A5101399079- Epilepsy research and treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Mechanisms and Therapy
- Reproductive Biology and Fertility
- EEG and Brain-Computer Interfaces
- Sexual Differentiation and Disorders
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- COVID-19 Clinical Research Studies
- Agriculture, Soil, Plant Science
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Food Quality and Safety Studies
- Sperm and Testicular Function
- RNA modifications and cancer
- Microtubule and mitosis dynamics
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Vagus Nerve Stimulation Research
- Cerebrospinal fluid and hydrocephalus
- Protist diversity and phylogeny
- Cell death mechanisms and regulation
- Pharmacological Effects and Toxicity Studies
Beijing Sanbo Brain Hospital
2014-2024
Capital Medical University
2014-2024
Capital University
2024
German Centre for Cardiovascular Research
2022-2023
Chinese Institute for Brain Research
2014-2023
The First Affiliated Hospital, Sun Yat-sen University
2019-2022
Sun Yat-sen University
2019-2022
Institute of Microbiology
2022
Creative Commons
2022
Goethe University Frankfurt
2022
Breast cancer angiogenesis is key for metastasis and predicts a poor prognosis. Angiotensin-converting enzyme 2 (ACE2), as member of the renin-angiotensin system (RAS), was reported to restrain progression hepatocellular carcinoma (HCC) non-small cell lung (NSCLC) through inhibiting angiogenesis. However, relationship between ACE2 breast remains unclear.The prognosis relative gene selection were analysed using GEPIA, GEO, TCGA STRING databases. expression in tissue estimated by reverse...
Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, prognostic value whole family members was poorly done. Our study intends to demonstrate kinesin as biomarkers well therapeutic target cancer.Comprehensive bioinformatics analyses were done using data from TCGA, GEO, METABRIC, GTEx. LASSO regression select tumor-related members. Nomogram constructed predict overall survival (OS) cancer patients....
Abstract Long non‐coding RNAs (lncRNAs) take various effects in cancer mostly through sponging with microRNAs (miRNAs). lncRNA NR2F1‐AS1 is found to promote tumour progression hepatocellular carcinoma, endometrial and thyroid cancer. However, the role of breast angiogenesis remains unknown. In this study, we was positively related CD31 CD34 Pearson's correlation analysis, while transfection promoted human umbilical vascular endothelial cell (HUVEC) tube formation. cells, enhanced HUVEC...
To review the possible mechanisms proposed to explain etiology of 46, XX sex reversal by investigating clinical characteristics and their relationships with chromosomal karyotype SRY(sex-determining region Y)gene. Five untreated patients SRY-positive were referred for infertility. Clinical data collected, Karyotype analysis G-banding in lymphocytes Fluorescence situ hybridization (FISH) performed. Genomic DNA from peripheral blood using QIAamp Blood Kits was extracted. The three discrete...
Long non-coding RNAs (lncRNAs) can act as regulatory which, by altering the expression of target genes, impact on cellular phenotype and cardiovascular disease development. Endothelial lncRNAs their vascular functions are largely undefined. Deep RNA-Seq FANTOM5 CAGE analysis revealed lncRNA LINC00607 to be highly enriched in human endothelial cells. was induced response hypoxia, arteriosclerosis regression non-human primates, post-atherosclerotic cultured cells from patients also propranolol...
Objective Mutations in the type II collagen gene are associated with certain human disorders, collectively termed collagenopathies. They include Legg–Calvé–Perthes disease (LCPD) and avascular necrosis of femoral head (ANFH). These two diseases skeletal dysplasias, inherited an autosomal dominant fashion, characterized by groin pain, dislocation hip diminished joint mobility. Coxa vara elevation greater trochanter femur comprise typical phenotype LCPD, but do not occur ANFH. Lack synthesis...
Breast cancer (BC) is one of the most common female cancers, and its incidence has been increasing in recent years.Although treatments are continuously improving, prognosis patients advanced stage still unsatisfactory.Thus, an in-depth understanding molecular mechanisms necessary for curing breast cancer.KIF15 a tetrameric spindle motor which can regulate mitosis cellular process exert crucial functions several cancers.The purpose our research was to investigate KIF15 cancer.We tested...
