A5066280570- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Soft tissue tumor case studies
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vascular Malformations and Hemangiomas
- Pancreatitis Pathology and Treatment
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders
- Gastrointestinal Tumor Research and Treatment
- Vasculitis and related conditions
- Autoimmune Bullous Skin Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Urticaria and Related Conditions
- Heart Rate Variability and Autonomic Control
- Immune Cell Function and Interaction
- Inflammatory Myopathies and Dermatomyositis
- Biomedical Research and Pathophysiology
- Psoriasis: Treatment and Pathogenesis
- Otitis Media and Relapsing Polychondritis
- Phagocytosis and Immune Regulation
University of Tokyo Hospital
2022
Sapporo Medical University
2009-2019
IgG4-related disease (IgG4-RD) is a novel entity that includes Mikulicz's disease, autoimmune pancreatitis (AIP), and many other conditions. It characterized by elevated serum IgG4 levels abundant IgG4-bearing plasmacyte infiltration of involved organs. We postulated high would comprise useful diagnostic tool, but little information available about in conditions than IgG4-RD, including rheumatic diseases. Several reports have described cutoff values for when diagnosing these studies mostly...
Objective. Immunoglobulin (Ig)G4-related disease (IgG4-RD) is a new entity that has only been identified this century. Clinical information thus lacking. We established the Sapporo Medical University and Related Institutes Database for Investigation Best Treatments of IgG4-related Disease (SMART) to clarify clinical features IgG4-RD provide useful clinicians. Methods. Participants comprised 122 patients with dacryoadenitis and/or sialadenitis (IgG4-DS), representing lacrimal salivary lesions...
Immunoglobulin G4 (IgG4)–related aortitis/periaortitis and periarteritis are vascular manifestations of IgG4-related disease. In this disease, the affected aneurysmal lesion has been suspected to be at risk rupture. study, we aimed clarify clinical course after corticosteroid therapy in periarteritis. We retrospectively evaluated features, including laboratory data, imaging findings therapy, 40 patients diagnosed with on basis periaortic/periarterial radiological findings, satisfaction...
Mikulicz's disease (MD) is characterized by symmetrical and persistent enlargement of the lacrimal salivary glands. Recently it has been categorized as an 'Ig (immunoglobulin) G4-related disease.' It presents with elevated serum levels IgG4 abundant infiltration IgG4-bearing plasmacytes in involved organs. Allergic symptoms are often observed patients IgG4-related disease. On other hand, allergic diseases complicated Churg-Strauss syndrome (CSS). Here we focused on CSS analyzed relation its...
IgG4-related disease (IgG4-RD) is a newly recognized systemic chronic fibroinflammatory disease. However, the pathogenesis of IgG4-RD remains unknown. To determine pathophysiologic features IgG4-RD, we examined T follicular helper (Tfh) cells in lesions and blood from patients with IgG4-RD. Patients dacryoadenitis sialadenitis (IgG4-DS) showed increased infiltration Tfh highly expressing programmed death 1 ICOS submandibular glands. IgG4-DS glands had higher expression B cell lymphoma 6...
Abstract Glucocorticoids (GC) are effective for treating IgG4-related disease (IgG4-RD); however, relapse is often observed. We conducted a retrospective multicentre study to investigate risk factors in GC regimens associated with relapses of IgG4-RD. Data on 166 patients definitive IgG4-RD diagnosis were collected from 12 institutions. Comprehensive surveillance clinical backgrounds and as well multivariate analysis treatment responses was performed. To determine the initial maximal dose,...
IgG4-related disease (IgG4-RD) is a chronic fibroinflammatory characterized by elevation of serum IgG4 level as well infiltration IgG4+ plasma cells in various affected organs. The etiology IgG4-RD still not fully understood. Since more prevalent the elderly, aging itself considered to be an important risk factor IgG4-RD. However, relationship between pathogenesis and immunosenescence remains unknown. To clarify age-related features underlying IgG4-RD, we focused on T follicular regulatory...
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease, and disease activity associated with serum IFN-α level. Plasmacytoid dendritic cells (pDCs) sense microbial as well self-nucleic acids by TLRs 7 9 produce large amount of IFN-α. Here, we show that heat shock protein 90 (Hsp90) associates delivers TLR7/9 from the ER to early endosomes for ligand recognition. Inhibition Hsp90 various approaches including use inhibitor, geldanamycin derivative, suppressed association...
