A5025062975- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Livestock Management and Performance Improvement
- Reproductive Biology and Fertility
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Tuberculosis Research and Epidemiology
- Effects of Environmental Stressors on Livestock
- Reproductive tract infections research
- Organ Transplantation Techniques and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Protein Degradation and Inhibitors
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Animal Nutrition and Physiology
- Identification and Quantification in Food
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Rangeland Management and Livestock Ecology
- Molecular Biology Techniques and Applications
University of Wisconsin–Madison
2024-2025
Wisconsin Division of Public Health
2025
Sindh Agriculture University
2013-2018
Justus-Liebig-Universität Gießen
2011
Background: Approximately 15-20% of head and neck cancer squamous cell carcinoma (HNSCC) patients respond favorably to immune checkpoint blockade (ICB). Previous single-cell RNA-Seq (scRNA-Seq) studies identified features, including macrophage subset ratios T-cell subtypes, in HNSCC ICB response. However, the spatial features HNSCC-infiltrated cells response treatment need be better characterized. Methods: Here, we perform a systematic evaluation interactions between types within tumor...
Abstract Hormone receptor (HR)-positive, HER2-positive breast cancers often develop resistance to endocrine and anti-HER2 therapies due the heterogeneous expression of estrogen (ER) HER2 crosstalk these growth-promoting pathways. However, how agents activate ER other pathways remains unknown. Single-cell RNA sequencing BT474 cancer cells identified Bromodomain Containing Protein 8 (BRD8), an acetyl-lysine reader protein in histone acetylase EP400 complex, as a pivotal mediator response...
Neutrophils accumulate early in tissue injury. However, the cellular and functional heterogeneity of neutrophils during homeostasis response to damage remains unclear. In this study, we use larval zebrafish understand neutrophil responses thermal Single-cell transcriptional mapping myeloid cells a 3-d time course burn control larvae revealed distinct subsets their cell-cell interactions with macrophages across conditions. The trajectory formed by three resembles human maturation, varying...
A study was designed to evaluate the effect of Prostaglandins(PG)F2α (Cloprostenol) and oxytocin on postpartum anestrus uterine involution Kundhi buffaloes. Total 30 multiparous buffaloes similar parity from potential farm in vicinity Tandojam city were selected. These animals divided into three groups i.e. I, II III having 10 numbers each group. The group I treated with 2ml PGF2α (0.150 mg Cloprostenol) intramuscularly , given (100 I.U.) as control administered normal saline immediately...
The aim of this study was to evaluate the incidence various reproductive disorders and effect calving seasons on postpartum estrus, uterine involution service period their relation fertility Kundhi buffaloes. For purpose, 1000 advanced pregnant pluriparous buffaloes from 16 villages in rural peri-urban areas district Hyderabad Sindh Pakistan were selected. These animals divided into two main groups, group I had normal unassisted parturition (n=743) II with certain peri post parturient...
<h3>Background</h3> Like many cancer types, only ~20% of head and neck (HNC) patients respond favorably to immune checkpoint blockade (ICB) therapy. Previous single-cell RNA-Seq (scRNA-Seq) studies identified features, including macrophage subset ratios T-cell subtypes,<sup>1–3</sup> in HNC ICB outcomes. However, the spatial features HNC-infiltrated cells response treatment need be better characterized. Here we perform a systematic evaluation cell interactions between types within tumor...
Background: miRNA's are small RNA molecules that involved in post-transcription mRNA regulation through degradation or translational inhibition, via natural cellular processes. A single miRNA families of may target many different species resulting the sections even whole functional pathways. To explore function signaling and impact their targets acute rejection, we investigated expression various using microfluidic QPCR matched microarrays. Methods: The kidney transplant tissue biopsy...