A5041358935- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Erythropoietin and Anemia Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Parathyroid Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Sarcoidosis and Beryllium Toxicity Research
- Atomic and Subatomic Physics Research
- Tissue Engineering and Regenerative Medicine
- Heart Rate Variability and Autonomic Control
- Hemoglobin structure and function
- Spaceflight effects on biology
- Cardiovascular Function and Risk Factors
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Adipose Tissue and Metabolism
- Erythrocyte Function and Pathophysiology
- Physiological and biochemical adaptations
- Mesenchymal stem cell research
The University of Texas Southwestern Medical Center
2016-2025
American Thoracic Society
2023
Southwestern Medical Center
2000-2020
University of Birmingham
2020
Pulmonary and Critical Care Associates
2010
Max Planck Institute for Developmental Biology
2007
University of California, Los Angeles
2007
University of Bern
2007
University of Bonn
2007
University of California, Irvine
2007
Keywords: morphometry; stereology; unbiased sampling; reference lung volume; cell surface area; size; number; in vivo imaging
Advancements in methods, technology, and our understanding of the pathobiology lung injury have created need to update definition experimental acute (ALI). We queried 50 participants with expertise ALI respiratory distress syndrome using a Delphi method composed series electronic surveys virtual workshop. propose that presents as “multidimensional entity” characterized by four “domains” reflect key pathophysiologic features underlying biology human syndrome. These domains are 1) histological...
Diffusing capacity of the lung for nitric oxide ( D LNO ), otherwise known as transfer factor, was first measured in 1983. This document standardises technique and application single-breath . panel agrees that 1) pulmonary function systems should allow mixing measurement both (NO) carbon monoxide (CO) gases directly from an inspiratory reservoir just before use, with expired concentrations alveolar “collection” or continuously sampled via rapid gas analysers; 2) breath-hold time be 10 s...
α-Klotho exerts pleiotropic biological actions. Heterozygous haplo-insufficient mice (kl/+) appear normal at baseline except for age-related changes in the lung, suggesting heightened pulmonary susceptibility to deficiency. We used vivo and vitro models test whether protects lung epithelia against injury. Normally, is not expressed but circulating levels are reduced -40% kl/+ undetectable homozygous α-Klotho-deficient (kl/kl). show distal air space enlargement a given airway pressure, with...
Alveolar microvascular function is moderately impaired in type 1 diabetes, as manifested by restriction of lung volume and diffusing capacity (DL(CO)). We examined whether similar impairment develops 2 diabetes defined the physiologic sources well relationships to glycemia systemic microangiopathy.A cross-sectional study was conducted at a university-affiliated treatment center outpatient clinic, involving 69 nonsmoking diabetic patients without overt cardiopulmonary disease. Lung volume,...
Abstract Purpose: To investigate the utility of ultra‐short echo time (UTE) sequence as pulmonary MRI to detect non‐uniform disruption lung architecture that is typical emphysema. Materials and Methods: lungs was conducted with a three‐dimensional UTE in transgenic mice severe emphysema their wild‐type littermates 3 Tesla clinical MR system. Measurements signal intensity (SI) transverse relaxation (T2*) parenchyma were performed various times (TEs) ranging from 100 μs 2 ms. Results: Much...
Pulmonary dysfunction develops in type 2 diabetes mellitus (T2DM) direct correlation with glycemia and is exacerbated by obesity; however, the associated structural derangement has not been quantified. We studied lungs from obese diabetic (fa/fa) male Zucker fatty (ZDF) rats at 4, 12, 36 wk of age, before after onset T2DM, compared lean nondiabetic (+/+) rats. Surfactant proteins A C (SP-A SP-C) immunoexpression lung tissue was quantified ages 14 18 wk, T2DM. In fa/fa animals, volume normal...
Lung diffusing capacity for nitric oxide (DLNO) is used to measure alveolar membrane conductance (DMNO), but disagreement remains as whether DMNO=DLNO, and blood (thetaNO)=infinity. Our previous in vitro vivo studies suggested that thetaNO<infinity. We now show a oxygenator model perfused with whole addition of cell-free bovine hemoglobin (Hb) glutamer-200 solution increased the circuit (D) NO (DNO) by 39%, D carbon monoxide (DCO) 24%, ratio DNO DCO 12% (all P<0.001). In three anesthetized...