A5040505217- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Hip and Femur Fractures
- Peroxisome Proliferator-Activated Receptors
- Orthopaedic implants and arthroplasty
- Birth, Development, and Health
- Bone fractures and treatments
- Gout, Hyperuricemia, Uric Acid
- Inflammatory mediators and NSAID effects
- Gestational Diabetes Research and Management
- MicroRNA in disease regulation
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
Fudan University
2009-2024
Huadong Hospital
2004-2022
Anyang Hospital of Traditional Chinese Medicine
2008-2013
Knee osteoarthritis (KOA) is a degenerative knee disease commonly found in the ageing population. DNA methylation works with histone acetylation to participate aging. Alterations of may involve joint chondrocyte degeneration KOA. The aim this study detect changes chondrocytes rats rat KOA model was established Hulth method (n = 10), while receiving sham operation served as control 10). At 16 weeks after modeling, tissue collected from half each group for Micro-CT scanning, Haematoxylin&...
To investigate the effects of Qi-Fang-Xi-Bi-Granules (QFXBGs) on cartilage morphology and methylation C/ebpα (CCAAT/enhancer binding proteinα) at promoter region.Knee osteoarthritis (KOA) modeling was performed in rats accordance with Hulth's method, control group received sham operation. Eight weeks after KOA modeling, were further divided into 6 groups. Each given appropriate drug. After 8 weeks, half used for Micro-CT scan, HE staining, ABH/OG immunohistochemistry, TUNNEL staining knee...
The American Heart Association has updated its definition of cardiovascular health (CVH) with a new framework known as Life's Essential 8 (LE8). Although gestational CVH assessment been recommended, significance based on LE8 for birth outcomes is unknown. We thus evaluated the status in 3036 pregnant women Shanghai Maternal-Child Pairs Cohort and population China Maternal Nutrition Health Sciences Survey, also examined association between child outcomes. found that only small proportion...
Objective To observe the effects of trimetazidine (TMZ) on cardiac function and neurohormonal heart failure model in rats.Methods Partially banding abdominal aortic artery to achieve congestive rats model.Interventricular septum thickness(IVST),left ventricular posterior wall thickness(LVPWT),left end-diastolic diameter(LVEDD),left end-systolic diameter (LVESD),left ejection fraction(LVEF) shortening fraction(FS) were measured by echocardiogram,Pathological changes myocardial cells was...