Journal Article Tofacitinib can decrease anti-DNA antibody titers in inactive systemic lupus erythematosus complicated by rheumatoid arthritis Get access Motohisa Yamamoto, Yamamoto Division of Rheumatology and Clinical Immunology, Sapporo Medical University School Medicine, Sapporo, Hokkaido, Japan Correspondence to: South 1 West 16, Chuo-ku, Hokkaido 060-8543, Japan. Tel: + 81-11-611-2111. Fax: 81-11-611-2282. E-mail: mocha@cocoa.plala.or.jp Search for other works this author on: Oxford...
T follicular helper (Tfh) cells drive humoral immunity by facilitating B cell responses at the initial and recall phases. Recent studies have indicated possible involvement of Tfh in process chronic inflammation. However, functional role persistent immune settings remains unclear. Here, we report that CD4 + CD8 (double-positive, DP; CD3 CXCR5 hi PD-1 ) cells, a subset germinal-center-type were abundantly present fibroinflammatory lesions patients with immunoglobulin G4-related disease...
Journal Article CCAAT/enhancer binding protein α (C/EBPα)+ M2 macrophages contribute to fibrosis in IgG4-related disease? Get access Motohisa Yamamoto, Yamamoto Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School Medicine, Sapporo, Japan Correspondence to: South 1- West 16, Chuo-ku, Hokkaido 0608543, Japan. Tel: + 81-11-611-2111. Fax: 81-11-611-2282. E-mail: mocha@cocoa.plala.or.jp Search for other works by this author on: Oxford Academic...
Objectives: Patients with immunoglobulin-G4 related disease (IgG4-RD) diagnosed according to the comprehensive diagnostic criteria (CDC) show varied therapeutic responses and prognoses. We assumed that there are clinical stages in IgG4-RD have verified it using serum cytokine levels groups classified by lesion distribution. Methods: Definite IgG4-related dacryoadenitis sialadenitis (IgG4-DS) cases were divided CDC for into 11 focal type 30 systemic type. The of interleukin (IL)-4, IL-5,...
<h3>Background</h3> IgG4-related disease (IgG4-RD) is considered a systemic, chronic and inflammatory disorder that characterized by elevated levels of serum IgG4 abundant infiltration IgG4-bearing plasmacytes storiform fibrosis in the involved organs. It includes autoimmune pancreatitis type I, Mikulicz's (MD; dacryoadenitis sialadenitis), part tubulointerstitial nephritis (IgG4-related nephritis). necessary to manage this as soon possible prevent permanent organ damages. Glucocorticoid...
Objectives: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is often complicated by allergic disorders. This study was conducted to investigate the mechanism of type 2 helper T-inflammation (Th2-inflammation) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS). Methods: We separated analyzed proportion growth stimulation expressed gene (ST2)+ memory Th2 cells among peripheral blood mononuclear flow cytometry cases with IgG4-DS healthy individuals. Finally, we identified role ST2+...
A 23-year-old Japanese woman was diagnosed with lupus nephritis on May 2007. The patient prescribed 30 mg/day of prednisolone, but developed a pulmonary abscess and admitted to Sapporo Medical University Hospital in March 2008. Antibiotics improved the symptoms. We trimethoprim-sulfamethoxazole as prophylaxis for pneumocystis pneumonia; however, fever thrombocytopenia hyperferritinemia after week this prophylaxis. considered that she developing hemophagocytic syndrome, administered...
Mikulicz's disease (MD) has been considered part of primary Sjögren's syndrome (SS) since Morgan's report in 1953. However, MD shows a unique condition involving persistent swelling the lachrymal and salivary glands characterized by good responsiveness to glucocorticoids, leading recovery gland function. Recently, it revealed that patients show elevated serum immunoglobulin G4 (IgG4) concentrations prominent infiltration IgG4-positive plasma cells. The complications include autoimmune...
The newly established concepts of Mikulicz's disease and Kuttner's tumor (chronic sialadenitis) are discussed. has been included within the diagnosis primary Sjogren's syndrome, but it represents a unique condition involving persistent enlargement lacrimal salivary glands. Recently, elevated IgG4 concentration in serum prominent infiltration by plasmacytes expressing glands was demonstrated disease. differs from may be systemic IgG4-related plasmacytic is chronic sclerosing sialadenitis that...