A5011252897- Biofuel production and bioconversion
- Microbial Natural Products and Biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Production and Characterization
- Enzyme Catalysis and Immobilization
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Insect Resistance and Genetics
- Horticultural and Viticultural Research
- RNA modifications and cancer
- Microbial Metabolites in Food Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- Antifungal resistance and susceptibility
- Pharmacological Effects of Natural Compounds
- Plant nutrient uptake and metabolism
- Marine Sponges and Natural Products
- Plant Gene Expression Analysis
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Phytase and its Applications
- Legume Nitrogen Fixing Symbiosis
- Chromosomal and Genetic Variations
- Fungal Biology and Applications
- Plant-Microbe Interactions and Immunity
- RNA and protein synthesis mechanisms
Northwest A&F University
2014-2024
Zhengzhou Fruit Research Institute
2023
Chinese Academy of Agricultural Sciences
2018-2023
Hubei University of Technology
2021-2023
Hong Kong University of Science and Technology
2018-2021
University of Hong Kong
2018-2021
Shenzhen Institutes of Advanced Technology
2021
Binzhou University
2020
Binzhou Medical University
2020
Jiangnan University
2016-2020
The aim of this study was to investigate how dietary supplementation tea polyphenols (TP) and catechins (TC) affect laying performance, albumen quality, ovomucin composition, magnum morphology hens in the late phase production. Two hundred seventy Hy-Line Brown (64 wk old) were assigned a basal diet (the control), supplemented with 200 mg/kg (TP200) or (TC200). Each treatment had 6 replicates 15 each. feeding trial lasted 10 wks. Over course trial, TP200 significantly increased egg...
The balance between saturated and unsaturated fatty acids plays a crucial role in determining the membrane fluidity. In diploid fungal pathogen <i>Candida albicans</i>, gene for acid Δ9 desaturase, <i>OLE1</i>, is essential viability. Using reverse genetic approach, termed fitness test, we identified group of structurally related synthetic compounds that induce specific hypersensitivity <i>OLE1</i><sup>+/−</sup> strain. Genetic repression <i>OLE1</i> chemical inhibition by two selected...
Despite that considerable efforts have been devoted to the design of various fluorogenic enzyme substrates, they are single-enzyme assay approaches cannot afford detection multienzyme activity. In this study, we set out our first attempt a new probe could measure intracellular β-d-glucosidase and phosphodiesterase I activities. Unlike commonly used substrates contain one recognition site signaling reporter, molecule possesses two cleavage sites, specificly corresponding I, three fluorescent...
Allelopathy is closely associated with rhizosphere biological processes, and microbial communities are essential for plant development. However, our understanding of rhizobacterial under influence allelochemicals in licorice remains limited. In the present study, responses effects on allelopathy were investigated using a combination multi-omics sequencing pot experiments, allelochemical addition inoculation treatments.
Protein–polymer conjugation is a clinically validated approach to enhanced pharmacokinetic properties. However, the permanent attachment of polymers often leads irreversibly reduced protein bioactivity and poor tissue penetration. As such, use protein–polymer conjugates for solid tumors remains elusive. Herein, we report simple strategy using enzyme-activatable size-shrinkable protein–polypeptide overcome this clinical challenge. Briefly, matrix metalloproteinase (MMP)-responsive peptide...
Interactions between plant hosts and their microbiotas are becoming increasingly evident, while the effects of communities on microbial in different geographic environments poorly understood. Here, differentiation licorice ecotypes distribution root-associated were investigated across five sampling sites northwest China. The interactions environment, communities, root secondary metabolites, elucidated. community was clearly differentiated into distinct based genotyping-by-sequencing...
Background: Epigallocatechin-3-gallate (EGCG), which is the principal component of green tea, has been shown to prevent atherosclerosis. However, effect EGCG on atherosclerotic plaque stability remains unknown. Aim: This study aimed assess whether can enhance and investigate underlying mechanisms. Methods: Apolipoprotein E-deficient mice fed a high-fat diet were injected intraperitoneally with (10 mg/kg) for 16 weeks. Cross sections brachiocephalic arteries stained haematoxylin eosin...
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Oenococcus oeni plays a key role in inducing malolactic fermentation wine. Acid stress is often encountered under wine conditions. However, the lack of systematic studies acid resistance mechanisms limits downstream applications. In this study, responses O. were investigated by combining transcriptome, metabolome, and genome-scale metabolic modeling approaches. Metabolite profiling highlighted decreased abundance nucleotides stress. The gene-metabolite bipartite network showed negative...
The molecular evolutionary dynamics that shape hantaviruses’ evolution are poorly understood even now, besides the contribution of virus-host interaction to their remains an open question. Our study aimed investigate these two aspects in Hantaan virus (HTNV)—the prototype hantaviruses and emerging zoonotic pathogen infects humans, causing hemorrhagic fever with renal syndrome (HFRS): endemic Far East Russia, China, South Korea—via a comprehensive, phylogenetic-dependent codon usage analysis....
Telomeres are regions of tandem repeated sequences at the ends linear chromosomes that protect against DNA damage and chromosome fusion. associated with senescence cancers have attracted attention an increasing number researchers. However, few telomeric motif known. Given mounting interest in telomeres, efficient computational tool for
The endophytic fungus Aspergillus aculeatus isolated from leaves of the papaya plant Carica was fermented on solid rice medium, yielding a new l-tryptophan-l-phenyllactic acid conjugate (1) and thirteen known compounds (11, 14-25). In addition, an OSMAC approach employed by adding eight different sodium or ammonium salts to medium. Addition 3.5% NaNO3 caused significant change metabolite pattern as indicated HPLC analysis. Subsequent isolation yielded several substituted conjugates (1-10) in...
We describe our optimization efforts to improve the physicochemical properties, solubility, and off-target profile of 1, an inhibitor TarO, early stage enzyme in biosynthetic pathway for wall teichoic acid (WTA) synthesis. Compound 1 displayed a TarO IC50 125 nM assay possessed very high lipophilicity (clogP = 7.1) with no measurable solubility PBS buffer. Structure-activity relationship (SAR) studies resulted series compounds improved lipophilic ligand efficiency (LLE) consistent reduction...