, catastrophizing, interference potential opioid misuse a large cohort of adults SCD. The utilized baseline data from the 'CaRISMA' trial, which involved 357 SCD chronic Baseline assessments included intensity, daily mood, Patient Health Questionnaire (PHQ), Generalized Anxiety Disorders scale, PROMIS Pain...