A5016289919- Trace Elements in Health
- Iron Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hemoglobinopathies and Related Disorders
- Folate and B Vitamins Research
- RNA regulation and disease
- Selenium in Biological Systems
- Neurological diseases and metabolism
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Radiopharmaceutical Chemistry and Applications
- RNA and protein synthesis mechanisms
- Prion Diseases and Protein Misfolding
- Liver Diseases and Immunity
- Plant Micronutrient Interactions and Effects
- Systemic Lupus Erythematosus Research
- Heavy Metal Exposure and Toxicity
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and genetic disorders
- Glycosylation and Glycoproteins Research
- Pharmacological Effects of Natural Compounds
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
Innsbruck Medical University
2019-2025
Universität Innsbruck
2020-2025
Christian Doppler Laboratory for Thermoelectricity
2024
VASCage
2022
Christian Doppler Klinik
2022
University Hospital Innsbruck
2020
Bulevirtide (BLV) blocks the uptake of hepatitis D virus (HDV) into hepatocytes via sodium/bile acid cotransporter NTCP. BLV was conditionally approved by EMA but real-life data on efficacy are limited.Patients were treated with monotherapy. Patients who did not achieve further decreases in HDV-RNA after 24 weeks offered PEG-IFN as an add-on therapy a response-guided manner.Twenty-three patients (m: 10, f: 13; mean age: 47.9 years, cirrhosis: 16; median ALT: 71 IU/ml; HDV-RNA: 2.1 × 105...
Abstract Background and Aims Haemochromatosis is characterized by progressive iron overload affecting the liver can cause cirrhosis hepatocellular carcinoma. Most haemochromatosis patients are homozygous for p.C282Y in HFE , but only a minority of individuals with this genotype will develop disease. The aim was to assess penetrance overload, fibrosis, carcinoma life expectancy. Methods A total 8839 from Austrian region Tyrol were genotyped variant between 1997 2021. Demographic, laboratory...
Patients with Crohn's disease are at increased risk for symptomatic nephrolithiasis. Stones in these patients most commonly composed of calcium oxalate monohydrate or mixed calcium-oxalate and calcium-phosphate. Precipitation both minerals depends on urinary pH, calcium, phosphate excretion. The present manuscript reports two bowel resection, whom the onset urolithiasis occurred after repeated infusions ferric carboxymaltose - a drug, which is known to cause hyperphosphaturia. study shows...
Abstract Background Determination of the functional liver mass is important in a variety clinical settings including surgery and transplantation. [ 99m Tc]Tc-diethylenetriamine-pentaacetic acid galactosyl human serum albumin ( Tc-GSA) radiotracer targeting asialoglycoprotein receptor (ASGR) routinely used Japan for this purpose. Here we describe development evaluation 68 Ga]Ga-NODAGA-TriGalactan low molecular weight PET-tracer structure. Results For synthesis TRIS as branching unit NODAGA...
Background/Objectives: MVI is a relevant prognostic factor among patients with hepatocellular carcinoma (HCC) receiving liver transplantation (LT). The preoperative assessment of the risk for to pre-LT patient management and selection. objective this study was create validate model predict microvascular invasion (MVI) based on variables in LT setting. Methods: A total 2170 from 11 collaborative centers Europe, Asia, US, who received transplants between 1 January 2000 31 December 2017, were...
Abstract Wilson disease (WD) is caused by biallelic pathogenic variants in adenosine triphosphatase copper‐transporting beta (ATP7B); however, genetic testing identifies only one or no ATP7B variant a number of patients with WD. Synonymous single‐nucleotide sequence have been recognized as individual families. The aim the present study was to evaluate prevalence and mechanism synonymous c.2292C>T (p.Phe764=) A cohort 280 WD heterozygous for single investigated presence (p.Phe764=). In...
Clinical presentation of Wilson disease (WD) includes hepatic and neurologic manifestations. This study compares subcortical brain regions by magnetic resonance imaging in patients with WD without neurological symptoms. Distinct atrophy affecting the basal ganglia, accumbens, hippocampus was present WD. Cerebellar observed
Abstract Background & Aims Ferroportin disease (FD) and hemochromatosis type 4 (HH4) are associated with variants in the ferroportin‐encoding gene SLC40A1 . Both phenotypes characterized by iron overload despite being caused distinct that either mediate reduced cellular export FD or resistance against hepcidin‐induced inactivation of ferroportin HH4. The aim this study was to assess if also confers hepcidin causes R178Q variant. Methods andA77D HH4‐variant C326Y were overexpressed...
Background and Aims High serum ferritin is frequent among patients with chronic liver disease commonly associated hepatic iron overload. Genetic causes of high include homozygosity for the p.Cys282Tyr variant in homeostatic regulator ( HFE ) rare variants non‐HFE genes. The aims present study were to describe landscape frequency mutations hemochromatosis genes determine whether patient selection by noninvasive quantification using MRI improves diagnostic yield next‐generation sequencing...
Background Anemia is present in up to two-thirds of patients undergoing colorectal surgery mainly caused by iron deficiency and inflammation. As anemia associated with increased risk perioperative death, diagnosis treatment preoperative according etiology have been recommended. Objective The aim the study was assess if association between survival determined severity alone or also etiology. Methods To determine prevalence etiology, hematological parameters, C-reactive protein, ferritin...
After HFE associated hemochromatosis mutations in SLC40A1, encoding the only known cellular iron exporter ferroportin, are commonest cause of genetic overload. Patients with mainly private SLC40A1 can present distinct phenotypes. Loss export function have been ferroportin disease phenotype whereas type 4 is gain mutations, where specific mutation render constitutively active and resistant against hepcidin mediated degradation.
Background Clinical presentation of Wilson disease (WD) is heterogeneous and includes hepatic neurologic manifestations. Genotype-phenotype correlations failed to identify factors associated with expression. WD known cause specific qualitative neuroradiologic changes hypo-intensities in basal ganglia. The aim the present study was test if patients predominantly or neurological phenotypic show quantitative differences when MRI results were analyzed by automated whole-brain segmentation procedure.