Almost one-third of congenital cataracts are primarily autosomal dominant disorders, which also called cataract, resulting in blindness and clouding the lens. The purpose this study was to identify disease-causing mutation a Chinese family affected by bilateral, cataract. detection candidate gene linkage analysis microsatellite markers were performed for known genes. Molecular mapping cloning genes used all members screen potential genetic mutations confirmed single enzyme digestion. proband...
Ultrasound is commonly used in breast cancer screening but lacks quantification ability and diagnostic power due to its low specificity, which can lead overdiagnosis unnecessary biopsies. This study evaluated the efficacy clinical utility of adding shear-wave elastography (SWE) Breast Imaging Reporting Data System (BI-RADS) category 4 cancer.A machine learning-based model was constructed using data retrospectively collected from 3 independent cohorts with features selected lasso regression...
To identify the genetic defects and investigate possible mechanism of cataract genesis in a five-generation family with autosomal dominant congenital posterior polar cataracts. Clinical data were collected, lens phenotypes affected members this recorded by slit lamp photography. Genomic DNA was isolated from peripheral blood using QIAamp Blood Mini Kits. Twenty-three mutational hot spots associated cataracts screened PCR-based sequencing. Properties structural models wild-type mutant alpha-B...
BCR/ABL is a well-known activator of multiple signaling pathways. RalA, Ras downstream molecule and small GTPase, plays an important role in Bcr-Abl-induced leukemogenesis but the exact mechanism remains elusive. Here, we show that RalA GTPase activity commonly high chronic myelogenous leukemia (CML) cell lines patient samples. Overexpression results malignant transformation progression, induces resistance to imatinib (IM) BaF3 K562 lines. reduced survival led IM xenografted mouse model....
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) is wreaking havoc on public health systems worldwide. diagnosis of COVID-19 well defined, but efficacious treatment lacking. There a big gap in knowledge regarding patients receiving convalescent plasma transfusion (CPT), especially those also suffering from diabetes mellitus (DM). In this study, among 3059 admitted to Wuhan Huoshenshan Hospital China, we documented the characteristics...
An ovotesticular disorder of sex development (OT-DSD) was rarely found in human. The mechanism causing such condition is poorly understood. We hereby reported a 11-year-old child with OT-DSD and karyotype 46,XX/46,XY, single maternal double paternal genetic contribution to the patient. Fluorescence situ hybridization (FISH), blood grouping, HLA (human leukocyte antigen) haplotyping genome-wide scanning lymphocytes 398 short tandem repeat microsatellite markers were performed investigate...
Abstract To investigate the effect of hyperhomocysteinaemia (HHCy) on penile erectile function in a rat model, methionine-rich diet was used which function, reproductive system, and nitric oxide synthase were characterized. The intracavernous pressure, apomorphine experiments, measurement oxidative stress, hematoxylin eosin staining, immunohistochemistry analysis, reverse transcription-polymerase chain reactions endothelial activity utilized. Our results showed that erections middle-dose,...
<b><i>Background/Aims:</i></b> We have demonstrated previously that bipolar electrocoagulation on functional cortex (BCFC) is a safe and effective approach for epilepsy involving eloquent areas. Here, we report the results of BCFC with lesionectomy patients epileptogenic foci partially overlapping <b><i>Methods:</i></b> Forty who had been treated were retrospectively reviewed regard to seizure outcome neurological deficits. Ten similar received...
Metastasis is a major factor weakening the long-term survival of breast cancer patients. Increasing evidence revealed that long non-coding RNAs (lncRNAs) were involved in occurrence and development cancer. In this study, we aimed to investigate role LGALS8-AS1 metastatic progression cells its potential mechanisms.The lncRNA was highly expressed associated with poor survival. functioned as an oncogenic promoted metastasis both vitro vivo. It upregulated SOX12 via competing endogenous RNA...
Background To determine whether the embryo developmental stage affects biochemical or clinical pregnancy loss in young women undergoing frozen-thawed transfer (FET) and to investigate underlying mechanism. Methods This was a retrospective study including total of 18,34 β-HCG (human chorionic gonadotropin)-positive FET cycles. According morphological appearance (MA) transferred blastocysts, cycles with blastocysts were divided into two groups: Group A: morphologically good (MG) only, B: at...