A5042300078- Angiogenesis and VEGF in Cancer
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
First Affiliated Hospital of Bengbu Medical College
2021-2024
Bengbu Medical College
2022
Abstract Type IIA topoisomerase (TOP2A) is significantly associated with malignant tumor development, invasion, treatment and its prognosis, has been shown to be a therapeutic target against cancer. In contrast, the role of TOP2A in immunotherapy non-small cell lung cancer as well Vasculogenic mimicry (VM) formation potential mechanisms are unclear. The aim this study was investigate proliferation, skeleton regulation, motility VM production by using bioinformatics tools molecular biology...
Abstract DNA topoisomerase II alpha (TOP2A) expression, gene alterations, and enzyme activity have been studied in various malignant tumors. Abnormal elevation of TOP2A expression is considered to be related the development non-small cell lung cancer (NSCLC). However, its association with tumor metastasis mode action remains unclear. Bioinformatics, real-time quantitative PCR, immunohistochemistry immunoblotting were used detect NSCLC tissues cells. Cell migration invasion assays as well...
Abstract Background PD-L1 overexpression is commonly observed in various malignancies and strongly correlated with poor prognoses for cancer patients. Moreover, has been shown to play a significant role promoting angiogenesis epithelial-mesenchymal transition (EMT) processes across different types. Methods The relationship between vasculogenic mimicry as well was explored by bioinformatics approach immunohistochemistry. functions of regulating the expression ZEB1 EMT process were assessed...
Tumor infiltration and metastasis are the leading causes of death for patients with tumors. Angiogenesis is a prerequisite tumor growth metastasis. Angiogenic factor G patch FHA domains 1 (AGGF1) an angiogenic factor, whereas ubiquitin-conjugating enzyme E2C (UBE2C) functions in protein ubiquitination. Microvessel density (MVD) most common indicator microvessels, vasculogenic mimicry (VM) facilitates blood supply to This study explored UBE2C AGGF1 expression non-small cell lung cancer...
Vasculogenic mimicry (VM) is a recently identified pattern of blood supply to tumor tissue. It has long been considered functional element in the metastasis and prognosis malignant tumors. Both Rho GTPase-activating protein 25 (ARHGAP25) Ras homolog family member A (RhoA) are effective predictors metastasis. In this study, we examined expression levels ARHGAP25 RhoA structure VM non-small cell lung cancer (NSCLC). At same time, used cytology-related experiments explore effect on migration...
Abstract Background: Lung adenocarcinoma (LUAD) is a common histologic subtype of lung cancer with high morbidity and mortality. Tumor endothelial cells (TEC) are associated tumor progression metastasis. In this study, we explored the effect TEC on prognosis immunotherapy LUAD based single-cell transcriptome Bulk transcriptome. To help patients obtain accurate clinical treatment strategies. Methods: We identified marker genes by in study. data were downloaded from The Cancer Genome...
Abstract Background: Type IIA topoisomerase (TOP2A) is significantly associated with malignant tumor development, invasion, treatment and its prognosis, has been shown to be a therapeutic target against cancer. In contrast, the role of TOP2A in immunotherapy non-small cell lung cancer as well VM formation potential mechanisms are unclear. Methods: Based on 82 co-expressed genes screened, consensus molecular typing was performed by NMF algorithm, effect further evaluated two groups patients...