A5059040618- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Lysosomal Storage Disorders Research
- Diet and metabolism studies
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- Single-cell and spatial transcriptomics
- Adenosine and Purinergic Signaling
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Stress, Anesthesia, and Immune Response
- Endoplasmic Reticulum Stress and Disease
- Animal Genetics and Reproduction
- Genetic Syndromes and Imprinting
- Genetics and Neurodevelopmental Disorders
- Coenzyme Q10 studies and effects
- Alzheimer's disease research and treatments
- Retinoids in leukemia and cellular processes
University of California, San Francisco
2016-2025
Broad Center
2020-2021
University of Massachusetts Chan Medical School
2010-2016
Harvard University
2007
Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests involvement epigenetic pathways, mechanisms remains unclear. Two studies now show that altered paternal diet affects level mouse sperm. Chen et al. injected transfer RNA (tRNA) fragments from males had been kept on a high-fat into normal oocytes. The progeny displayed disorders and concomitant alteration genes pathways. Sharma observed...
Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive. Here we report that enzyme ten eleven translocation methylcytosine dioxygenase 2 (Tet2), which catalyzes production of 5-hydroxymethylcytosine (5hmC), rescues age-related decline in neurogenesis and enhances cognition mice. We detected a decrease Tet2 expression 5hmC levels aged hippocampus associated with...
During aging, microglia – the resident macrophages of brain exhibit altered phenotypes and contribute to age-related neuroinflammation. While numerous hallmarks have been elucidated, progression from homeostasis dysfunction during aging process remains unresolved. To bridge this gap in knowledge, we undertook complementary cellular molecular analyses mouse hippocampus across adult lifespan experimental model heterochronic parabiosis. Single-cell RNA-Seq pseudotime analysis revealed...
Mammalian X-linked gene expression is highly regulated as female cells contain two and male one X chromosome (X). To adjust the dosage between genders, mouse preimplantation embryos undergo an imprinted form of inactivation (iXCI) that requires both Rlim (also known Rnf12) long non-coding RNA Xist. Moreover, it thought from single active upregulated to correct for bi-allelic autosomal (A) expression. We have combined genetics with RNA-seq on investigate functions temporal regulation iXCI Our...
In utero therapy with recombinant enzyme or hematopoietic stem cells in MPS7 mice induces tolerance to missing and corrects brain microglia.
During aging, microglia – the resident macrophages of brain exhibit altered phenotypes and contribute to age-related neuroinflammation. While numerous hallmarks have been elucidated, progression from homeostasis dysfunction during aging process remains unresolved. To bridge this gap in knowledge, we undertook complementary cellular molecular analyses mouse hippocampus across adult lifespan experimental model heterochronic parabiosis. Single-cell RNA-Seq pseudotime analysis revealed...
DNA methylation has emerged as a critical modulator of neuronal plasticity and cognitive function. Notwithstanding, the role enzymes that demethylate remain to be fully explored. Here, we report loss ten-eleven translocation methylcytosine dioxygenase 2 (Tet2), which catalyzes oxidation 5-methylcytosine (5mC) 5-hydroxymethylcytosine (5hmC), in adult neurons enhances In mouse hippocampus, detected an enrichment Tet2 neurons. Viral-mediated overexpression RNA interference altered dendritic...
SUMMARY During aging, microglia – the resident macrophages of brain exhibit altered phenotypes and contribute to age-related neuroinflammation. While numerous hallmarks have been elucidated, progression from homeostasis dysfunction during aging process remains unresolved. To bridge this gap in knowledge, we undertook complementary cellular molecular analyses mouse hippocampus across adult lifespan experimental model heterochronic parabiosis. Single-cell RNA-Seq pseudotime analysis revealed...
Across species, spatial memory declines with age, possibly reflecting altered hippocampal and medial entorhinal cortex (MEC) function. However, the integrity of cellular network-level coding in aged MEC is unknown. Here, we leveraged
During aging, microglia – the resident macrophages of brain exhibit dystrophic phenotypes and contribute to age-related neuroinflammation. While numerous hallmarks dystrophy have been elucidated, progression from homeostasis dysfunction during aging process remains unresolved. To bridge this gap in knowledge, we undertook complementary cellular molecular analyses mouse hippocampus across adult lifespan experimental model heterochronic parabiosis. Single-cell RNA-Seq pseudotime analysis...
During aging, microglia – the resident macrophages of brain exhibit dystrophic phenotypes and contribute to age-related neuroinflammation. While numerous hallmarks dystrophy have been elucidated, progression from homeostasis dysfunction during aging process remains unresolved. To bridge this gap in knowledge, we undertook complementary cellular molecular analyses mouse hippocampus across adult lifespan experimental model heterochronic parabiosis. Single-cell RNA-Seq pseudotime analysis...
Dampening the Power of Brain—When Aging Meets Cognition Jeremy M Shea, PhD, PhD Department Anatomy, University California San Francisco Search for other works by this author on: Oxford Academic PubMed Google Scholar Saul A Villeda, FranciscoThe Eli and Edythe Broad Center Regeneration Medicine Stem Cell Research, Francisco, Address correspondence to: A. 513 Parnassus Avenue, Box 0452, CA 94143. E-mail: saul.villeda@ucsf.edu The Journals Gerontology: Series A, Volume 75, Issue 9, September...
Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether inheritance occurs in mammals, we carried out an expression profiling screen for genes mice that responded to paternal diet. Offspring males fed low protein diet exhibited elevated hepatic many involved lipid cholesterol biosynthesis, decreased levels esters, relative offspring control Epigenomic livers revealed numerous...