A5077593953- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Pregnancy and Medication Impact
- Organ and Tissue Transplantation Research
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- Hematopoietic Stem Cell Transplantation
University of Chicago
2021-2023
Immunological tolerance to semiallogeneic fetuses is necessary achieving successful first pregnancy and permitting subsequent pregnancies with the same father. Paradoxically, an important cause of sensitization, resulting in accelerated rejection offspring-matched allografts. The underlying basis for divergent outcomes following reencounter alloantigens on transplanted organs versus postpartum females incompletely understood. Using a mouse model that allows concurrent tracking endogenous...
The current paradigm indicates that naive T cells are primed in secondary lymphoid organs. Here, we present evidence intranasal administration of peptide antigens appended to nanofibers primes CD8+ the lung independently and prior priming draining mediastinal lymph node (MLN). Notably, comparable accumulation transcriptomic responses MLN observed both Batf3KO wild-type (WT) mice, indicating that, while cDC1 dendritic (DCs) major subset for cross-presentation, cDC2 DCs alone capable...
Alloreactive memory, unlike naïve, CD8+ T cells resist transplantation tolerance protocols and are a critical barrier to long-term graft acceptance in the clinic. We here show that semi-allogeneic pregnancy successfully reprogrammed memory fetus/graft-specific (TFGS) towards hypofunction. Female C57BL/6 mice harboring generated by rejection of BALB/c skin grafts then mated with males achieved rates comparable naive controls. Post-partum from skin-sensitized dams upregulated expression cell...
Dominant infectious tolerance explains how brief tolerance-inducing therapies result in lifelong to donor antigens and "linked" third-party antigens, while recipient sensitization ensuing immunological memory prevent the successful induction of transplant tolerance. In this study, we juxtapose these 2 concepts test whether mechanisms dominant can control a limited repertoire T B cells. We show that single antigen is sufficient stable tolerance, rendering it unstable. Mechanistic studies...
Abstract Alloreactive memory T cells, unlike naive fail to be restrained by transplantation tolerance protocols or regulatory and therefore represent a critical barrier long-term graft acceptance. Using female mice sensitized rejection of fully-mismatched paternal skin allografts, we show that subsequent semi-allogeneic pregnancy successfully reprograms fetus/graft-specific CD8+ cells (T FGS ) towards hypofunction in manner is mechanistically distinct from . Post-partum TFGS were durably...
Abstract Pregnancy is an immunological paradox, where the maternal immune system develops tolerance to a semi-allogeneic fetus, yet pregnancy major sensitizing event in clinical transplantation. We previously reported that robustly tolerizes fetus-specific T cells, allowing for spontaneous acceptance of fetus-matched allografts when B cells and alloantibodies are absent at time transplantation(1). In this study, we report mice sensitized 2WOVA.B/c allogeneic skin grafts (Memory) underwent...